China And The Dutch New Treatment On The Way?

DanielDüsentrieb

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Found this in the comment section from HLC2020. Both articles were posted by the user Netshed. It looks quit interesting so I thought I share his findings here.

China
China calling!
TSG, apoptosis, p53, senescence

Tetrahydroxystilbene Glucoside Effectively Prevents Apoptosis Induced Hair Loss

https://www.ncbi.nlm.nih.gov/m/pubmed/29808162/?i=2&from=p53%20hair

https://www.researchgate.net/publication/324200539_Tetrahydroxystilbene_Glucoside_Effectively_Prevents_Apoptosis_Induced_Hair_Loss/fulltext/5ac56f0da6fdcc051daf2607/324200539_Tetrahydroxystilbene_Glucoside_Effectively_Prevents_Apoptosis_Induced_Hair_Loss.pdf?origin=publication_detail

Pharmacological studies have demonstrated that TSG have multiple biological functions in treating many diseases such as vascular and cardiac remodeling [30, 31], delaying the senescence effect [32], learning and memory disorders [33], and diabetic complication [34]. In this experiment, TSG showed great effects on hair growth. Treatment with TSG resulted in the emergence of new hair shafts and recoveries of the size and numbers of follicles. Few TUNEL+ cells were detected in the dorsal depilated skin treated with TSG. The next step of this experiment is going to find the dose-effect relationship of TSG in hair length and hair recovery ratio and figure out optimal drug concentration and delivery devices with the least side effects.

Taken together, these findings suggested that TSG could inhibit p53, Fas, and Bax induced apoptotic signaling pathway and help to prevent follicles from entering into catagen phase of the hair cycle. TSG may be an alternative medicine for treating hair loss such as alopecia and telogen effluvium.

Use second link, scroll down and download pdf (free)

Dutch

New developments FOXO4-DRI

Cleara Biotech, start up Peter de Keizer, UMC Utrecht Netherlands

https://www.clearabiotech.com

Numeric Biotech, start up Hans van Berkum, UMC Rotterdam Netherlands

http://www.numericbiotech.com

Full English story in one of the major Dutch newspapers:

https://www.volkskrant.nl/wetenschap/the-mouse-that-time-forgot~bf9cc68f/
 
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