More talk of nrf2 as mentioned in the above paper:
Reactive oxygen species (ROS) have long been known as one of the major factors contributing to premature aging. They cause the oxidation of cellular molecules, leading to DNA damage and impairing the function of cellular proteins. Eventually, this reduces cell viability and survival and in...
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Reactive oxygen species (ROS) have long been known as one of the major factors contributing to premature aging. They cause the oxidation of cellular molecules, leading to DNA damage and impairing the function of cellular proteins. Eventually, this reduces cell viability and survival and in particular in hair follicles, this causes a shortening of the anagen growth phase and ultimately leads to hair loss. Mibelle Biochemistry has developed SantEnergy™ to energize hair follicle cells and protect them from the harmful impacts of ROS.
Besides the skin, also the hair and scalp are exposed to a range of harmful factors daily. Many of these cause the formation of
reactive oxygen species (ROS), which further damage cellular proteins and lipids, but also cause oxidative DNA damage in the sensitive hair follicle cells. The hair follicles possess a defense system in order to remove ROS and protect the cells from protein and lipid oxidation as well as oxidative DNA damage.
The master regulator of the oxidative stress response, Nuclear factor erythroid 2-related factor (Nrf2), functions as a switch to activate the synthesis of antioxidant enzymes and to replenish the pool of cellular antioxidants such as glutathione. In the scalp in particular, Nrf2 was shown to be activated upon stress and to decrease ROS levels and prevent lipid peroxidation. Thereby, Nrf2 activation reduces the premature progression to the catagen growth regression phase and ultimately ameliorates hair growth inhibition caused by oxidative stress. However, this cellular self-protection system is unable to cope with an excess detrimental chemical species and its activity was shown to decline with age.
To support the cellular self-protection system, prevent UV-induced oxidative damage and energize the hair follicles,
Mibelle Biochemistry has developed SantEnergy™ based on a polyphenol-rich extract from the wild harvested aerial parts of Eriodictyon californicum, a plant also known as Yerba Santa, holy herb or mountain balm. The leaves of this plant have traditionally been used to treat upper respiratory infections and asthma and it has numerous recorded health benefits including antioxidant, anti-inflammatory, anti-bacterial and neuroprotective effects.
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