Cell Types Promoting Goosebumps Form A Niche To Regulate Hair Follicle Stem Cells

[pegasus2]

https://www.cell.com/cell/fulltext/S0092-8674(20)30808-4

The hair follicle instructs the formation of the APM-sympathetic nerve unit via SHH

APM maintains sympathetic innervation to HFSCs

Sympathetic nerve activates HFSCs via synapse-like contacts and norepinephrine

Cold stimulates not only goosebumps but also hair growth

 

[HelpMyHair!!]

https://www.cell.com/cell/fulltext/S0092-8674(20)30808-4

The hair follicle instructs the formation of the APM-sympathetic nerve unit via SHH

APM maintains sympathetic innervation to HFSCs

Sympathetic nerve activates HFSCs via synapse-like contacts and norepinephrine

Cold stimulates not only goosebumps but also hair growth

Always have thought they were closely related somehow. Any thoughts on how to use this knowledge for a regimen?

 

[Selb]

I actually remember connecting the two since it almost felt like my follicles were awake when I got goosebumps. Now is there a medical way of consistently inducing goosebumps using some topical?

 

[Poppyburner]

'Study Discovers Why Bald People Don’t Get Goose Bumps on Their Scalp
[...]
The [Melbourne University] researchers explain that hair follicles have the unique ability to completely regenerate. “When a hair is plucked, up to 70 per cent of the follicle is destroyed, but when the hair regrows, the follicle regenerates itself,” they say. [...]

"We discovered that when you go bald, part of the problem is because the attachment of the goose bump muscle to the hair follicle is destroyed and replaced by fat,” says Professor Rodney Sinclair, who is head of Dermatology at the University. “You can’t get goose bumps on the scalp when you go bald and you can’t regrow hairs either because the follicles can’t regenerate.”'

https://www.beIgraviacentre.com/blo...d-people-dont-get-goose-bumps-on-their-scalp/


'Although APM attachment to vellus hairs is lost in Androgenetic Alopecia, attachment to terminal hairs remains preserved.'

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158628/


'Tweezing, waxing, and depilatories can make vellus facial hair grow back thicker because they can cause increased blood supply to the root of the hair.'

http://topelectrolysisnyc.com/the-v...ng, and depilatories can,the root of the hair.

 

[pegasus2]

I actually remember connecting the two since it almost felt like my follicles were awake when I got goosebumps. Now is there a medical way of consistently inducing goosebumps using some topical?

Always have thought they were closely related somehow. Any thoughts on how to use this knowledge for a regimen?

Same feeling here. I always felt like it was doing my hair good when I got goosebumps. Turns out it really is.


Use an shh agonist

 

[Selb]

Same feeling here. I always felt like it was doing my hair good when I got goosebumps. Turns out it really is.


Use an shh agonist

Shh agonist? Which do you recommend?

 

[pegasus2]

Shh agonist? Which do you recommend?

I don't recommend any, but that's what will accomplish the job of regenerating the APM. You either use SAG or norepinephrine to mimic this. Norepinephrine will make your hair turn gray. Someone could try procaterol.

 

[TurboFixer]

Is there any company researching this pathway for future treatments?

 

[pegasus2]

Is there any company researching this pathway for future treatments?

Maybe Bayer's prolactin antibody.

 

[Fgsfds]

beta2 agonists are promising

 

[pegasus2]

beta2 agonists are promising

Have you ever tried one? My concern is that too much sympathetic nerve stimulation will make things worse. I don't know what the proper dosage would be. It might be something you only want to use once a week.

 

[Sweuser]

beta2 agonists are promising

Preferably an Alpha1 stimulator, but yes, a lot of them have overlapping effects.

Alpha-r agonists are sold already as eye drops, ex Phenylephrine with maximum effect within 30-60 minutes and fully eliminated after 6 hours(applied in eyes).

It would be interesting to know more of what mimics goosebumps best and its significans in male pattern baldness.

 

[Fgsfds]

Have you ever tried one? My concern is that too much sympathetic nerve stimulation will make things worse. I don't know what the proper dosage would be. It might be something you only want to use once a week.

I know someone who is. Yes tolerance is a concern so you need a short-acting agonist and probably should only use it around needling