Do androgens DIRECTLY affect the hair follicles?

[freakout]

Comparative studies on level of androgens in hair and plasma with premature male-pattern baldness
Hyo-Jung Bangab, Yoon Jung Yanga, Dong-Seok Lhoa, Won-Yong Leeb, Woo Young Simc, Bong Chul Chunga

Biochemical Roles of Testosterone and Epitestosterone to 5alpha-Reductase as Indicators of Male-Pattern Baldness
http://www.nature.com/jid/journal/v116/ ... 0945a.html

Both studies suggest DIRECT androgen action. Both studies are also in vitro biochemical analysis of test samples and supports the theory that testosterone (T) is converted by the 5?-reductase type II enzyme into DHT 'inside the follicles' - the prevaling Androgenetic Alopecia Theory

Please correct me if im wrong.

Therefore, anywhere these follicles are transplanted, they will continue to shrink in the presence of circulating T.

If thats the case, in an in vivo study, how did the tranplanted follicles, including biopsies of their scalp, of ALL 28 men and 11 women (100% no exceptions) , regrow into terminal in just four months when they were transplanted onto uncastrated male mice?? viewtopic.php?p=611106#p611106

...Therefore, the existence of an inhibitor factor other than androgens...viewtopic.php?p=611106#p611106

In vivo studies are often often described by the maxim in vivo veritas - loosely translated as "the greatest living truth"

In vitro studies DO NOT matter when they contradict with in vivo studies e.g. the benefits of antioxidants supplements is a myth but they were perfect in the test tube.

 

[optimus prime]

Comparative studies on level of androgens in hair and plasma with premature male-pattern baldness
Hyo-Jung Bangab, Yoon Jung Yanga, Dong-Seok Lhoa, Won-Yong Leeb, Woo Young Simc, Bong Chul Chunga

Biochemical Roles of Testosterone and Epitestosterone to 5alpha-Reductase as Indicators of Male-Pattern Baldness
http://www.nature.com/jid/journal/v116/ ... 0945a.html

Both studies suggest DIRECT androgen action. Both studies are also in vitro biochemical analysis of test samples and supports the theory that testosterone (T) is converted by the 5?-reductase type II enzyme into DHT 'inside the follicles' - the prevaling Androgenetic Alopecia Theory

Please correct me if im wrong.

Therefore, anywhere these follicles are transplanted, they will continue to shrink in the presence of circulating T.

If thats the case, in an in vivo study, how did the tranplanted follicles, including biopsies of their scalp, of ALL 28 men and 11 women (100% no exceptions) , regrow into terminal in just four months when they were transplanted onto uncastrated male mice?? viewtopic.php?p=611106#p611106

...Therefore, the existence of an inhibitor factor other than androgens...viewtopic.php?p=611106#p611106

In vivo studies are often often described by the maxim in vivo veritas - loosely translated as "the greatest living truth"

In vitro studies DO NOT matter when they contradict with in vivo studies e.g. the benefits of antioxidants supplements is a myth but they were perfect in the test tube.

Does a mouse have the same amount of androgens as a full grown balding male?

 

[freakout]

Does a mouse have the same amount of androgens as a full grown balding male?

Yes. Same proportions. That's why researchers use mice for research. In that experiment they even used female mice and got the same results as male mice. They also used different strains of mice.

Makes you think, right?

 

[John979]

These are immune difficient mice.

 

[balder]

Off the topic
Balder
your icon is an ouakari?

Yes :woot:

http://en.wikipedia.org/wiki/Uakari

 

[armandein]

Nice ape,
I saw a reference of them in a paper of Hamilton about Pattern Alopecia
"A male pattern baldness in wattled starlings ...
http://onlinelibrary.wiley.com/doi/10.1 ... x/abstract