As a guy who biased towards hardcore treatment, I did some cursory research on the subject of CYP17 inhibitors. Seems like Abiraterone acetate is a most potent representative of this class of medication. This drug was designed specifically for the treatment of castration-resistant prostate cancer and, currently, this is the only one CYP17A1-inhibitor which medical use was approved by FDA. I checked, it's extremely expensive: 1 250 mg pill costs more that $70. In one study patients with no response to ADT were required as much as 2000 mg of Abiraterone acetate a day and the duration of therapy was not less than 12 weeks. That's crazy!
Ketoconazole (for oral use) is another CYP17A1 inhibitor. Its antiandrogenic properties are very impressive too, but unfortunately, this drug wasn't approved by FDA due to high incidence rate of severe liver toxicity. It's stronger than cyproterone acetate, flutamide, bicalutamide and other commonly used antiandrogens.
Seviteronel (VT-464) seems to be a best option, cause apart from castration-resistant and breast cancers, it was directly intended for treatment of androgen dependent conditions such as precocious puberty, PCOS, congential adrenal hyperplasia. So, I suppose it should also be effective in the treatment of androgenic hair loss and seborrhea. It selectively inhibits CYP17 lyase, an enzyme necessary for the synthesis of androgen and estrogen and also directly blocks the androgen receptor, so it can be a better solution than spironolactone, cyproterone acetate, flutamide and bicalutamide. The good thing is that no serious cardiac issues or liver enzyme elevations have been observed when this drug was administered to the group of 100 patients. Preliminary results from a breast cancer trial are expected by the end of this month. I hope this drug will successfully replace cyproterone acetate as a most potent oral antiandrogen on the market. If it happens, I am seriously willing to try it, lol. Only sky-high price would be a biggest drawback for me...
What do you guys think about that?
Ketoconazole (for oral use) is another CYP17A1 inhibitor. Its antiandrogenic properties are very impressive too, but unfortunately, this drug wasn't approved by FDA due to high incidence rate of severe liver toxicity. It's stronger than cyproterone acetate, flutamide, bicalutamide and other commonly used antiandrogens.
Seviteronel (VT-464) seems to be a best option, cause apart from castration-resistant and breast cancers, it was directly intended for treatment of androgen dependent conditions such as precocious puberty, PCOS, congential adrenal hyperplasia. So, I suppose it should also be effective in the treatment of androgenic hair loss and seborrhea. It selectively inhibits CYP17 lyase, an enzyme necessary for the synthesis of androgen and estrogen and also directly blocks the androgen receptor, so it can be a better solution than spironolactone, cyproterone acetate, flutamide and bicalutamide. The good thing is that no serious cardiac issues or liver enzyme elevations have been observed when this drug was administered to the group of 100 patients. Preliminary results from a breast cancer trial are expected by the end of this month. I hope this drug will successfully replace cyproterone acetate as a most potent oral antiandrogen on the market. If it happens, I am seriously willing to try it, lol. Only sky-high price would be a biggest drawback for me...
What do you guys think about that?
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