We have changed our Proxiphen vehicle recently. The main reason for the change now is because our old vehicle is no longer available.
Knowing well ahead of time we were going to need to make the change, we carefully considered a number of vehicles before settling on the present one. In addition to a little better appearance and "feel", it seems to solubolize our active ingredients a little better. So, there does not seem to be as much precipitation out during storage and shipping (which is what causes the graininess).
However, in line with our policy of sacrificing cosmetic considerations to efficacy, we will probably just add more active ingredients and/or mess with the forumlation so we get a bit of precipitation. Reason is that skin penetration of drugs is better when they are at or exceed their limit of solubility. Probably not a big effect, but every bit helps.
Peter H. Proctor, PhD,MD