- Reaction score
- 320
https://www.ingentaconnect.com/content/asp/jbte/2018/00000008/00000001/art00011
In vivo, HFSCs were injected into the dermis of rat vibrissae near a skin defect to detect whether (+)-cholesten-3-one promoted HFSCs to repair the skin wound. The results show that HFSCs were typically cobblestone-like and positive for CD34 and cytokeratin 15. (+)-cholesten-3-one induced proliferation of HFSCs; upregulation of β-catenin, Lef1, c-Myc, and cyclin D1 in HFSCs; and downregulation of GSK-3β and Tcf3
In conclusion, (+)-cholesten-3-one activated the Wnt/β-catenin pathway and accelerated HFSCs to repair skin wound. This compound may offer a new approach for stem cell-based treatment besides conventional therapy.
In vivo, HFSCs were injected into the dermis of rat vibrissae near a skin defect to detect whether (+)-cholesten-3-one promoted HFSCs to repair the skin wound. The results show that HFSCs were typically cobblestone-like and positive for CD34 and cytokeratin 15. (+)-cholesten-3-one induced proliferation of HFSCs; upregulation of β-catenin, Lef1, c-Myc, and cyclin D1 in HFSCs; and downregulation of GSK-3β and Tcf3
In conclusion, (+)-cholesten-3-one activated the Wnt/β-catenin pathway and accelerated HFSCs to repair skin wound. This compound may offer a new approach for stem cell-based treatment besides conventional therapy.