blood circulation

[wak8]

Is it true all the articles that say that hair loss is not only because of the DHT, but also because there is not enough blood circulation in your head?

 

[The Gardener]

Unscientific response here, but, I would think that this is NOT the case.

From my understanding, blood circulation is more thourough in the head than it is in any other organ of the body, perhaps save the lungs and heart. Head wounds of any kind are usually quite bloody as compared to a similar wound in another part of the body. Just think about how much a simple shaving knick bleeds, as compared to a similar knick on your elbow or knee. This is because the human body has evolved as such to make sure that the brain and the sensory organs are awash in blood, and to make sure that even if the head takes a blood-drawing wound, there is still plenty of pressure left to ensure survival of these crucial functions.

 

[Guest]

There is conflicting info.

If it was blood flow, then standing on your head and exercise should cure male pattern baldness. Neither of these work.

But, minoxidil supposedly increases blood flow to your follicles?

 

[ShedMaster]

Is it true all the articles that say that hair loss is not only because of the DHT, but also because there is not enough blood circulation in your head?

I don't know the exact science behind this, but the opposition would say.. if that is true then why does transplanted hair follicles survive when moved into an area of the scalp which supposedly has lower blood circulation.

 

[George Costanza]

I don't know the exact science behind this, but the opposition would say.. if that is true then why does transplanted hair follicles survive when moved into an area of the scalp which supposedly has lower blood circulation.

Because the transplanted hair doesn't have dht receptor sites? I think your scalp circulation to the head does get worse as you age and with more and more dht forming and attaching to your follicles, even less nutrients get to the follicles. Even with circulation getting worse as you age, I'll bet it wouldn't be enough to cause much hair loss if not for dht. Just my theory.

I've also heard that improved circulation to the scalp ca also help cleanse the follicles of dht.[/quote]

 

[Guest]

From Dr.Pickart:


Miniaturization of hair follicles and diminution of blood supply

The combination of various hormones, diseases, or injuries, and immune effects progressively "miniaturizes" the involved hair follicle. The smaller follicle produces a smaller, thinner hair and has a progressively The increase in hair follicle size and the rate of hair growth caused by the administration of copper-peptides may be due to their causing blood flow changes that provide adequate nutrients to the follicle for strong hair growth.shorter growth cycle. The hair becomes shorter and finer with each hair cycle until it finally becomes "peach-fuzz". Thus, pattern loss is actually more a problem of replacement than of loss.

A major cause of this miniaturization appears to due to the development of striking changes in capillaries surrounding the hair follicles. Comprehensive surveys of the male scalp from birth to senescence find that very significant changes in the structure of the blood vessels of the scalp. The number of the blood capillary loops supplying the hair follicle is greatly diminished. The inadequate subepidermal circulation that can develop as males age does not provide a rich nutrition for the follicle. Strong hair growth requires a large flow of nutrients such as such as vitamins, minerals and amino acids so that the follicle can actively synthesize new hair.

Blood flow impairments to the follicle, and their reversal, may explain why the administration of copper peptides (such as Folligen and Tricomin) to the scalp increase hair growth and increase the size of hair shafts. It has long been known that certain copper-peptide complexes strongly stimulate angiogenesis or new blood vessel formation. In laboratory hair-growth models using mice, the copper-peptides in Folligen or tricomin increase hair follicle volume by 5 to 8-fold. It is likely that these copper-peptides also increase the volume of human hair follicles, although an increase is likely to be smaller than the change in mice. Folligen can be found at
http://www.folligen.com and Tricomin at http://www.tricomin.com/.

 

[Bryan]

Is it true all the articles that say that hair loss is not only because of the DHT, but also because there is not enough blood circulation in your head?

Heh. Here's a scan of a study which found that actually REDUCING blood flow to the scalp (by tying-off arteries) increased hairgrowth:

http://www.geocities.com/bryan50001/artery_ligature.htm (scalp artery ligation study)

Bryan

 

[Guest]

Is it true all the articles that say that hair loss is not only because of the DHT, but also because there is not enough blood circulation in your head?

Heh. Here's a scan of a study which found that actually REDUCING blood flow to the scalp (by tying-off arteries) increased hairgrowth:

http://www.geocities.com/bryan50001/artery_ligature.htm (scalp artery ligation study)

Bryan

Intriguing but not something I would rush out and try. HOWEVER, it does point towards controlling sebum production as a method to combat hairloss. In that regard, the various shampoos such as TGEL and the like certainly seemed vindicated and indicated.

I wonder if daily use is really the way to go. If memory serves, daily use of TGEL almost shuts off the production of sebum. Does that sound right to you Brian??

 

[cyberprimate]

it does point towards controlling sebum production as a method to combat hairloss. In that regard, the various shampoos such as TGEL and the like certainly seemed vindicated and indicated.

i don't understand how a shampoos actually modifies the amount of sebum production. I understand the scalp can be made drier (less oily) with a shampoo, but how about the PRODUCTION of sebum itself?

 

[Guest]

it does point towards controlling sebum production as a method to combat hairloss. In that regard, the various shampoos such as TGEL and the like certainly seemed vindicated and indicated.

i don't understand how a shampoos actually modifies the amount of sebum production. I understand the scalp can be made drier (less oily) with a shampoo, but how about the PRODUCTION of sebum itself?

See below:


Department of Dermatopathology, University of Liege, Belgium.

BACKGROUND: The pathogenesis of androgenic alopecia is not fully understood. A microbial-driven inflammatory reaction abutting on the hair follicles might participate in the hair status anomaly. OBJECTIVE: The aim of our study was to determine if ketoconazole (KCZ) which is active against the scalp microflora and shows some intrinsic anti-inflammatory activity might improve alopecia. METHOD: The effect of 2% KCZ shampoo was compared to that of an unmedicated shampoo used in combination with or without 2% minoxidil therapy. RESULTS: Hair density and size and proportion of anagen follicles were improved almost similarly by both KCZ and minoxidil regimens. The sebum casual level appeared to be decreased by KCZ. CONCLUSION: Comparative data suggest that there may be a significant action of KCZ upon the course of androgenic alopecia and that Malassezia spp. may play a role in the inflammatory reaction. The clinical significance of the results awaits further controlled study in a larger group of subjects.

Publication Types:
Clinical Trial
Controlled Clinical Trial

 

[Guest]

Acta Derm Venereol. 1980;60(2):166-69. Related Articles, Links


The effect of zinc on the sebum secretion rate.

Demetree JW, Safer LF, Artis WM.

In accordance with a randomized double-blind experimental design, capsules of zinc sulfate, 440 mg total daily dose, and lactose placebo were administered orally to 10 normal Caucasian males for 3 weeks. Sebum secretion rates and serum zinc levels were determined prior to and following treatment. There was a statistically significant change in the before and after mean sebum secretion rates of the zinc group when compared with those of the placebo group (p less than 0.028). The results of this preliminary study indicate that supplemental zinc sulfate may reduce the quantity of skin-surface sebum. Further investigation is warranted.
Publication Types:
Clinical Trial
Randomized Controlled Trial

 

[cyberprimate]

The thing is i really don't understand the connection between levels of dht in follicles, sebum production, and this microbial-driven inflammatory reaction. What starts what? Is it a chain of events or are these 3 observations independant phenomena? Are finasteride and minoxidil acting on 2 different stages of this chain of events?

The more i read about it the more mysterious and complex male pattern baldness it looks.

 

[Mikey]

"your scalp is the part of the body that recieves the most bloodyflow and thats why the blood circulation theory is bogus"

Spencer Kobren- The Bald Truth



PS....... Hebsmith is a cockpolish

 

[Guest]

The thing is i really don't understand the connection between levels of dht in follicles, sebum production, and this microbial-driven inflammatory reaction. What starts what? Is it a chain of events or are these 3 observations independant phenomena? Are finasteride and minoxidil acting on 2 different stages of this chain of events?

The more i read about it the more mysterious and complex male pattern baldness it looks.

Keep in mind that this is all THEORY and the theory does not perfectly explain all of the observations within male pattern baldness.

Yes, minoxidil and propecia are directed towards two diff parts of the male pattern baldness cycle. And, nizoral and TGEL are directed at yet a third.

So, that is why we normally recommend,

A growth stimulant=minoxidil
A DHT inhibitorie, propecia, spironolactone, fatty acids, maybe folligen
An anti-inflammatory, ie, nizoral, TGEL, folligen etc.

And the often work fairly well when combined.

Hope that helps a bit.

 

[Guest]

"your scalp is the part of the body that recieves the most bloodyflow and thats why the blood circulation theory is bogus"

Spencer Kobren- The Bald Truth



PS....... Hebsmith is a cockpolish

Spencer is oversimplying. The penis has tons of "bloodflow" but often doesn't fill with blood in order to create an erection.

Hmmm :hairy:

 

[cyberprimate]

the male pattern baldness cycle

so you think there IS an male pattern baldness cycle?

How likely is it that THE motion starter of that cycle is the creation of large amount of dht in the follicles and not the other moments of that cycle? Would it be THE starting point of that male pattern baldness cycle?

 

[Guest]

"your scalp is the part of the body that recieves the most bloodyflow and thats why the blood circulation theory is bogus"

Spencer Kobren- The Bald Truth



PS....... Hebsmith is a cockpolish

PS...... Mike2003 is a EaterAndPackerFudge

 

[Guest]

"your scalp is the part of the body that recieves the most bloodyflow and thats why the blood circulation theory is bogus"

Spencer Kobren- The Bald Truth



PS....... Hebsmith is a cockpolish

Perhaps someone should send the following to Spencer. It is a bit more complex than his theory on circulation!

From Dr. Pickart

Skin Remodeling Starts with Hair Follicles
Skin remodeling starts with the hair follicles. The body's signal for remodeling first activate the systems that break down damaged proteins and remove damaged skin lesion. Various proteins (proteolytic enzymes) start braking down scars and damaged tissue . Then the signals enlarge the hair follicles in the skin area to be rebuilt. New skin cells arise from the hair follicle and migrate into the surrounding skin area.

This effect was first noted about 50 years ago during World War II. It was observed, in patients with severe burns and burn scars, that if hair follicles began growing at the edge of the burned skin, then the was an excellent prognosis for removal of the scarred skin and its replacement by healthy, normal skin. If the follicles were enlarging, the healing was poor and the burn scars remained.

Later, in 1985, I found that copper peptides not only stimulated healing of wounds but also increased the size of the hair follicles near the wounds. The copper peptides were not hair growth stimulators, per se, but did increase the hair follicle size and vitality.

In recent years, it has been established that genetic modifications in mice that stimulate skin remodeling also increase hair follicle size (Fuchs 1998). Genes such as sonic hedgehog (Sato et al 2001, Nanba et al 2003, Oro et al 2003. Mill eta al 2003), catinin (Huelsken 2001, Van Mater et al 2003), Wnt (Stenn 2001) and Noggin (Botchkarev 2001) all enhance hair follicles then produce remodeling. Role of Sonic hedgehog signaling in epithelial and mesenchymal development of hair follicles in an organ culture of embryonic mouse, Nanba D, Nakanishi Y, Hieda Y., Dev Growth Differ. 2003 Jun;45(3):231-9

(Transient activation of beta -catenin signaling in cutaneous keratinocyte is sufficient to trigger the active growth phase of the hair cycle in mice, Van Mater D, Kolligs FT, Dlugosz AA, Fearon ER., Genes Dev. 2003 May 15;17(10):1219-24; Hair cycle regulation of Hedgehog signal reception., Oro AE, Higgins K., Dev Biol. 2003 Mar 15;255(2):238-48, Establishment of cadherin-based intercellular junctions in the dermal papilla of the developing hair follicle., Nanba D, Nakanishi Y, Hieda Y., Anat Rec. 2003 Feb 1,270A(2):97-102; Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development., Mill P, Mo R, Fu H, Grachtchouk M, Kim PC, Dlugosz AA, Hui CC., Genes Dev. 2003 Jan 15;17(2):282-94; Effect of adenovirus-mediated expression of Sonic hedgehog gene on hair regrowth in mice with chemotherapy-induced alopecia., Sato N, Leopold PL, Crystal RG., J Natl Cancer Inst. 2001 Dec 19:93(24):1858-64; Noggin is required for induction of the hair follicle growth phase in postnatal skin., Botchkarev VA, Botchkareva NV, Nakamura M, Huber 0, Funa K, Lauster R, Paus R Gilchrest BA., FASEB J. 2001 Oct; 15(12):2205-14; beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin., Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W., Cell. 2001 May 18;105(4):533-45; Controls of hair follicle cycling, Stenn KS, Paus R, Physiol Rev. 2001 Jan:81(1):449-494; Beauty is skin deep: the fascinating biology of the epidermis and its appendages., Fuchs E., Harvey Lect. 1998-99:94:47-77)



--------------------------------------------------------------------------------








Top Figure. Hair follicle before remodeling signal.





Middle Figure. The remodeling signal increases the size of the hair follicles.





Bottom Figure. The enlarged hair follicle begins to produce new skin cells that migrate into the surrounding skin and rebuild the skin.















--------------------------------------------------------------------------------

GHK-Cu Analogs and Stimulation of Hair Growth
Certain analogs of GHK-Cu have the property of enlarging hair follicles and stimulating hair growth. These analogs have more fat-like character than GHK-Cu. This increase in fat-like properties is obtained by either chemically synthesizing fatty acids into the GHK molecule or attaching amino acid residues such as alanine, phenylalanine or leucine to the basic GHK structure.

These analogs originally arose in an attempt to create GHK-Cu analogs which would be retained in body tissues for longer periods of time. However, it was noted that - while such analogs were superior wound healing agents - they also markedly increased hair growth around the periphery of experimental wounds in mice.

These hair stimulating analogs were created by Drs. Steven Lovejoy, Loren Pickart and Boris Weinstein. There is some disinformation about these analogs which is published by Procyte Corporation which states that such hair stimulating GHK-Cu analogs were "discovered by scientists at Procyte Corporation". Such analogs were discovered before Procyte Corporation existed.

Skin repair and hair growth enhancement effects are closely linked. New skin appears to arise from the hair follicle. Certain products based on Iamin can be used to both repair skin, increase hair follicle size, and stimulate hair growth. As a person ages, our hair follicles get smaller, producing thinner hair shafts.

A major cause of hair follicle miniaturization appears to be due to the development of striking changes in capillaries surrounding the hair follicles. Comprehensive surveys of the male scalp from birth to senescence find very significant changes in the structure of the blood vessels of the scalp. The number of the blood capillary loops supplying the hair follicle is greatly diminished. The inadequate subepidermal circulation that can develop as males age does not provide a rich nutrition for the follicle. Strong hair growth requires a large flow of nutrients such as such as vitamins, minerals and amino acids so that the follicle can actively synthesize new hair.

Blood flow impairments to the follicle, and their reversal, may explain why the administration of copper peptides (such as Folligen and Tricomin) to the scalp increases hair growth and increase the size of hair shafts. It has long been known that certain copper-peptide complexes strongly stimulate angiogenesis or new blood vessel formation. The increase in hair follicle size and the rate of hair growth caused by the administration of copper-peptides may be due to their causing blood flow changes that provide adequate nutrients to the follicle, producing faster growing hair with thicker hair shafts.

Copper ion complexed with certain peptides has both skin repair and hair growth enhancement effects. Examples of this are Folligen (from Skin Biology), and Tricomin and GraftCyte (from ProCyte Corporation).









The skin of the mouse to the left was shaved, then treated in three spots with Folligen. The result is a much more rapid hair growth (the three circular patches of hair) in the three spots treated with Folligen. While human hair growth will not respond nearly as dramatically as in mice, skin health and hair follicle function are closely interrelated. New skin appears to arise from the hair follicle. As a person ages, our hair follicles get smaller, producing thinner hair shafts. The blood circulation system that supplies nutrients and oxygen to the hair follicle send fewer blood vessels to the hair follicle, thus inhibiting the vital flow of nutrients to the hair follicle. Copper-peptide complexes improve skin health and a more healthy skin increases the blood vessel network to the hair follicles resulting in larger follicles that grow hair faster with thicker hair shafts.













In the microscopic images to the left, the magnifications are identical. The top photo is mouse skin untreated with copper-peptides. The bottom photo is mouse skin treated with copper-peptides. Note the larger hair follicles (the elongated purple columns) in the lower photo, the increased content of subcutaneous fat in the skin (the white material in the center of the skin), and the increased thickness of the skin. When we are young, we have a layer of fat under the skin (part of "baby fat") which is greatly reduced as we age. Hair researchers have noted the accumulation of this fat around healthy follicles that are vigorously growing hair, and its relative lack iaround dormant follicles, have postulated that these cells serve a supportive function for the hair follicle. In animal studies, copper peptides have reduced or stopped the hair loss associated with chemotherapy for cancer. It must be emphasized that effects in humans on hair follicle health are not as dramatic.












New Hair Follicle Formation?







At times, copper-peptides can apparently induce a proliferation of hair follicles, although this phenomena is difficult to reproduce on a consistent basis. The photograph on the top is a microscopic field of mouse hair follicles in an animal treated only with saline. The photograph on the bottom is a similar area of mouse skin treated with copper-peptides and which has a much higher density of hair follicles. Individual experiments on hair follicle multiplication are consistent, that is, the effect is actual when it occurs, but repeated results are difficult to obtain. The variability may be due to different timing in the hair growth cycle or slight changes in the type of, or formulation of, the copper-peptide preparations.

Such experiments strongly suggest that, under certain circumstances, new hair follicle formation can be induced in adult animals.