docj077
Senior Member
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I just found this interesting. What they've basically found is that the number of repeats you have in the androgen receptor gene directly influences your outcome on Finasteride. It's too bad that genetics and molecular biology haven't moved into a state of being more cost effective. Then, you could tell if this drug would work before you go and spend the hundreds of dollars needed to test out a years worth of treatment.
J Investig Dermatol Symp Proc. 2005 Dec;10(3):293-4. Related Articles, Links
Effectiveness of finasteride on patients with male pattern baldness who have different androgen receptor gene polymorphism.
Wakisaka N, Taira Y, Ishikawa M, Nakamizo Y, Kobayashi K, Uwabu M, Fukuda Y, Taguchi Y, Hama T, Kawakami M.
NPO Future Medical Laboratory, Tokyo, Japan.
Finasteride is not necessarily effective on all of the male pattern baldness (male pattern baldness) patients. To know any factor which correlates with the effectiveness of finasteride, the polymorphism of androgen receptor (AR) gene was analyzed. Symptoms of the 488 male pattern baldness patients (18-62 y) before and after treatment with total dose of 10 mg or more of finasteride was typed by photographic method. The number of CAG and GGC repeats in AR gene of male pattern baldness patients was determined by DNA sequencing. When the number of the triplet repeats (CAG + GGC) was plotted against the degree of symptom improvement after treatment with this drug, a broad correlation between these variables was observed. The smaller the repeat number, the higher the improvement with finasteride. The group of patients with shorter repeat region in AR gene responded better to this drug than that with longer repeat region, although the former patients tended to reveal severe initial symptoms. Determination of such polymorphism is thought to be useful in the drug choice for male pattern baldness patients.
PMID: 16382684 [PubMed - indexed for MEDLINE]
J Investig Dermatol Symp Proc. 2005 Dec;10(3):293-4. Related Articles, Links
Effectiveness of finasteride on patients with male pattern baldness who have different androgen receptor gene polymorphism.
Wakisaka N, Taira Y, Ishikawa M, Nakamizo Y, Kobayashi K, Uwabu M, Fukuda Y, Taguchi Y, Hama T, Kawakami M.
NPO Future Medical Laboratory, Tokyo, Japan.
Finasteride is not necessarily effective on all of the male pattern baldness (male pattern baldness) patients. To know any factor which correlates with the effectiveness of finasteride, the polymorphism of androgen receptor (AR) gene was analyzed. Symptoms of the 488 male pattern baldness patients (18-62 y) before and after treatment with total dose of 10 mg or more of finasteride was typed by photographic method. The number of CAG and GGC repeats in AR gene of male pattern baldness patients was determined by DNA sequencing. When the number of the triplet repeats (CAG + GGC) was plotted against the degree of symptom improvement after treatment with this drug, a broad correlation between these variables was observed. The smaller the repeat number, the higher the improvement with finasteride. The group of patients with shorter repeat region in AR gene responded better to this drug than that with longer repeat region, although the former patients tended to reveal severe initial symptoms. Determination of such polymorphism is thought to be useful in the drug choice for male pattern baldness patients.
PMID: 16382684 [PubMed - indexed for MEDLINE]
