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Amplifica, Hairy Moles, Osteopontin and SCUBE3
- Thread starter jondoeuk
- Start date
Amplifica's AMP-303 phase one trial results came out: ''A statistically significant percentage of study subjects showed a greater than 15% increase in non-vellus hair count from baseline compared to placebo at 60 days post-treatment, and a greater than 10% increase compared to placebo at 150 days post-treatment.'' https://amplificabio.com/amplificas-amp-303-study-unveils-new-hope-for-hair-loss-treatments/
Moreover, there were no major safety issues from the intradermal injections, and just a single AMP-303 treatment cycle increased non-vellus hair count. In addition, the increase in hair density and thickness was sustained over time (150 days post treatment). Best of all, the results demonstrated AMP-303's ability to transition vellus hairs into non-vellus hairs. This implies not just hair thickening, but also the far more difficult hair loss reversal.
Moreover, there were no major safety issues from the intradermal injections, and just a single AMP-303 treatment cycle increased non-vellus hair count. In addition, the increase in hair density and thickness was sustained over time (150 days post treatment). Best of all, the results demonstrated AMP-303's ability to transition vellus hairs into non-vellus hairs. This implies not just hair thickening, but also the far more difficult hair loss reversal.
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Amplifica published five-month results of a 61-person trial of AMP-303, described as a novel polysaccharide. https://www.jidonline.org/article/S0022-202X(25)01992-X/fulltext
The male subjects (all aged 18-45) with mild to moderate androgenetic alopecia (Norwood III-IV) were divided into two groups:
Group 1 (n=32): balding duration of 3-5 years.
Group 2 (n=29): balding duration of ≥10 years.
They all received AMP-303 injections on one side of the scalp in twenty frontotemporal locations, and saline injections on the other side. For the Group 1 responders, the mean increase in non-vellus hair count was 14.5% and it peaked at sixty days. The results remained significantly greater than saline through five months. AMP-303 showed durability of effect with one injection cycle and led to hair terminalisation. Unfortunately, nothing is said about the Group 2 responders who had been balding for ten years or longer.
The male subjects (all aged 18-45) with mild to moderate androgenetic alopecia (Norwood III-IV) were divided into two groups:
Group 1 (n=32): balding duration of 3-5 years.
Group 2 (n=29): balding duration of ≥10 years.
They all received AMP-303 injections on one side of the scalp in twenty frontotemporal locations, and saline injections on the other side. For the Group 1 responders, the mean increase in non-vellus hair count was 14.5% and it peaked at sixty days. The results remained significantly greater than saline through five months. AMP-303 showed durability of effect with one injection cycle and led to hair terminalisation. Unfortunately, nothing is said about the Group 2 responders who had been balding for ten years or longer.
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Amplifica raised $26 million in a Series B Preferred Stock financing round. Of particular note, one of the investors is Eli Lilly (US), which also invested in Absci (US) earlier this year. https://amplificabio.com/amplifica-...-advance-injectable-pipeline-for-hair-growth/
What would you prefer: to chemically castrate yourself with finasteride and ruin your heart with minoxidil just to delay the inevitable? Or to inject a sugar into your scalp that stops hair loss and, on top of that, produces 20% hair regrowth?It's less cope than PP405 but that's a very low bar. This won't do much either.
Let me put the question differently: which would you prefer for your son?