Do Any Posters See Any Hope For Follica?

[Xaser94]

This clown hasn't figured out that they were "done with phase 2" five years ago.

The main take away was the update from the site. It's always interesting when people belittle others online, especially when we are all fighting the same battle.

 

[hairblues]

This clown .

That was uncalled for.

 

[hairblues]

@Xaser94 is one of the very few posters who finds and then posts really relevant information for all of us.

Im sure many people here appreciate it.

 

[That Guy]

This clown hasn't figured out that they were "done with phase 2" five years ago.

and you still haven't figured out how to stop being a piece of sh*t.

 

[coolio]

Just to bring this up again - The achievement of "creating new follicles" is not necessarily the end of our problem yet. Simple wounding alone can already do that, and almost all of the follicles it creates are vellus-sized or worse. A few years back they even used the term "proto-follicle structures".

The quality of the follicles that Follica produces is the big issue. We need terminals. We need them densely-packed. We need them consistently.

 

[NewUser]

View attachment 46384

According to pure tech's website they are done with phase 2, and will be starting phase 3. The update on their pipeline is def positive. I also think Follica may be the first new androgenetic alopeica treatment to be starting phase 3, or at least in a long time. The closest thing after this to starting phase 3 is Samumed. So I see a lot of hope for it.

Thanks Xaser94. So they think they have something good enough for a phase 3 pivotal. According to the wiki on Phases of Clinical study, the success rate for Phase II trials that proceed to Phase III, as of 2010, is 18%. Success rate for Phase III studies, however, is 50%

 

[luiza]

Just to bring this up again - The achievement of "creating new follicles" is not necessarily the end of our problem yet. Simple wounding alone can already do that, and almost all of the follicles it creates are vellus-sized or worse. A few years back they even used the term "proto-follicle structures".

The quality of the follicles that Follica produces is the big issue. We need terminals. We need them densely-packed. We need them consistently.

According to Gail Naughton (from Histogen), they can transform any vellus hair in terminal. They said that in one of the interviews.
Also, many other companies are trying to do the same. I think that as long as you have vellus hair you're still good and will benefit from the upcoming treatments.

So I guess maybe Follica will be good in combination with other treatments.

 

[coolio]

Histogen can say that but I wanna see proof.

Follica's hairs would be natural in the strict sense but they may still be different enough that Histogen's treatment doesn't work on them in the same way or success rate.

Bottom line, we aren't sure of anything until we see live humans with big obvious batches of new hair on their heads. NOTHING ELSE totally proves it. NOTHING.

 

[KO1]

Just to bring this up again - The achievement of "creating new follicles" is not necessarily the end of our problem yet. Simple wounding alone can already do that, and almost all of the follicles it creates are vellus-sized or worse. A few years back they even used the term "proto-follicle structures".

The quality of the follicles that Follica produces is the big issue. We need terminals. We need them densely-packed. We need them consistently.

Indeed, they haven't shown that these "neogenic-like follicles" are going to turn into dense terminal hair yet. Kligman already demonstrated new vellus hair in the 60s, so its nbd if Follica grows a few.

 

[luiza]

Histogen can say that but I wanna see proof.

Follica's hairs would be natural in the strict sense but they may still be different enough that Histogen's treatment doesn't work on them in the same way or success rate.

Bottom line, we aren't sure of anything until we see live humans with big obvious batches of new hair on their heads. NOTHING ELSE totally proves it. NOTHING.

In my opinion Histogen pics were pretty impressive, despite the slight difference in lighting and angle between the "before and after".
Their data showed not only regrowth but an increase in overall thickness.
Remember those results were after 3 months only and from only one round of injections at a very safe dosage.

I think that if it works for "normal" vellus hair it might work for Follica's vellus hair too since that's nothing but your natural hair being forced to grow.

And we will also have Replicel that will do the same thing (make vellus hairs go terminal), with a different mechanism.

Yeah, it's all speculation but in my opinion we have good chances a combination of these (or even one of these treatments alone) will work extremely well.

 

[Baldybald1]

And will be costly to combine all that treatments, but I think the at home treatment from follica will bring vellus to terminal.

In my opinion Histogen pics were pretty impressive, despite the slight difference in lighting and angle between the "before and after".
Their data showed not only regrowth but an increase in overall thickness.
Remember those results were after 3 months only and from only one round of injections at a very safe dosage.

I think that if it works for "normal" vellus hair it might work for Follica's vellus hair too since that's nothing but your natural hair being forced to grow.

And we will also have Replicel that will do the same thing (make vellus hairs go terminal), with a different mechanism.

Yeah, it's all speculation but in my opinion we have good chances a combination of these (or even one of these treatments alone) will work extremely well.

a

In my opinion Histogen pics were pretty impressive, despite the slight difference in lighting and angle between the "before and after".
Their data showed not only regrowth but an increase in overall thickness.
Remember those results were after 3 months only and from only one round of injections at a very safe dosage.

I think that if it works for "normal" vellus hair it might work for Follica's vellus hair too since that's nothing but your natural hair being forced to grow.

And we will also have Replicel that will do the same thing (make vellus hairs go terminal), with a different mechanism.

Yeah, it's all speculation but in my opinion we have good chances a combination of these (or even one of these treatments alone) will work extremely well.

 

[Swoop]

If his lotion is Minoxidil only I'll be pretty disappointed

But this isn't about you or me. This is about a company who's primary objective is to gain profit.

Doing minoxidil or PGF2a just a "tad" better can be enough to convince hordes of emotional hair loss sufferers .

 

[coolio]

So what if Follica really is using minoxidil? Big deal.

Do they owe us a grander method than that, just on principle? Right now we have NOTHING that regrows ANYTHING. If they come up with a way to provoke more hair regrowth than we knew about previously then it's all progress, baby steps or not.

I don't think this is a choice between either gettting a product now or having Follica continue the R&D. If it does some good then they will probably try to keep working on it. And others may start chasing the ideas too.

 

[luiza]

I wish there was something else besides Minoxidil because I've been using it for 10 years and have noticed it gives me a lot of side effects.

My blood pressure has never been so low, which gives me constant fatigue and even dizziness sometimes. I blame Minoxidil since almost everyone in my family has high blood pressure and my medical exams didn't show anything abnormal. I also get a lot of heart palpitations. and knowing it destroys collagen only makes me more worried for having used it for so long.
I don't think this stuff is 100% safe in the long term and it's time for someone to come out with something else.

I wanna stop using Minoxidil but deep down I believe it's what has been keeping my hair loss "stable" (even though it's not that stable anymore). I still lose a lot of hair but it has definitely slowed it down.

Of course it would be already great if Cots could make it 100 times more effective but that (in theory) means the side effects would become 100 times worse as well.

The ones who don't get any side effects will think I'm just overreacting though...

 

[KO1]

So what if Follica really is using minoxidil? Big deal.

Do they owe us a grander method than that, just on principle? Right now we have NOTHING that regrows ANYTHING. If they come up with a way to provoke more hair regrowth than we knew about previously then it's all progress, baby steps or not.

I don't think this is a choice between either gettting a product now or having Follica continue the R&D. If it does some good then they will probably try to keep working on it. And others may start chasing the ideas too.

Exactly. I hope they make a "yuuge" profit and use funds to drive research so we can grow big, beautiful hair. That, and others can also refine the idea further once they see this method as viable.

 

[coolio]

We (suspect) that Follica will use minoxidil to help provoke the creation of more hair. We don't know that this new hair will require permanent minoxidil just to maintain it.

In fact I think it's quite possible that whatever hair they create will not be especially minoxidil-dependent once it is formed.