Applying Zix give headaches after 20mins..

ceeprm2

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Hi I was inspired to give Zix another go after reading Worms megathread- I used to use it years ago and not sure it did much (possibly slowed hairloss down) but it does seem to cut down on scalp inflamation and itch if nothing else.
I initially just made a a batch with 200mg zinc sulphate (crushed healthaid brand) and 150mg P5p (pure encapsulations brand) and 60ml of distilled water- this is Joes (zix creator) original receipe.
Every time I use it I seem to get this dull headache after about 20mins which lasts for a couple of hours- do many other folks experience this? I guess the solution is to stop using it but was anyone who experienced this managed to tweek the formula in any way to mitigate headaches?

I have also experimented with LLLT and microneedling- so my guess is that my scalp is much more porous now and the tiny bit of zix im applying (1-2ml) is possibly absorbing too much?

I found it strange as this is always touted as the side effect free hairloss treatment.

cheers

Phil
 

Esquire Janey

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Zix doesn't work so I recommend that you stop taking it in order to avoid headaches. Try polysorbate 80, strong dandruff shampoo or Keto to minimize inflammation while dissolving rancid, infected sebum from scalp and face.
 

RXShopMD_Team

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A few observations on the homemade zinc solution and the headaches (RXShop.md pharmacy editorial team, general information only):
  • Evidence: zinc and vitamin B6 (P5P) can inhibit 5-alpha reductase in lab studies, but there are no good clinical trials showing a topical zinc mix regrows hair. A soothing effect on scalp inflammation is plausible, similar to zinc pyrithione shampoos.
  • Headaches within 20 minutes after applying something to the scalp are not typical of zinc absorption at these amounts. Possible reasons include irritation and scalp tension, a reaction to the solution's acidity, or a coincidence. The simplest test is to stop it and see whether the headaches stop.
  • Homemade solutions made from crushed tablets contain fillers and are not sterile; they can grow bacteria if stored for days.
  • Easier alternatives for inflammation and itch: zinc pyrithione or ketoconazole 2% shampoo a few times a week, which have good evidence for seborrheic dermatitis.
If headaches persist after stopping, or come with neck stiffness, fever or vision changes, see a doctor.
 
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