CCS, Bryan or Whomever: Do you have the Type I DHT DutGraph?

[doggfather]

I'm talking about the one that shows the level of inhibition of the type I 5-alpha reductase depending upon certain dosages and intake frequencies of dutasteride. I've been researching and I saw CCS post that dutasteride 0.5mg 3x/week will inhibit 18% of type I DHT which I can possibly live with. And then I also see some posts saying that 0.5mg dutasteride 1x/week insignificantly inhibits type I DHT. Would like to see that graph if anyone has it.

 

[Bryan]

This is the one you need. Obviously, you have to do a bit of interpolation to estimate the effect of those in between doses:

http://www.geocities.com/bryan50001/dutasteride2.htm

Bryan

 

[doggfather]

Thanks for the graph Bryan. Question though, from the graph how has it been determined that taking 0.5mg of dutasteride either 2x/week or 3x/week would only inhibit 18% of type I 5-alpha reductase, and how 0.5mg of dutasteride 1x/week would inhibit a negligible amount of type I 5-alpha reductase? I fail to see how you can determine that from those graphs.

 

[Bryan]

Thanks for the graph Bryan. Question though, from the graph how has it been determined that taking 0.5mg of dutasteride either 2x/week or 3x/week would only inhibit 18% of type I 5-alpha reductase,

I believe it was collegechemistrystudent who made that estimate. Obviously he tried to interpolate beween the 0.1 mg/day dose curve and the 1 mg/day dose curve, and came up with that estimate. He probably isn't too far off the mark.

and how 0.5mg of dutasteride 1x/week would inhibit a negligible amount of type I 5-alpha reductase? I fail to see how you can determine that from those graphs.

Well, 0.5 mg/week is only the equivalent of 0.07 mg/day, which is even less than the minimum dose they actually have in that graph (0.1 mg/day). So it would have even less of an effect than what you see for that uppermost curve in the graph.

Bryan