Clinical Study of FGF-5 Inhibition and Hair Growth from CELLMID

[hellouser]

Info:

Sydney, Australia, April 16, 2015 / B3C newswire / -- Cellmid Limited (ASX: CDY) hasreceived strong positive results in all measured areas of its independently conducted, randomized, blinded and placebo controlled human clinical study of the évolis ONE formulation. The 32 patient study was conducted with Cellmid’s novel and proprietary FGF5 inhibitor formulation, évolis ONE, which is a fully optimised, GMP manufactured and market ready product.Using Gravimetric Analysis1 évolis ONE has shown a statistically significant 80.2% reduction in hair loss over 112 days (16 weeks) with twice daily use. Hair differentiation (or anagen/telogen ratio, a measure of growing versus resting hair follicles) improved with an increase of 44.2% in growing follicles during the same period, as analysed by the Van Scott “hair pluck” method2. Hair release and recovery (overall improvement in hair quality and volume) was quantified by PhotoGrammetrix™3 measurements and has shown an improvement by a statistically significant 143.3%.

The trial was conducted by AMA Laboratories, INC. in New York, a leading independent CRO specialising in dermatological product testing. The efficacy study followed a 51 subject Repeat Insult Patch Test (RIPT) to assess safety by evaluating skin irritation and sensitisation. The safety study, also conducted by AMA Laboratories, resulted in a “zero adverse event” report.
“In addition to the hair count and hair loss measurements the photographs taken during the PhotoGrammetrix™ evaluation demonstrate visible improvement in overall hair quality and volume” added Maria Halasz, CEO of Cellmid. “As this product has active ingredients subject to Cellmid’s recently filed patent application, the results give us multiple opportunities to commercialise this valuable asset” she added.
“These are very exciting and valuable results expected to support stronger clinical hair growth claims of this proprietary product” said Darren Jones, Head of Product Development at Cellmid. “FGF5 is well recognised as the ultimate controller of hair loss. We are excited to be the first on the market with a clinically validated product range addressing FGF5” he added.

Background Cellmid, on behalf of its wholly owned subsidiary Advangen Limited, contracted independent CRO, AMA Laboratories, to conduct a 16 week clinical study in September 2014 to evaluate the efficacy of its novel FGF5 inhibitor formulation, which is subject to patent applications. The key objectives of the clinical study included quantitative assessment of hair loss, hair release and recovery and hair differentiation.
Efficacy of évolis ONE was measured by Gravimetric Determination, Van Scott “Hair Pluck” method and using PhotoGrammetrix™ scientifically matched photography. Visual evaluation was conducted by AMA’s Institutional Review Board.
Individuals included in the study experienced “patterned baldness” of 2 to 4 on the Hamilton-Norwood scale (men) and I-2 to II-2 on the Ludwig scale (women) of hair loss. Study participants were otherwise in general good health and within the healthy weight range, aged 31 to 55 years.

FGF5 and its inhibitors FGF5 is well recognised as the ultimate regulator of hair cycle and hair length in humans4. Expressed by macrophage-like cells surrounding the hair follicle, it acts by triggering the dermal papilla to transition from growing (anagen) to resting (telogen) phase. Overexpression of FGF5 induces hair follicles to undergo premature entry into catagen phase and fall out.
Several groups have been pursuing FGF5 inhibition as a strategy to prevent hair loss and increase hair growth. Cellmid, through its wholly owned subsidiary Advangen Limited, is the first company with a clinically validated FGF5 inhibitor hair growth product on the market.

Source:
https://www.einnews.com/pr_news/260...air-growth-product-using-novel-fgf5-inhibitor

Well.... at least it was trialed on humans this time.

 

[moskva]

Honestly I don't think it's legit. It's just a herb extract if I understand correctly, and they're just saying they have done a human trial, without photos research paper or anything. The research paper link they do provide in their company website turns out to be an ancient japanese one using #MICE dated back in 2006. Everything smells fishy.

- - - Updated - - -

http://www.cellmid.com.au/content_common/pg-evolisproducts.seo
click"clinical study results"

 

[hellouser]

Well, it's almost without a doubt that this is just another shameless group of con artists trying sell more snake oil at the expense of desperate men looking for a legitimate cure for this hell. Here's some more info:

http://www.evolisproducts.com.au/evolis-products/treatment-for-men/evolis-for-men

Ingredients:

evolis tonic for men

Active botanical extracts:

• • Eriobotrya japonica
• • Ginkgo biloba
• • Swertia chirata

INGREDIENTS LIST
PURIFIED WATER, ETHANOL, BUTYLENE GLYCOL, GINKGO BILOBA EXTRACT, ERIOBOTRYA JAPONICA LEAF EXTRACT, PANTHENYL ETHYL ETHER, SWERTIA CHIRATA EXTRACT, GLYCYRRHETINIC ACID, CITRIC ACID, SODIUM CITRATE, MALTODEXTRIN

evolis shampoo for men

Botanical extracts:

• • Sanguisorba officinalis
• • Rosa multiflora
• • Swertia chirata
• • Chlorella Vulgaris
• • Moringa Pterygosperma
• • Eucalyptus Globulus

INGREDIENTS LIST
PURIFIED WATER, SODIUM LAURETH SULFATE, LAURYL BETAINE, DIPROPYLENE GLYCOL, LAURAMIDE DEA, GLYCOL DISTEARATE, SANGUISORBA OFFICINALIS ROOT EXTRACT, ROSA MULTIFLORA FRUIT EXTRACT, SWERTIA JAPONICA EXTRACT, CHLORELLA VULGARIS EXTRACT, MORINGA PTERYGOSPERMA SEED EXTRACT, EUCALYPTUS GLOBULUS LEAF EXTRACT, POLYQUATERNIUM-64, POLYQUATERNIUM-51, SODIUM LAUROYL METHYLALANINE, GLYCEROL, POLYQUATERNIUM-10, SORBITAN STEARATE, POLYSORBATE 80, PEG-5 STEARATE, DIMETHICONE, LAURETH-2, CITRIC ACID, SODIUM CITRATE, BUTYLENE GLYCOL, LAURETH-20, METHYLPARABEN, PROPYLPARABEN, SODIUM SALICYLATE, ALCOHOL (ETHANOL), FRAGRANCES.

How do these companies get away with this LYING?

 

[2tite2014]

why you gotta steal my thunder bro

 

[moskva]

How do these companies get away with this LYING?

The only way to eliminate these snake oil merchants is to bring about a real thing.

 

[2tite2014]

But seriously, I don't know how good this stuff is. There's only 1 study out without before/after photos so it may very well be snake oil.

 

[kirk]

I ignored the other Evolis post because I felt like it was snake oil.

You know that guy nidhogge from various other forums like Immortal hair? Well, he has used this SO substance in versions of his products. I haven't really heard anything positive from it.

This substance has been around for a while as well. I can't find any pictures involving the use of SO including the ones mentioned in that study.

This is a hybrid study containing results on humans and #USELESSMICE.

 

[hellouser]

The only way to eliminate these snake oil merchants is to bring about a real thing.

That would be the ultimate smackdown on these fucking liars.