BRYAN: Please explain your graph

[Guest]

I refer to: http://www.geocities.com/bryan50001/dutasteride3.htm

According to that.. You reach 95% inhibition quicker on LOW LOW Dose of Dutasteride, than you would on much higher doses?

How does this work?

 

[Bryan]

The graph doesn't say anything at all about inhibition. It's just about the time it takes to achieve steady-state at various doses of the drug, which is a completely separate issue. Generally speaking, lower doses achieve steady-state faster than higher doses, although a plateau is reached at both very low and very high doses.

 

[Guest]

The graph doesn't say anything at all about inhibition. It's just about the time it takes to achieve steady-state at various doses of the drug, which is a completely separate issue. Generally speaking, lower doses achieve steady-state faster than higher doses, although a plateau is reached at both very low and very high doses.

Ahhhhh grazies senor`.

 

[dut]

It's just about the time it takes to achieve steady-state at various doses of the drug.

Almost... It's actually about the number of days it would take to achieve a certain PERCENTAGE of plateau as a function of dose. As you know from a previous thread, it would be difficult for most people to determine the number of days it takes to achieve the so called 'steady-state' amount of the drug in the blood stream. Like yourself, most people who attempt to extrapolate the graphs would significantly under estimate how long it would take to reach the plateau.

There is a thread somewhere on the forum where bryan and myself discussed this at length. Without confusing people with the maths, as a rough guide it takes appoximately 5 - 6 x the half life to reach 99% of plateau.

Depending on where you get the half life info from, it would take 5 x 35 days = 175 days at 0.5mg per day (standard dose) or 5 x 4 days = 20 days (at the commonly discussed dose of 2 x 0.5mg per week).