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Androgen Actions On The Human Hair Follicle: Perspectives

Discussion in 'Hair Loss and Alopecia Published Studies' started by Squeegee 2.0, May 17, 2019.

  1. Squeegee 2.0

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    Abstract: Androgens stimulate beard growth but suppress hair growth in androgenetic alopecia (Androgenetic Alopecia). This condition is known as ‘androgen paradox’. Human pilosebaceous units possess enough enzymes to form the active androgens testosterone and dihydrotestosterone. In hair follicles, 5a-reductase type 1 and 2, androgen receptors (AR) and AR coactivators can regulate androgen sensitivity of dermal papillae (DP). To regulate hair growth, androgens stimulate production of IGF-1 as positive mediators from beard DP cells and of TGF-b1, TGF-b2, dickkopf1 and IL-6 as negative mediators from balding DP cells. In addition, androgens enhance inducible nitric oxide synthase from occipital DP cells and stem cell factor for positive regulation of hair growth in beard and negative regulation of balding DP cells. Moreover, Androgenetic Alopecia involves crosstalk between androgen and Wnt/b-catenin signalling. Finally, recent data on susceptibility genes have provided us with the impetus to investigate the molecular pathogenesis of Androgenetic Alopecia.

    https://onlinelibrary.wiley.com/doi/pdf/10.1111/exd.12024
     
    Kagaho and Armando Jose like this.

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