You just have to open, not crush, the capsules. I'd go with less. One 500mg apple poly and maybe 1-200 mg of GSE. The problem is if you use too much, some of the mixoxidil might precipitate. I'm not sure which is less soluble, but minoxidil is almost saturated, which means if you add more minoxidil powder, it won't dissolve. I also don't know how much apple poly will dissolve in ethanol, since it is water soluble. PG can dissolve almost anything. I make a separate vehicle for my apple poly, and do add a little GSE in with the minoxidil.