Baldness cure may be coming after discovery of protein that fuels hair growth

[OtyMac]

Baldness cure on horizon? Harvard scientists discover protein that fuels hair growth

The potentially groundbreaking baldness cure could lead to a cream that fuels an unlimited supply of locks for the follicly-challenged.

www.studyfinds.org

 

[scientist_0005]

if i was a research scientist in dermatology i would be f*****g emberassed for myself and all of my collegues that so little progress has been made in 30 years. plus i think those article writers with their bs pop science articles should be punched in the face

 

[Roeysdomi]

Baldness cure on horizon? Harvard scientists discover protein that fuels hair growth

The potentially groundbreaking baldness cure could lead to a cream that fuels an unlimited supply of locks for the follicly-challenged.

www.studyfinds.org

Every time i see article thats says that stress cuz balding or there is natural way to treat i want to punch the author.
This genetic condition is super complex.
The best way to win against it is having good genes. Lol.

 

[scientist_0005]

Every time i see article thats says that stress cuz balding or there is natural way to treat i want to punch the author.
This genetic condition is super complex.
The best way to win against it is having good genes. Lol.

life is all about genes. not to sound like an incel but uve grown increasingly bitter and i came to realize that everyone who denies the utter devastating importance of genetics in your life is full of cow sh*t

 

[hairlossisevil]

1. it's a study on rodents
2. primary glucocorticoid in humans is cortisol not corticosterone
3. trigger or 'stressor' in Androgenetic Alopecia are androgens

 

[Kev123]

if i was a research scientist in dermatology i would be f*****g emberassed for myself and all of my collegues that so little progress has been made in 30 years. plus i think those article writers with their bs pop science articles should be punched in the face

Dermatologists usually know nothing about hair loss, unless they specialize in it specifically, and make a career out of it. And that is a small amount of med school students who pursue research on hairloss.

I remember the moment I realized dermatologists don’t care about male pattern baldness. From my experience, they are largely clueless about male pattern baldness. I made several visits/follow-ups for a skin condition, in a highly regarded research university. This school is always top 3 overall on usnews, top 5 university in medical research:

None of the dermatologists knew what minoxidil and finasteride was. I had to use the brand names, Rogaine and Propecia, and that happened to ring a bell. They did not know the drug names of treatments that have been around since the 90s. That should tell you everything right there: hair loss is largely ignored by the medical field.

In another dermatology clinic, a fancy/expensive one, the dermatologists there had no idea about the derma roll/dermapen studies for hair loss. I’ve since had no more visits to dermatologists and just read forums for help (like hair loss talk).

I know this may sound crazy because a dermatologist has 12 years of higher education including 8 years for med school and residency: the truth is some random Jon Doe off the streets like me or you, who reads up on hairloss news, science, and research, will likely have more knowledge about hair loss than a general derm. This is my 12th year as a member of hair loss talk. No med school needed. No $250k med school debt. And I pretty much taught those derms what is the drug name of Rogaine and Propecia. 22 year old me (at the time). And it’s not their age or outdated knowledge, there were young derms and old derms interacting with me. None of them knew much about male pattern baldness and their treatments.

So, dermatologists aren’t/can’t be embarrassed about something they don’t even know exists.

 

[Roeysdomi]

Stress does cause diffuse thinning, you mongrel ape. If you've ever felt actual stress you'd know, try taking a swing at ME you punk my shoulders are broader than your whole height I'd slap your hairline all the way back to Norwood12. Try losing a hand, try contemplating actually hurting someone. Yeah that causes stress enough to make your gut wrench and literally be sick for days from just stress. It fucks up your whole biology and cortisol halts hair growth. Every website says telogen efflevium is recoverable but it hardly ever is

There's plenty of diffuse among soldiers too if you've ever seen any in your life. Not the Norwood pattern just flat out thinning

I dont think they mean this level of stress…

 

[scientist_0005]

cellular stress

 

[Janks16]

Won't be coming anytime soon. But I hope I'm wrong.

 

[OtyMac]

keep dreaming lol!

I'm not going to defend this article to death because it WAS in mice. But, we do know that the HPA is overactive in Androgenetic Alopecia also. So...is it that far fetched to at least check into it further?

 

[pegasus2]

This has been posted like a dozen times. Never believe these clickbait headlines. This is for people without male pattern baldness. It's for the type of thinning that everyone gets as they get older, even in the occipital area. Targeting gas6 won't do anything to reverse make pattern baldness

 

[surfer9]

do u guys something could be out there that regrows hair that we don't know about... maybe something in your cupboard, maybe your wive's love juice..... something is right there that can regrow full head of hair on our heads if we applied it regularly.

 

[Micky_007]

Every time i see article thats says that stress cuz balding or there is natural way to treat i want to punch the author.
This genetic condition is super complex.
The best way to win against it is having good genes. Lol.

Which is exactly why I believe Gene Editing Therapy is going to be a true treatment or cure for Male Patterned Balding.

 

[scientist_0005]

Which is exactly why I believe Gene Editing Therapy is going to be a true treatment or cure for Male Patterned Balding.

only people that dont know what they are talking aboht talk aboutgene editing. there us hundreds kf potential routes a treatment could go and they wre all easier and more feasible than identifying target genes of male pattern baldness, figuring out how they differ from someone not affected and then tsrget them with crispr not just in the relevant tissue but surrounding tissue as well. also you are already born and your dna is set. sure you could vector something into every single DP affected but that is just crazy. and furthermore it is not necessary to treat male pattern baldness at all. you literally just have to find a way to locally inhibit expression of the androgen receptor. one could think this is jot hsrd but apparently it is harder than literally cloning the entire follicle.

 

[Micky_007]

only people that dont know what they are talking aboht talk aboutgene editing. there us hundreds kf potential routes a treatment could go and they wre all easier and more feasible than identifying target genes of male pattern baldness, figuring out how they differ from someone not affected and then tsrget them with crispr not just in the relevant tissue but surrounding tissue as well. also you are already born and your dna is set. sure you could vector something into every single DP affected but that is just crazy. and furthermore it is not necessary to treat male pattern baldness at all. you literally just have to find a way to locally inhibit expression of the androgen receptor. one could think this is jot hsrd but apparently it is harder than literally cloning the entire follicle.

Only people who think they know what they are talking about BUT actually DON'T KNOW what their talking about say things like you say.

FYI, you don't even need to know the exact Molecular signals to turn on and off to combat hairloss at its specific pathways.

They just need to return the cells in the scalp to a younger state, at which time the follicles were strong enough to combat hairloss.

Some of the richest people in the world, and the most successful businesses and people are working on this exact concept.

For example, Turn Biotechnologies is working on using this concept but in the hope to be a cure or amazing treatment for Hairloss.

David Sinclair, is also working to restore cells to a younger state and also is working on hair.

The 2nd richest man in the world Jeff Bezos, is working with another billionaire, Yuri Milner, to return cells to a younger state. Their company is called Atlos Labs.

Also, if you're concerned with off-targets you should really do your research before talking and find out just how much Gene Editing has advanced just this year alone.

They went from only having Cas-9, to CRISPRoff and CRISPRon.

In a paper published April 9, 2021, in the journal Cell, researchers at UC San Francisco and the Whitehead Institute describe a novel CRISPR-based tool called “CRISPRoff,” which allows scientists to switch off almost any gene in human cells without making a single edit to the genetic code. The researchers also show that once a gene is switched off, it remains inert in the cell’s descendants for hundreds of generations, unless it is switched back on with a complementary tool called CRISPRon, also described in the paper.

Because the epigenome plays a central role in many diseases, from viral infection to cancer, CRISPRoff technology may one day lead to powerful epigenetic therapies. And since this approach doesn’t involve any DNA edits, it’s likely to be safer than conventional CRISPR therapeutics, which have been known to cause unwanted and potentially harmful changes to the genome.

There's even Cas-12f or Cas14 and Cas-13

Theres also a lot more advancements.

I have no doubt that in the near future we will atleast see a very good Gene Based treatment for Hairloss.

 

[Will Be an Egg in 5 years]

Just more five years

 

[scientist_0005]

Only people who think they know what they are talking about BUT actually DON'T KNOW what their talking about say things like you say.

FYI, you don't even need to know the exact Molecular signals to turn on and off to combat hairloss at its specific pathways.

They just need to return the cells in the scalp to a younger state, at which time the follicles were strong enough to combat hairloss.

Some of the richest people in the world, and the most successful businesses and people are working on this exact concept.

For example, Turn Biotechnologies is working on using this concept but in the hope to be a cure or amazing treatment for Hairloss.

David Sinclair, is also working to restore cells to a younger state and also is working on hair.

The 2nd richest man in the world Jeff Bezos, is working with another billionaire, Yuri Milner, to return cells to a younger state. Their company is called Atlos Labs.

Also, if you're concerned with off-targets you should really do your research before talking and find out just how much Gene Editing has advanced just this year alone.

They went from only having Cas-9, to CRISPRoff and CRISPRon.

In a paper published April 9, 2021, in the journal Cell, researchers at UC San Francisco and the Whitehead Institute describe a novel CRISPR-based tool called “CRISPRoff,” which allows scientists to switch off almost any gene in human cells without making a single edit to the genetic code. The researchers also show that once a gene is switched off, it remains inert in the cell’s descendants for hundreds of generations, unless it is switched back on with a complementary tool called CRISPRon, also described in the paper.

Because the epigenome plays a central role in many diseases, from viral infection to cancer, CRISPRoff technology may one day lead to powerful epigenetic therapies. And since this approach doesn’t involve any DNA edits, it’s likely to be safer than conventional CRISPR therapeutics, which have been known to cause unwanted and potentially harmful changes to the genome.

There's even Cas-12f or Cas14 and Cas-13

Theres also a lot more advancements.

I have no doubt that in the near future we will atleast see a very good Gene Based treatment for Hairloss.

you sound like someone who follows bob sinclair for sure, slmeone who is an over promiser like nobody has eved seen before, he says they are working on all these things which is good and well but what progress does he have to show for? i know what i am talking about. there is a lot of hype in anti aging medicine and "in 10 years we will be immortal anxway" ws all heard it and the hair loss cure has been here in 2008 as well! you say you "only need to revert the cells to a xounger state" how do you do thaz without identifying the necesarry pathways, you say this as if kt would be the simplest thing in the world. just because we can do this is worms and fruit flies does not mean we can translate it to humans, much like mice are cured when it comes to hair loss. how exactly do yoh use crispr to turn of the andeogen receptor gene only in the DP cells? how do you vector it in and assure that it staxs nuked when the cells get renewed? we dont even know how the DP regenerates. you think hair cloning is 10 years away, this is twice as long away i bet.

epiginetic therapies will be the future for sure but this is a long time away with crispron or off, we have already epiginetic therapies like Olix irna therapy but these are drugs that you will have to apply once in a while. its also not gene therapy

 

[scientist_0005]

actually crisproff thinking about it is what we need. just strongly methylate the androgen receptor and you are done, question is how do you do that in only the target cells? it would be like kintors degrader just more potent and only once application

 

[trialAcc]

Dermatologists usually know nothing about hair loss, unless they specialize in it specifically, and make a career out of it. And that is a small amount of med school students who pursue research on hairloss.

I remember the moment I realized dermatologists don’t care about male pattern baldness. From my experience, they are largely clueless about male pattern baldness. I made several visits/follow-ups for a skin condition, in a highly regarded research university. This school is always top 3 overall on usnews, top 5 university in medical research:

None of the dermatologists knew what minoxidil and finasteride was. I had to use the brand names, Rogaine and Propecia, and that happened to ring a bell. They did not know the drug names of treatments that have been around since the 90s. That should tell you everything right there: hair loss is largely ignored by the medical field.

In another dermatology clinic, a fancy/expensive one, the dermatologists there had no idea about the derma roll/dermapen studies for hair loss. I’ve since had no more visits to dermatologists and just read forums for help (like hair loss talk).

I know this may sound crazy because a dermatologist has 12 years of higher education including 8 years for med school and residency: the truth is some random Jon Doe off the streets like me or you, who reads up on hairloss news, science, and research, will likely have more knowledge about hair loss than a general derm. This is my 12th year as a member of hair loss talk. No med school needed. No $250k med school debt. And I pretty much taught those derms what is the drug name of Rogaine and Propecia. 22 year old me (at the time). And it’s not their age or outdated knowledge, there were young derms and old derms interacting with me. None of them knew much about male pattern baldness and their treatments.

So, dermatologists aren’t/can’t be embarrassed about something they don’t even know exists.

This is the case for almost any condition, it doesn't mean that conditions are ignored. If you have any chronic illness outside of the basic 2-5 common ones, I guarantee you know more about it yourself then your GP does. Specialists are called that for a reason.

Baldness is only largely ignored because it's considered cosmetic, just as any other cosmetic condition including severe acne is largely ignored. Most GPs would prescribe you benzol peroxide for acne and destroy your skin, or send you to a specialist for Accutane. None of them would dive into the hormonals of why you have acne.

 

[Kev123]

This is the case for almost any condition, it doesn't mean that conditions are ignored. If you have any chronic illness outside of the basic 2-5 common ones, I guarantee you know more about it yourself then your GP does. Specialists are called that for a reason.

Baldness is only largely ignored because it's considered cosmetic, just as any other cosmetic condition including severe acne is largely ignored. Most GPs would prescribe you benzol peroxide for acne and destroy your skin, or send you to a specialist for Accutane. None of them would dive into the hormonals of why you have acne.

What ever the case may be, dermatologists don’t care about hair loss. That was my point, the label of “cosmetics” goes to show how low of a priority it is. No one cares about us baldies. We are subhuman. Psychological and social issues that male pattern baldness gives us is not enough for them.

Hair loss would need to be discovered as a link to a life threatening disease in order for it to gain attention.