Androgenic alopecia associations.

[docj077]

A smaller study, but it is informative nonetheless. Especially, for those that like to associate male pattern baldness with EVERYTHING.



Eur J Dermatol. 2007 May-Jun;17(3):220-2. Epub 2007 May 4. Links
Association of androgenetic alopecia and hypertension.Ahouansou S, Le Toumelin P, Crickx B, Descamps V.
Department of Public Health, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny Cedex. France.

Androgenetic alopecia is considered to be associated with coronary heart disease but the explanation of this association remains unknown. Hypertension is highly prevalent in patients with coronary heart disease. Essential hypertension is linked to hyperaldosteronism and spironolactone, an antihypertensive drug which is a mineralocorticoid receptor antagonist, has been used for a long time in the treatment of androgenic alopecia. We recently observed in a double transgenic mouse model that overexpression of a mineralocorticoid receptor targeted to the skin induced the development of alopecia.We prospectively studied the association of hypertension and androgenetic alopecia in Caucasian men. Two hundred and fifty Caucasian men aged 35-65 years were consecutively recruited by 5 general practitioners (50 per practitioner). Data collected included age, androgenetic alopecia score with a simplified Norwood's score (0-4), blood pressure or history of hypertension, smoking, history of diabetes mellitus or hyperlipidemia, familial history of androgenetic alopecia, and treatment. Chi-square, Fisher exact tests and linear regression model were used for statistical analysis.Hypertension was strongly associated to androgenetic alopecia (p < 0.001). Linear regression tests confirmed that this association was independent of age : odds ratio was 2.195 (95% CI : 1.1-4.3). Familial history of androgenetic alopecia was also strongly associated with androgenetic alopecia : odds ratio was 10.870 (95% CI : 4.3-27.1). Other variables (diabetes mellitus, hyperlipidemia, smoking, treatment) were not associated with androgenetic alopecia.We were limited by a relatively small study sample but in this study androgenetic alopecia was strongly associated with hypertension. Association of androgenetic alopecia and hyperaldosteronism warrants additional studies. The use of specific mineralocorticoid receptor antagonists could be of interest in the treatment of androgenetic alopecia.

 

[IBM]

another reason to take small dose of spironolactone everyday. How about that!

 

[S Foote.]

A smaller study, but it is informative nonetheless. Especially, for those that like to associate male pattern baldness with EVERYTHING.



Eur J Dermatol. 2007 May-Jun;17(3):220-2. Epub 2007 May 4. Links
Association of androgenetic alopecia and hypertension.Ahouansou S, Le Toumelin P, Crickx B, Descamps V.
Department of Public Health, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny Cedex. France.

Androgenetic alopecia is considered to be associated with coronary heart disease but the explanation of this association remains unknown. Hypertension is highly prevalent in patients with coronary heart disease. Essential hypertension is linked to hyperaldosteronism and spironolactone, an antihypertensive drug which is a mineralocorticoid receptor antagonist, has been used for a long time in the treatment of androgenic alopecia. We recently observed in a double transgenic mouse model that overexpression of a mineralocorticoid receptor targeted to the skin induced the development of alopecia.We prospectively studied the association of hypertension and androgenetic alopecia in Caucasian men. Two hundred and fifty Caucasian men aged 35-65 years were consecutively recruited by 5 general practitioners (50 per practitioner). Data collected included age, androgenetic alopecia score with a simplified Norwood's score (0-4), blood pressure or history of hypertension, smoking, history of diabetes mellitus or hyperlipidemia, familial history of androgenetic alopecia, and treatment. Chi-square, Fisher exact tests and linear regression model were used for statistical analysis.Hypertension was strongly associated to androgenetic alopecia (p < 0.001). Linear regression tests confirmed that this association was independent of age : odds ratio was 2.195 (95% CI : 1.1-4.3). Familial history of androgenetic alopecia was also strongly associated with androgenetic alopecia : odds ratio was 10.870 (95% CI : 4.3-27.1). Other variables (diabetes mellitus, hyperlipidemia, smoking, treatment) were not associated with androgenetic alopecia.We were limited by a relatively small study sample but in this study androgenetic alopecia was strongly associated with hypertension. Association of androgenetic alopecia and hyperaldosteronism warrants additional studies. The use of specific mineralocorticoid receptor antagonists could be of interest in the treatment of androgenetic alopecia.

And your take on this statement: "androgenetic alopecia was strongly associated with hypertension. Is????

S Foote.

 

[michael barry]

Salt sensitivity
Sodium is the environmental factor that has received the greatest attention. It is to be noted that approximately 60% of the essential hypertension population is responsive to sodium intake[citation needed]. This is due to the fact that increasing amounts of salt in a person's bloodstream causes the body to draw more water, increasing the pressure on the blood vessel walls.


[edit] Role of renin
Renin is a hormone secreted by the juxtaglomerular cells of the kidney and linked with aldosterone in a negative feedback loop. The range of renin activity observed in hypertensive subjects tends to be broader than in normotensive individuals. In consequence, some hypertensive patients have been defined as having low-renin and others as having essential hypertension. Low-renin hypertension is more common in African Americans than Caucasians and may explain why they tend to respond better to diuretic therapy than drugs that interfere with the renin-angiotensin system.

High Renin levels predispose to Hypertension: Increased Renin --> Increased Angiotensin II --> Increased Vasoconstriction, Thirst/ADH and Aldosterone --> Increased Sodium Reabsorption in the Kidneys (DCT and CD) --> Increased Blood Pressure.


[edit] Insulin resistance
Insulin is a polypeptide hormone secreted by the pancreas. Its main purpose is to regulate the levels of glucose in the body antagonistically with glucagon through negative feedback loops. Insulin also exhibits vasodilatory properties. In normotensive individuals, insulin may stimulate sympathetic activity without elevating mean arterial pressure. However, in more extreme conditions such as that of the metabolic syndrome, the increased sympathetic neural activity may over-ride the vasodilatory effects of insulin. Insulin resistance and/or hyperinsulinemia have been suggested as being responsible for the increased arterial pressure in some patients with hypertension. This feature is now widely recognized as part of syndrome X, or the metabolic syndrome

 

[wookster]

:salut: ensativo: :salut:

http://www.eurekalert.org/pub_releases/ ... 090806.php

OHSU lab links gene to aged skin problems, cancer

[...]

"In humans, scientists and medical doctors documented the aging skin phenotype a long time ago, and the Smad7 over-expression in aged skin was reported a few years ago, but nobody knew whether these two events had any link," said Wang, who also serves in the OHSU departments of Cell and Developmental Biology, and Dermatology. "We found the mechanism that links these two together."

For their study, the researchers created genetically engineered mice in which Smad7 is expressed in the skin, including epidermal stem cells, with the expression level comparable to aged skin. They found that Smad7 over-expression shifts the epidermal stem cell differentiation program from forming hair follicles to sebaceous glands, causing the mice to exhibit balding and oily skin.

Surprising to the researchers was that, independent of its normal role in blocking signaling from a group of genes called Smad, Smad7 shuts down signaling of another group of genes called Wnt, by binding to a Wnt signaling protein known as Beta-catenin and degrading it with an enzyme called Smurf2. Wnt signaling is critical for organ development, but if Wnt signaling is too active, it also causes cancer.

"Our study identifies a new Beta-catenin degradation pathway," the scientists said in the study. "This finding has a significant impact not only on skin development and diseases, but also on diseases and cancers in other organs."

For example, enhanced Beta-catenin signaling contributes to many cancer types, including those of the colon, lung and brain. The researchers believe inducing over-expression of Smad7 or delivery of Smad7 directly to tumor cells would provide a therapeutic approach because of the boost in Beta-catenin degradation.

However, impaired Beta-catenin signaling contributes to neurodegeneration, such as that caused by Alzheimer's disease, retina degeneration, bone density defect and aging. For these diseases, blocking Smad7-mediated Beta-catenin degradation may offer a therapeutic approach.

I wonder if smad7 overexpression and impaired beta-catenin sigaling might also contribute to hypertension?

 

[docj077]

A smaller study, but it is informative nonetheless. Especially, for those that like to associate male pattern baldness with EVERYTHING.



Eur J Dermatol. 2007 May-Jun;17(3):220-2. Epub 2007 May 4. Links
Association of androgenetic alopecia and hypertension.Ahouansou S, Le Toumelin P, Crickx B, Descamps V.
Department of Public Health, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny Cedex. France.

Androgenetic alopecia is considered to be associated with coronary heart disease but the explanation of this association remains unknown. Hypertension is highly prevalent in patients with coronary heart disease. Essential hypertension is linked to hyperaldosteronism and spironolactone, an antihypertensive drug which is a mineralocorticoid receptor antagonist, has been used for a long time in the treatment of androgenic alopecia. We recently observed in a double transgenic mouse model that overexpression of a mineralocorticoid receptor targeted to the skin induced the development of alopecia.We prospectively studied the association of hypertension and androgenetic alopecia in Caucasian men. Two hundred and fifty Caucasian men aged 35-65 years were consecutively recruited by 5 general practitioners (50 per practitioner). Data collected included age, androgenetic alopecia score with a simplified Norwood's score (0-4), blood pressure or history of hypertension, smoking, history of diabetes mellitus or hyperlipidemia, familial history of androgenetic alopecia, and treatment. Chi-square, Fisher exact tests and linear regression model were used for statistical analysis.Hypertension was strongly associated to androgenetic alopecia (p < 0.001). Linear regression tests confirmed that this association was independent of age : odds ratio was 2.195 (95% CI : 1.1-4.3). Familial history of androgenetic alopecia was also strongly associated with androgenetic alopecia : odds ratio was 10.870 (95% CI : 4.3-27.1). Other variables (diabetes mellitus, hyperlipidemia, smoking, treatment) were not associated with androgenetic alopecia.We were limited by a relatively small study sample but in this study androgenetic alopecia was strongly associated with hypertension. Association of androgenetic alopecia and hyperaldosteronism warrants additional studies. The use of specific mineralocorticoid receptor antagonists could be of interest in the treatment of androgenetic alopecia.

And your take on this statement: "androgenetic alopecia was strongly associated with hypertension. Is????

S Foote.

"We recently observed in a double transgenic mouse model that overexpression of a mineralocorticoid receptor targeted to the skin induced the development of alopecia."

Your question was very vague. Be more specific when you ask questions.

Many different receptor subtypes can eventually affect the transcription of other molecular similar nuclear receptors like the androgen receptor.

 

[S Foote.]

A smaller study, but it is informative nonetheless. Especially, for those that like to associate male pattern baldness with EVERYTHING.



Eur J Dermatol. 2007 May-Jun;17(3):220-2. Epub 2007 May 4. Links
Association of androgenetic alopecia and hypertension.Ahouansou S, Le Toumelin P, Crickx B, Descamps V.
Department of Public Health, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny Cedex. France.

Androgenetic alopecia is considered to be associated with coronary heart disease but the explanation of this association remains unknown. Hypertension is highly prevalent in patients with coronary heart disease. Essential hypertension is linked to hyperaldosteronism and spironolactone, an antihypertensive drug which is a mineralocorticoid receptor antagonist, has been used for a long time in the treatment of androgenic alopecia. We recently observed in a double transgenic mouse model that overexpression of a mineralocorticoid receptor targeted to the skin induced the development of alopecia.We prospectively studied the association of hypertension and androgenetic alopecia in Caucasian men. Two hundred and fifty Caucasian men aged 35-65 years were consecutively recruited by 5 general practitioners (50 per practitioner). Data collected included age, androgenetic alopecia score with a simplified Norwood's score (0-4), blood pressure or history of hypertension, smoking, history of diabetes mellitus or hyperlipidemia, familial history of androgenetic alopecia, and treatment. Chi-square, Fisher exact tests and linear regression model were used for statistical analysis.Hypertension was strongly associated to androgenetic alopecia (p < 0.001). Linear regression tests confirmed that this association was independent of age : odds ratio was 2.195 (95% CI : 1.1-4.3). Familial history of androgenetic alopecia was also strongly associated with androgenetic alopecia : odds ratio was 10.870 (95% CI : 4.3-27.1). Other variables (diabetes mellitus, hyperlipidemia, smoking, treatment) were not associated with androgenetic alopecia.We were limited by a relatively small study sample but in this study androgenetic alopecia was strongly associated with hypertension. Association of androgenetic alopecia and hyperaldosteronism warrants additional studies. The use of specific mineralocorticoid receptor antagonists could be of interest in the treatment of androgenetic alopecia.

And your take on this statement: "androgenetic alopecia was strongly associated with hypertension. Is????

S Foote.

"We recently observed in a double transgenic mouse model that overexpression of a mineralocorticoid receptor targeted to the skin induced the development of alopecia."

Your question was very vague. Be more specific when you ask questions.

Many different receptor subtypes can eventually affect the transcription of other molecular similar nuclear receptors like the androgen receptor.

You have a bad habit of automaticaly jumping on the molecules, and not looking at the big picture.

The clear association here is higher blood pressure is linked with male pattern baldness, simple.

So what is the mechanism of this link?

S Foote.

 

[docj077]

[quote="S Foote.":7ec77]

A smaller study, but it is informative nonetheless. Especially, for those that like to associate male pattern baldness with EVERYTHING.



Eur J Dermatol. 2007 May-Jun;17(3):220-2. Epub 2007 May 4. Links
Association of androgenetic alopecia and hypertension.Ahouansou S, Le Toumelin P, Crickx B, Descamps V.
Department of Public Health, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny Cedex. France.

Androgenetic alopecia is considered to be associated with coronary heart disease but the explanation of this association remains unknown. Hypertension is highly prevalent in patients with coronary heart disease. Essential hypertension is linked to hyperaldosteronism and spironolactone, an antihypertensive drug which is a mineralocorticoid receptor antagonist, has been used for a long time in the treatment of androgenic alopecia. We recently observed in a double transgenic mouse model that overexpression of a mineralocorticoid receptor targeted to the skin induced the development of alopecia.We prospectively studied the association of hypertension and androgenetic alopecia in Caucasian men. Two hundred and fifty Caucasian men aged 35-65 years were consecutively recruited by 5 general practitioners (50 per practitioner). Data collected included age, androgenetic alopecia score with a simplified Norwood's score (0-4), blood pressure or history of hypertension, smoking, history of diabetes mellitus or hyperlipidemia, familial history of androgenetic alopecia, and treatment. Chi-square, Fisher exact tests and linear regression model were used for statistical analysis.Hypertension was strongly associated to androgenetic alopecia (p < 0.001). Linear regression tests confirmed that this association was independent of age : odds ratio was 2.195 (95% CI : 1.1-4.3). Familial history of androgenetic alopecia was also strongly associated with androgenetic alopecia : odds ratio was 10.870 (95% CI : 4.3-27.1). Other variables (diabetes mellitus, hyperlipidemia, smoking, treatment) were not associated with androgenetic alopecia.We were limited by a relatively small study sample but in this study androgenetic alopecia was strongly associated with hypertension. Association of androgenetic alopecia and hyperaldosteronism warrants additional studies. The use of specific mineralocorticoid receptor antagonists could be of interest in the treatment of androgenetic alopecia.

And your take on this statement: "androgenetic alopecia was strongly associated with hypertension. Is????

S Foote.

"We recently observed in a double transgenic mouse model that overexpression of a mineralocorticoid receptor targeted to the skin induced the development of alopecia."

Your question was very vague. Be more specific when you ask questions.

Many different receptor subtypes can eventually affect the transcription of other molecular similar nuclear receptors like the androgen receptor.

You have a bad habit of automaticaly jumping on the molecules, and not looking at the big picture.

The clear association here is higher blood pressure is linked with male pattern baldness, simple.

So what is the mechanism of this link?

S Foote.[/quote:7ec77]

And, you have a bad habit of oversimplifying that which is molecularly complex. They gave you the mechanism.

 

[S Foote.]

And, you have a bad habit of oversimplifying that which is molecularly complex. They gave you the mechanism.

And in a nutshell that is what?

S Foote.

 

[docj077]

And, you have a bad habit of oversimplifying that which is molecularly complex. They gave you the mechanism.

And in a nutshell that is what?

S Foote.

All nuclear receptors interact with the Wnt/Beta-catenin TCF signaling axis and with each other. Since you're such a master of molecular biology and biochemistry in general, I'm sure that you'll be able to figure out the rest.

 

[S Foote.]

And, you have a bad habit of oversimplifying that which is molecularly complex. They gave you the mechanism.

And in a nutshell that is what?

S Foote.

All nuclear receptors interact with the Wnt/Beta-catenin TCF signaling axis and with each other. Since you're such a master of molecular biology and biochemistry in general, I'm sure that you'll be able to figure out the rest.

And so the common factor in high blood pressure and male pattern baldness at the molecullar level is what??

Bearing in mind the "opposite effects" on hair growth?

I'll give you time to answer this, as i this is my last post for a few days.

S Foote.

 

[docj077]

[quote="S Foote.":e8dfe]

And, you have a bad habit of oversimplifying that which is molecularly complex. They gave you the mechanism.

And in a nutshell that is what?

S Foote.

All nuclear receptors interact with the Wnt/Beta-catenin TCF signaling axis and with each other. Since you're such a master of molecular biology and biochemistry in general, I'm sure that you'll be able to figure out the rest.

And so the common factor in high blood pressure and male pattern baldness at the molecullar level is what??

Bearing in mind the "opposite effects" on hair growth?

I'll give you time to answer this, as i this is my last post for a few days.

S Foote.[/quote:e8dfe]

If increased mineralicorticoid action and binding is associated with baldness and the receptor also happens to be a nuclear receptor, then I'm sure that you can figure out the rest just as I said. Hypertension is associated with an increase in aldosterone, which is a mineralicorticoid. The receptor is a nuclear receptor and can intefere or promote the action of other nuclear receptors. Just like progesterone receptors and estrogen receptors are known to effect the action of androgen receptors.

There doesn't have to be a common factor in order for their to be an association. High blood pressure is also associated with obesity, which just happens to be associated with insulin resistance. Insulin resistance is associated with baldness, as well. I could put puzzle pieces together all you want and I would still be scientifically correct with my assumptions.