Bayer Prolactin Receptor Antibody For Male And Female Pattern Hair Loss

[FollicleGuardian]

Let's hope SMI will be enough but I'm not sure as pegasus already stated before:


There is SMI-1 and SMI-6 that @FollicleGuardian found for a cheap price. It's not the same though. Per the patent, competitive antagonists of the receptor are ineffective in the hair follicle because concentrations of prolactin are too high since it's produced within the hair follicle, and prolactin has a higher binding affinity for the receptor than the antagonists.




This might be why the small molecule antagonists don't include hair loss as a potential indication in the patent.

The antibody is a non-competitive inhibitor, meaning that it doesn't have to outcompete prolactin for receptor binding. It can bind to the receptor along with prolactin and still silence it.

I think the competitive antagonists are likely better than nothing, but they won't give the kind of regrowth the antibody does

Per the BAY patent:

competitive PRLR antagonists are not effective in neutralizing local PRL signaling in the hair follicle due to their negative characteristics which are

1) a reduced PRLR inhibition in the presence of increasing PRL concentrations due to the competitive mechanism of action
2) reduced half-life
3) reduced affinity to the PRLR if compared to PRL.

SMI has already solved no 2. It also has very strong affinity to the PRL receptor. Kd= 3.3. It remains to be seen if it is enough to solve 1, and 3.

 

[FollicleGuardian]

SMI is for breast cancer, and in breast cancer tissues iirc the PRL concentration is 17.6x normal tissues. So it should in theory be very potent. If not it will never work for breast cancer. And consequenses much worse than balding ofc.

 

[czecha]

SMI is for breast cancer, and in breast cancer tissues iirc the PRL concentration is 17.6x normal tissues. So it should in theory be very potent. If not it will never work for breast cancer. And consequenses much worse than balding ofc.

Cope

 

[Gegen]

Cope

sh*t he continues to spread czechamaxxing here

 

[FollicleGuardian]

Cope

I miss you bro

 

[RolfLeeBuckler]

We Need an Update of HopeMedicine as soon as possible.
They Stated in decembre 2020 that they will Start Phase II trial in 2021

... so please give us signs of life -HopeMedicine

 

[Will Be an Egg in 5 years]

Starting to lose hope on this one

 

[pegasus2]

Starting to lose hope on this one

Never lose hope. We just started experimenting with this in moderate doses this last week.

 

[trialAcc]

Starting to lose hope on this one

Losing hope on a treatment that was in phase 1 when you heard about it and still in phase 1 now?

 

[FatCat]

And will stay forever in phase 1 Lol! Baldies hopes vanished

Who sh*t in your cereal?

 

[trialAcc]

Who sh*t in your cereal?

Judging by the fact that's he's commented on almost every thread in the forum, probably life on a repetitive basis.

 

[Redgate]

What’s life like being bald everyday? I’m suprised you haven’t killed yourself LOL

have sex incel

 

[pegasus2]

Heino got banned again lol

 

[czecha]

love react this comment boyos

 

[Dimitri001]

We Need an Update of HopeMedicine as soon as possible.
They Stated in decembre 2020 that they will Start Phase II trial in 2021

... so please give us signs of life -HopeMedicine

You're saying they need to give us some hope?

 

[poopfeast420]

https://www.asiaone.com/business/ho...nancing-strengthening-capabilities-global?amp

Tl;dr: Hopemed closes $56mm series B round. Will be used to fund HMI-115 phase 2 alopecia studies for US/CN/EU, which will start "soon" (2021 for sure it seems). Again confirmed successful HMI-115 phase 1 in humans.

Ok, between this and Kintor the Chinese are officially not here to f*** around. If they start and finish phase 2 in 2021 and immediately go to phase 3, could we see this drug released in early 2023?

 

[FollicleGuardian]

https://www.asiaone.com/business/ho...nancing-strengthening-capabilities-global?amp

Tl;dr: Hopemed closes $56mm series B round. Will be used to fund HMI-115 phase 2 alopecia studies for US/CN/EU, which will start "soon" (2021 for sure it seems). Again confirmed successful HMI-115 phase 1 in humans.

Ok, between this and Kintor the Chinese are officially not here to f*** around. If they start and finish phase 2 in 2021 and immediately go to phase 3, could we see this drug released in early 2023?

Amazing find bro!

 

[Gegen]

https://www.asiaone.com/business/ho...nancing-strengthening-capabilities-global?amp

Tl;dr: Hopemed closes $56mm series B round. Will be used to fund HMI-115 phase 2 alopecia studies for US/CN/EU, which will start "soon" (2021 for sure it seems). Again confirmed successful HMI-115 phase 1 in humans.

Ok, between this and Kintor the Chinese are officially not here to f*** around. If they start and finish phase 2 in 2021 and immediately go to phase 3, could we see this drug released in early 2023?

Here's my dopamine rush

 

[trialAcc]

https://www.asiaone.com/business/ho...nancing-strengthening-capabilities-global?amp

Tl;dr: Hopemed closes $56mm series B round. Will be used to fund HMI-115 phase 2 alopecia studies for US/CN/EU, which will start "soon" (2021 for sure it seems). Again confirmed successful HMI-115 phase 1 in humans.

Ok, between this and Kintor the Chinese are officially not here to f*** around. If they start and finish phase 2 in 2021 and immediately go to phase 3, could we see this drug released in early 2023?

That's actually a large series-B for a company who's primary indication is hairloss. These guys are not playing around and there must be some serious hype on this antibody behind the scenes.

Seriously, can anyone name a larger funding round for a leading hairloss compound? Most companies are kicking scraps of funding in the single millions if lucky.

 

[pegasus2]

https://www.asiaone.com/business/ho...nancing-strengthening-capabilities-global?amp

Tl;dr: Hopemed closes $56mm series B round. Will be used to fund HMI-115 phase 2 alopecia studies for US/CN/EU, which will start "soon" (2021 for sure it seems). Again confirmed successful HMI-115 phase 1 in humans.

Ok, between this and Kintor the Chinese are officially not here to f*** around. If they start and finish phase 2 in 2021 and immediately go to phase 3, could we see this drug released in early 2023?

Awesome. Wish we knew what soon was.