collegechemistrystudent

[bluechips]

I saw on your "my regimen" that you use/drink grapefruit to increase the effects of dutasteride. Can you tell me more about that? Thanks.

 

[Guest]

I can answer this one because I actually made a thread on this awhile back advocating drinking/eating grapefruit to increase the potency of dutasteride.

"Interactions with drugs

Grapefruit can have a number of interactions with drugs, often increasing the effective potency of compounds. Grapefruit contains naringin and bergamottin, which inhibit the cytochrome P450 isoform CYP3A4 in the liver. It is via inhibition of this enzyme that grapefruit increases the effects of buspirone (Buspar), caffeine, simvastatin, terfenadine, felodipine, nifedipine, verapamil, estradiol, midazolam, tacrolimus, dextromethorphan (significant only at recreational doses), benzodiazepines and ciclosporin. This effect was only discovered after being responsible for a number of deaths due to overdosing on medication."

That's from Wikipedia. You can add dutasteride and finasteride to that list as well. But don't worry about it being unsafe. It's safe to have both with grapefruit.

 

[CCS]

annoying that caffine is on that list.

 

[bluechips]

Do you think there is a difference between drinking fresh grapefruit juice and drinking some 100% Tropicana grapefruit juice.

 

[Guest]

no

 

[Nathaniel]

I can answer this one because I actually made a thread on this awhile back advocating drinking/eating grapefruit to increase the potency of dutasteride.

"Interactions with drugs

Grapefruit can have a number of interactions with drugs, often increasing the effective potency of compounds. Grapefruit contains naringin and bergamottin, which inhibit the cytochrome P450 isoform CYP3A4 in the liver. It is via inhibition of this enzyme that grapefruit increases the effects of buspirone (Buspar), caffeine, simvastatin, terfenadine, felodipine, nifedipine, verapamil, estradiol, midazolam, tacrolimus, dextromethorphan (significant only at recreational doses), benzodiazepines and ciclosporin. This effect was only discovered after being responsible for a number of deaths due to overdosing on medication."

That's from Wikipedia. You can add dutasteride and finasteride to that list as well. But don't worry about it being unsafe. It's safe to have both with grapefruit.

Benzodiazepines? Wow I had no idea grapefruit increased the effects of benzodiazepines.

 

[Sean68]

i was going to try the grapefruit juice idea but i heard somewhere that if you stop taking it with grapefruit then the dutasteride/finasteride wont absorb as well as if you never started with it if you know what i mean. any truth in this?

 

[Guest]

i dont think so.