Do Any Posters See Any Hope For Follica?

[Swoop]

Remember that Follica is around since 2005, that's almost 12 years now. They have initiated several clinical trials which were based on the wounding aspect alone. Then they also did wounding + lithium gluconate 8% and it failed.

Follica’s three clinical studies of patients with androgenetic alopecia demonstrated hair follicle neogenesis via biopsy following skin disruption and/or hair growth through target area hair count. One of these studies demonstrated that skin disruption alone was safe and generates new follicles as well as new hair, but did not achieve its primary endpoint as the chosen investigational compound (lithium gluconate 8 percent gel) did not further enhance the effect

The conclusion to this is very simple. Wounding on itself simply wasn't good enough. If it was good enough, any company would proceed to launch it to the market as soon as possible.

This industry is logical and straightforward. If something holds good promise they flaunt with the results and rapidly try to release the drug/treatment to the market. They will make extreme noise. I see it all the time.

Can Follica create new hair follicles? Well there is no hard evidence for that at the moment. Remember that we need proper healthy hair follicles on our scalp, not on our body, and we don't need shitty vellus hair either.

Well they actually DO have evidence by the way, but they didn't publish it...

Apparently the document is from 2008 which can deliver the proof of the creation of new hair follicles. Well it's almost 2017, 9 years later. Come on..

And they absolutely seem to love to refer to that third party published research study from Mumbai;

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746236/

Which used minoxidil + microneedling.

"Yo guys we can supposedly create new hair follicles, we ain't publishing that evidence though, let's just constantly refer to this Mumbai study"

LOL. I literally don't know if I need to cry or laugh.

Ohw yeah and wasn't Follica supposed to initiate a registration study already?

"Follica plans to initiate a registration study in the second half of 2016, with data read-out in 2017."

Typical .

Follica will simply be probably relying on the "success" of minoxidil.

 

[tomJ]

Guys I believe they will rely on wounding and minoxidil to keep the new follicles alive. Some of you are confusing cots wounding with dermarolling. Cots wounding is much more invasive. Dermarollinh really just helps topical penetrate the scalp. Their is quite the difference.

 

[thegoodthebaldtheugly]

A dumb question in all possibility, but would we have to get rid of all our existing hair for this? What about folks who have long-ish hair?

 

[luiza]

A dumb question in all possibility, but would we have to get rid of all our existing hair for this? What about folks who have long-ish hair?

No one knows yet but I don't think so.. I think it would only be worth to shave our scalps if they promised us we would get a full head of hair with the treatment.
Cots must know not many people would be willing to do that (especially women) if he can't give them great results.

 

[thegoodthebaldtheugly]

No one knows yet but I don't think so.. I think it would only be worth to shave our scalps if they promised us we would get a full head of hair with the treatment.
Cots must know not many people would be willing to do that (especially women) if he can't give them great results.

Interesting. I'm unsure as to how they're disrupt the scalp without getting rid of the existing hair, but you do make a valid point.

 

[KO1]

The follicles lie deeper than where they're (likely) planning to disrupt the scalp.

 

[thegoodthebaldtheugly]

The follicles lie deeper than where they're (likely) planning to disrupt the scalp.

Implying..?

 

[resu]

I don't believe anything that will create new follicles will come out anytime soon just the same established methods but with less side effects. I only have hope for Breezula and the Brotzu lotion as the wildcard for thickening and maintaining.

Seti should be interesting too but not as a single treatment and I believe it should really kill the damn itch.

 

[thegoodthebaldtheugly]

I don't believe anything that will create new follicles will come out anytime soon just the same established methods but with less side effects. I only have hope for Breezula and the Brotzu lotion as the wildcard for thickening and maintaining.

Seti should be interesting too but not as a single treatment and I believe it should really kill the damn itch.

Didn't the Breezula trials show no improvement at all?

 

[Gone]

No they showed amazing (2 fold) hair diameter increases, a higher number of test subjects with both hair growth and decline than minoxidil, and less consistent maintenance than minoxidil.

The diameter increase and CB vs. minoxidil were 2 different studies though.

 

[thegoodthebaldtheugly]

Wait, what? Two different studies -- one showed a 2 fold diameter increase, and other showed decline and less consistent maintenance than minoxidil?

 

[Gone]

The minoxidil comparison also showed a greater number of patients with significant regrowth. Let me show you, hold on

 

[Gone]

 

[Gone]

I guess I really should pay more attention to the thread titles, since this is supposed to be about follica. Maybe make another thread if you want to talk about this more

It would be f*****g awesome if follica threw something like fgf9 in I don't know, ain't too optimistic I guess.

 

[hairblues]

I guess I really should pay more attention to the thread titles, since this is supposed to be about follica. Maybe make another thread if you want to talk about this more

It would be f*****g awesome if follica threw something like fgf9 in I don't know, ain't too optimistic I guess.

i don know anything about this one--if its a new possible treatment maybe make a new thread is good?

Do yu have more information on it?

 

[Gone]

The stuff I was saying earlier was about CB/Breezula, which is pretty well covered and has some info on the pipeline if you're interested. Those two images are pretty much the most important information we have regarding its efficacy.

I think it's relevant to post info on fgf9 here, so here's a link. Very helpful for maximising hair neogenesis and also brought to attention by George Cotsarelis.

https://www.ncbi.nlm.nih.gov/m/pubmed/23727932/

 

[resu]

Didn't the Breezula trials show no improvement at all?

No it showed an higher response rate than minoxidil but smaller when it comes to hair count because it's an anti-androgen, minoxidil if you respond you see results in the first 3 to 6 months.

 

[NewUser]

Remember that Follica is around since 2005, that's almost 12 years now. They have initiated several clinical trials which were based on the wounding aspect alone. Then they also did wounding + lithium gluconate 8% and it failed.

Well, then, they should quit while they are ahead, yes? Why pour more money into a losing venture with little to no hope of success?

The conclusion to this is very simple. Wounding on itself simply wasn't good enough. If it was good enough, any company would proceed to launch it to the market as soon as possible.

okay, then, case closed "gavel smack". The court of swoop is adjourned.

PS: I think Follica has something, and after 12 years of research including garnering a spotlight in Nature mag and bothering to secure patents , it's likely to be more than micro-needling with minoxidil.

 

[Baldybald1]

I always agree with swoop and his comments except this one, I think it's more than minoxidil

 

[Swoop]

PS: I think Follica has something, and after 12 years of research including garnering a spotlight in Nature mag and bothering to secure patents , it's likely to be more than micro-needling with minoxidil.

I hope so. Btw, I never said they will go with micro needling. I think it's going to be a form of wounding (dermabrasion) with minoxidil. The second option that I find most likely is a PGF2a analogue. We will know really soon really. Their registration study will probably tell.

I always agree with swoop and his comments except this one, I think it's more than minoxidil

TRAITOR .