Baldies have 3X scalp DHT, and more androgen receptors

[michael barry]

....."Both women and men with androgenetic alopecia have higher levels of androgen receptors and 5-reductase type 1 and 2 in frontal than in occipital hair follicles, whereas higher levels of aromatase were found in their occipital follicles (Sawaya and Price, 1997). Aromatase content in women's frontal hair follicles was six times greater than in frontal hair follicles in men. Frontal hair follicles in women had 3 and 3.5 times less 5-reductase type 1 and 2, respectively, than frontal hair follicles in men (Sawaya and Price, 1997)."


That is from this, http://www.nature.com/jid/journal/v119/ ... 1659a.html
article from the Journal of Investigative Dermatology. Its in the paragraph labelled "[ANDROGENIC ALOPECIA]"



Pretty much says it all doesn't it guys?



Its not shampoo, its not short haircuts, its not big pillows, its not "tension", its not edema, its not combs, its not lack of this or that. Its too much DHT, and too many androgen receptor sites on the follicles. Period.

 

[Balding_1]

With what we have available (propecia, avodart, revivogen, nizoral etc.) it seems like baldness should be easily reversible if caught early. I just wonder why this isn't always the case if it all comes down to just too much DHT.

 

[I_Hate_DHT]

Good article...

Now, if Propecia blocks 80% of DHT... How is that 80% measured?

Does it block 80% in two individuals with different DHT levels? I always wonder how much DHT does Merck consider as 80%..

Not sure if my question is clear... :?

 

[soulsurvivor316]

With what we have available (propecia, avodart, revivogen, nizoral etc.) it seems like baldness should be easily reversible if caught early. I just wonder why this isn't always the case if it all comes down to just too much DHT.

Hair loss wasn't even reversed in the castrates. As Bryan has stated before, once male pattern baldness has set in, certain processes take hold that are not entirely androgen dependent. So propecia, avodart, etc. will never be able to fully reverse baldness.

For many people, a drug like avodart will significantly slow down their hair loss to the point that it seems as though baldness has ceased to progress. They may stay around baseline for decades. Thats good enough for me.

 

[hair today gone tomorrow]

Good article...

Now, if Propecia blocks 80% of DHT... How is that 80% measured?

Does it block 80% in two individuals with different DHT levels? I always wonder how much DHT does Merck consider as 80%..

Not sure if my question is clear... :?

it would be 80% of *your* dht....whatever your baseline level was.

 

[CCS]

is it 3x? I thought it was 2x. The standard deviation is large on that, just so you know.

 

[Newbaldy84]

I really believe that combo of dutasteride and strong antiandrogen wil halt baldness permanently. Now the regrowth that's a diffrent story

 

[CCS]

Good article...

Now, if Propecia blocks 80% of DHT... How is that 80% measured?

Does it block 80% in two individuals with different DHT levels? I always wonder how much DHT does Merck consider as 80%..

Not sure if my question is clear... :?

those are averages, and difficult to measure. Often calculated from other stuff.

 

[tomas99]

Yeah, it seems that inflammation occurs, also oxidative stress takes part when male pattern baldness is already set up, so it is necessary to fight it from all possible angles.

 

[dresden]

how do you fight that oxidative stress?

 

[tomas99]

Antioxidants and anything that contains super oxide dismutase (SOD, like e.g. GliSODin).

Tricomin contains SOD thats why I think it could have some results after you stop using it, it could slow down or little bit reverse balding process.

 

[Nick4441]

There's got to be more to it than just DHT causing hairloss otherwise nearly all of us would have stopped our hairloss and that's not the case...

Every hair I lose i'm convinced no new one is coming up behind to replace it...its all dying I'm trying to be realistic and put some more faith in in dutasteride now i've moved to that as finasteride was doing nothing, but something tells me i've had it and HM will be the only thing left in the end when it comes out.

Global's blood tests in his post on here showed how much dutasteride was reducing DHT and it was 50% below the lowest DHT figure for a male. If he was in the expect average then 70-90% reduction was being achieved.

 

[abcdefg]

Yeah. Its not just dht its the stupid receptors and sensitivity to androgens. If we could completely destroy or stop the receptors from even binding to dht that should completely halt hairloss if caught early enough.

 

[squeegee]

:wow:

 

[abcdefg]

I think this researcher Marty E Sawaya aka Mary Sawaya often cited for some of these androgen receptor studies was debarred for fraud by the FDA so I dont know how much stock we should be putting into this she never even had a medical license to work on these she just photocopied one she took. It really sounds like she is the same person mentioned in these fraud articles which makes you wonder why her work is still out there being cited all over the place without mention of it.

http://www.nature.com/jid/journal/v109/n3/abs/5610071a.html
"Marty E Sawaya[SUP]1[/SUP] and Vera H Price"

FDA debars
https://docs.google.com/viewer?a=v&...gJeiZZ&sig=AHIEtbQQVIRs4ioHMwjl5rFFH2oBgnh_og

http://www.centerwatch.com/news-onl...vestigators-six-years-after-fraud-convictions

"Sawaya pleaded guilty to charges that she created a medical license by obtaining a copy of a colleague's Florida medical license and altering that license using a photocopy machine to reflect that the license was issued in her name. She then submitted the fraudulent Florida medical license to the sponsor of a clinical trial, for which she was a clinical investigator. "

 

[squeegee]

hahaahah Awesome abcdefg!

 

[Armando Jose]

without words ....

 

[abcdefg]

The problem is without her studies how much real research is really out there on androgen receptors? It seems like an area that is important and could use some looking at. She was a part of a lot of research and her fraud happened a long time ago.
Someone else on the forum found this out I just went back and dug it back up since people seem to forget easily or just never knew.

 

[Armando Jose]

I am with you abcdefg, how much real research is really out?