Noisette
Established Member
- Reaction score
- 1,341
Doctor Yuval Ramot wrote something interested about this study " Promotion of hair growth by newly synthesized ceramide mimetic compound".
" Sphingolipids have been postulated to take part in the regulation of hair follicle cycling. Therefore, Park et al have investigated the effects of a new psudoceramide, called bis-oleamido isopropyl alcohol (BOI), on hair growth in several models. In an ex vivo model, BOI increased hair elongation of human occipital scalp hair follicles in culture. In addition, topical application of BOI on shaved dorsal skin of C57BL/6 mice resulted in premature anagen onset when compared to vehicle. When dermal papilla cells in culture were treated with BOI, increased levels of sphingolipids were observed in comparison to the vehicle-treated cells, suggesting that the hair growth promoting effects of BOI might be mediated by stimulation of do novo synthesis of sphingolipids in dermal papilla cells. While these data should be confirmed by additional studies, and the underlying mechanisms for hair growth should be further elucidated, BOI seems to be a new promising therapeutic topical modality for hair loss. "
The study : www.ncbi.nlm.nih.gov/pubmed/28711498
Abstract
Based on the crucial roles of ceramides in skin barrier function, use of ceramides or their structural mimetic compounds, pseudoceramides, as cosmetic ingredients are getting more popular. While currently used pseudoceramides are intended to substitute the structural roles of ceramides in stratum corneum, development of bioactive pseudoceramides has been repeatedly reported. In this study, based on the potential involvement of sphingolipids in hair cycle regulation, we investigated the effects of newly synthesized pseudoceramide, bis-oleamido isopropyl alcohol (BOI), on hair growth using cultured human hair follicles and animal models. BOI treatment promoted hair growth in cultured human hair follicles ex vivo and induced earlier conversion of telogen into anagen. Although we did not find a significant enhancement of growth factor expression and follicular cell proliferation, BOI treatment resulted in an increased sphinganine and sphingosine contents as well as increased ceramides contents in cultured dermal papilla (DP) cells. Taken together, our data strongly suggest that biologically active pseudoceramide promotes hair growth by stimulating do novo synthesis of sphingolipids in DP cells.
" Sphingolipids have been postulated to take part in the regulation of hair follicle cycling. Therefore, Park et al have investigated the effects of a new psudoceramide, called bis-oleamido isopropyl alcohol (BOI), on hair growth in several models. In an ex vivo model, BOI increased hair elongation of human occipital scalp hair follicles in culture. In addition, topical application of BOI on shaved dorsal skin of C57BL/6 mice resulted in premature anagen onset when compared to vehicle. When dermal papilla cells in culture were treated with BOI, increased levels of sphingolipids were observed in comparison to the vehicle-treated cells, suggesting that the hair growth promoting effects of BOI might be mediated by stimulation of do novo synthesis of sphingolipids in dermal papilla cells. While these data should be confirmed by additional studies, and the underlying mechanisms for hair growth should be further elucidated, BOI seems to be a new promising therapeutic topical modality for hair loss. "
The study : www.ncbi.nlm.nih.gov/pubmed/28711498
Abstract
Based on the crucial roles of ceramides in skin barrier function, use of ceramides or their structural mimetic compounds, pseudoceramides, as cosmetic ingredients are getting more popular. While currently used pseudoceramides are intended to substitute the structural roles of ceramides in stratum corneum, development of bioactive pseudoceramides has been repeatedly reported. In this study, based on the potential involvement of sphingolipids in hair cycle regulation, we investigated the effects of newly synthesized pseudoceramide, bis-oleamido isopropyl alcohol (BOI), on hair growth using cultured human hair follicles and animal models. BOI treatment promoted hair growth in cultured human hair follicles ex vivo and induced earlier conversion of telogen into anagen. Although we did not find a significant enhancement of growth factor expression and follicular cell proliferation, BOI treatment resulted in an increased sphinganine and sphingosine contents as well as increased ceramides contents in cultured dermal papilla (DP) cells. Taken together, our data strongly suggest that biologically active pseudoceramide promotes hair growth by stimulating do novo synthesis of sphingolipids in DP cells.
