Breezula update 2022 June apparently they are doing trials very soon

[cloudsanrain]

When or if their is a cure most isn't going to afford it anyway .

 

[Modill]

well i had a precondition and i attribute it to that getting worse, quite unlikely that a 15% reduction in dht can cause this tissue change. i talked to 2 top andrologist and they said this reduction in dht is not even significant to differentiate it from daily fluctations.

however i dont deny that long term oral finasteride can potentially do this and did some thjngs like that to me too. however finasteride IS not dose dependent, you take 0.05mg of finasteride you akmost get the same effect as 5mg oral, 100 times the dose so microdosing finasteride doesnt really work especially orally. however and thats my main point, receptor antagonists are very much dose dependent, in fact aside from AR affinity the concentration is a very critical aspect as every AA molecule is competing with very high affine DHT at the receptor and a low concentration can in noe way outcompete normal AR signaling. in zhat rrgard finasteride is much more powerful than an AA.

both can certainly cause sides but i find it highly questionably that microdose, not sure what the actual dose was, can cause this.

for example there is likely a massive difference between taking 0.5% pyrilutamide twice a day as by the kintor studies vs taking just 0.2% once a day which would be 1/5th of the dose. in contrast, taking 1/5th of the oral finasteride 1mg dose basically does the exact same thing


in that regard receptor antagonists and 5ARi have a very strong difference. the amount of AR signaling interference can thus be assumed to be compareable if not smaller than daily fluctations you see e.g in the morning T is higher and you have higher libido then. however you dont jjst have sexual dysfunction or a completely nuked libido after not sleeping well for a night even though this probabky reduces your testosterone quite significantly.

in my case i got one Testosterone test well rested snd it was 580ng and one not well rested at 370ng but my libido was basically the same. it would not make a lot of biological sense for a small interference to cause a drastic effect. e.g finasteride -70% is NOT a small interference especially bc other sex hormones like estrogen are severely altered. but micro dose of an androgen receptor antagonist are a lot milder for the body

Blablabla… you can have “unlikely” side effects, but other people taking hard and experimental drugs cannot.

 

[Min0]

update on eucapil : unfortunately, with long term use, my libido got reduced more and more.

i had to stop, now i'm 5 days off and still didn't recover.

i think this is the end of the fight. i did all i could, but i think i'm done.

 

[Modill]

update on eucapil : unfortunately, with long term use, my libido got reduced more and more.

i had to stop, now i'm 5 days off and still didn't recover.

i think this is the end of the fight. i did all i could, but i think i'm done.

That means it works for hair. How long did you use it?

 

[badnewsbearer]

another day at sideeffectalk forum. so locally its not enough to alter androgenic signaling enough zo cause a biological change but systemically, where additionally to its weakness, the super quick metabolism comes into play it is suddenly strong enough to cause a reduction in libido that then even lasts after quitting? biologically that is very very unlikely to actually occur. it makes no actual sense.

the fluctation in androgens that one experiences on a daily or even hourly basis is so much more severe than anything fluridil does. and 5 days after quitting its completely been erased from the system many times, thats like 20 half lives. then youd have libido issues after anything in daily live, had a bad meal, lower libido. slept 1 hour less? thats going to affect androgens more than fluridil. i got my testosterone measured 4 times and saw anything from 370-630ng/dL and my libido was always the same. so a doubling in testosterone doesnt change libido but a super weak topically applied AAnukes your libido for even 5 days after quitting. totally makes sense and plausible

 

[Southcity94]

another day at sideeffectalk forum. so locally its not enough to alter androgenic signaling enough zo cause a biological change but systemically, where additionally to its weakness, the super quick metabolism comes into play it is suddenly strong enough to cause a reduction in libido that then even lasts after quitting? biologically that is very very unlikely to actually occur. it makes no actual sense.

the fluctation in androgens that one experiences on a daily or even hourly basis is so much more severe than anything fluridil does. and 5 days after quitting its completely been erased from the system many times, thats like 20 half lives. then youd have libido issues after anything in daily live, had a bad meal, lower libido. slept 1 hour less? thats going to affect androgens more than fluridil. i got my testosterone measured 4 times and saw anything from 370-630ng/dL and my libido was always the same. so a doubling in testosterone doesnt change libido but a super weak topically applied AAnukes your libido for even 5 days after quitting. totally makes sense and plausible

Despite being super sarcastic and a little too agressive for my taste, I kinda agree.
There are a lot of things that influence your mood and also how you feel. Libido is not Something that you can directly compare.
If I sleep less, If I drink too much, if Im dealing with heartbreak, if the weather sucks, if Im stressed, If my mental health is not on point, etc, my Libido is less.
Thats normal, so its difficult to determine Fluridil as the cause main cause for your Problems. Doesnt mean that it is not possible but the mind is a powerful thing. Take this from someone who has dealt with anxiety...

 

[Modill]

another day at sideeffectalk forum. so locally its not enough to alter androgenic signaling enough zo cause a biological change but systemically, where additionally to its weakness, the super quick metabolism comes into play it is suddenly strong enough to cause a reduction in libido that then even lasts after quitting? biologically that is very very unlikely to actually occur. it makes no actual sense.

the fluctation in androgens that one experiences on a daily or even hourly basis is so much more severe than anything fluridil does. and 5 days after quitting its completely been erased from the system many times, thats like 20 half lives. then youd have libido issues after anything in daily live, had a bad meal, lower libido. slept 1 hour less? thats going to affect androgens more than fluridil. i got my testosterone measured 4 times and saw anything from 370-630ng/dL and my libido was always the same. so a doubling in testosterone doesnt change libido but a super weak topically applied AAnukes your libido for even 5 days after quitting. totally makes sense and plausible

Oh yeah? And what about you? You have stopped finasteride for more than a year and still have not recovered your libido or erections. Your opinion of desperate hater doesn’t count

 

[badnewsbearer]

also androgens are one among many many molecular processes that affect libido. also there should be a dose dependent dependency at the very least, its not like any change happens and your libido is just nuked. case in point, studies on men with hypogonadism where testosterone shows a dose dependent improvement up to a certain point. or having higher libido in the morning because your T levels are 40% highrr(nothing fluridil would ever achieve). so microdosing an antagonist is very unlikely going to significsntly affect the androgen signaling on the receptor site. you are carefullly observing your libido everyday, even suggesting pyrilutamide was able to change the growth of the beard even after quitting. i find that absurd to be honest. but this is sideeffectalk so anything that doesnt even change those parameters on paper beyond a statistical significsnt amount nukes your libido

 

[badnewsbearer]

Oh yeah? And what about you? You have stopped finasteride for more than a year and still have not recovered your libido or erections. Your opinion of desperate hater doesn’t count

my libido was never affected on finasteride. case in point that when i took 1mg oral finasteride and also cialis my functioning was perfect. but cialis does not alter libido itself so the libido seemed to habe been there and just the anxiety and depression i experienced from the ED is what lowered jt. i took cialis and my libido spiked dramatically. thats when i learned how mucb of it is controlled by factors other than androgens. the ED is weird but i had that to some degree ever since i quit oral finasteride. i dont think its reasonable to compare finasteride to fluridil. furthermore 5AR inhibitors are not dose dependent, antagonists are. but think what you want. this entire thread ans forum is completely sick

 

[Hope111]

my libido was never affected on finasteride. case in point that when i took 1mg oral finasteride and also cialis my functioning was perfect. but cialis does not alter libido itself so the libido seemed to habe been there and just the anxiety and depression i experienced from the ED is what lowered jt. i took cialis and my libido spiked dramatically. thats when i learned how mucb of it is controlled by factors other than androgens. the ED is weird but i had that to some degree ever since i quit oral finasteride. i dont think its reasonable to compare finasteride to fluridil. furthermore 5AR inhibitors are not dose dependent, antagonists are. but think what you want. this entire thread ans forum is completely sick

Why did you take cialis if you didn't have a problem?

 

[badnewsbearer]

Why did you take cialis if you didn't have a problem?

because i had ED on oral finasteride. i took it and my libido was completely restored. because libido is a complicated process is what i am trying to say. cialis doesnt alter it but not being depressed about ED did

 

[Hope111]

because i had ED on oral finasteride. i took it and my libido was completely restored. because libido is a complicated process is what i am trying to say. cialis doesnt alter it but not being depressed about ED did

nocebo effect then.
I totally agree with you that libido and dysfunction can go to hell with negative thinking.
Can you tell how old you were then?
Because I think that finasteride does not affect until you reach a certain age

 

[badnewsbearer]

nocebo effect then.
I totally agree with you that libido and dysfunction can go to hell with negative thinking.
Can you tell how old you were then?
Because I think that finasteride does not affect until you reach a certain age

23

 

[Modill]

23

You told us you will try fluridil. You finally bought it?

 

[Modill]

nocebo effect then.
I totally agree with you that libido and dysfunction can go to hell with negative thinking.
Can you tell how old you were then?
Because I think that finasteride does not affect until you reach a certain age

This is incorrect. Finasteride can affect you at any age.

 

[Modill]

my libido was never affected on finasteride. case in point that when i took 1mg oral finasteride and also cialis my functioning was perfect. but cialis does not alter libido itself so the libido seemed to habe been there and just the anxiety and depression i experienced from the ED is what lowered jt. i took cialis and my libido spiked dramatically. thats when i learned how mucb of it is controlled by factors other than androgens. the ED is weird but i had that to some degree ever since i quit oral finasteride. i dont think its reasonable to compare finasteride to fluridil. furthermore 5AR inhibitors are not dose dependent, antagonists are. but think what you want. this entire thread ans forum is completely sick

You are the only sick on this forum. Not only sick, but also stupid arrogant and frustrated hater.

I will tell you something: meds that block DHT to improve hair (finas, dutas, CB, pyri, RU, fluridil, etc.), pills or topical, will produce terrible sexual side effects. END.

There is no solution better than finasteride, and that is sad. Maybe “nioscam”, but who knows.

 

[badnewsbearer]

You told us you will try fluridil. You finally bought it?

of course not. look at the studies of fluridil. it is so weak as an anti androgen, it has shown almost no improvement, worse than some plant herb juice someone could probably put on their head and get better results. thats the thing, if it is so incredibly weak its hard to imagine it can cause substabtial physical changes especially considering its fast degrading properties. but you have your view already

 

[badnewsbearer]

You are the only sick on this forum. Not only sick, but also stupid arrogant and frustrated hater.

I will tell you something: meds that block DHT to improve hair (finas, dutas, CB, pyri, RU, fluridil, etc.), pills or topical, will produce terrible sexual side effects. END.

There is no solution better than finasteride, and that is sad. Maybe “nioscam”, but who knows.

you are insane in my opinion

 

[Hope111]

This is incorrect. Finasteride can affect you at any age.

Of course it can affect any age, but I mean that it is not the same to affect the hormones of an adolescent who is thinking about sex all day than at 30 years of age, for example. I have friends who do not have alopecia and they tell me that their libido is not the same as it was a few years ago. If you add to that the reduction that the pill produces...

 

[Min0]

it has been almost a month, i still didn't get my libido back.
this is the longest i've suffered low libido, i recovered off pyri and CB much faster than fluridil, so it's either fluridil has wors sides than them when taken long enough. or the damage to the libido accumulates with time and even low potency anti androgens will f*** you up on the long run

i just booked another appointment with my doctor, hope he refers me to a specialist (endocrinologist perhaps ?) time to do some real tests because this shitty state is taking longer than expected.

i'm getting even depressed without libido. i guess that's what old people feel.