Alternate Pathway That Testosterone Gets Converted To Dht

[BaldingHelpMe]

Found this article:

http://www.ilht.com/mechanism-of-male-pattern-hair-loss.php

It says there are two pathways, one requires 5AR enzymes, and alternate pathway that does not involved 5AR enzymes, that explains why finasteride/dutasteride may not be effective on some people.

This is worrying! Does this alternate pathway happen to everyone? Or just some people? I don't understand, how does testosterone get converted to DHT with just blood circulation?


From the article:

Alternate pathways

Testosterone can get converted into DHT in the blood circulation. The circulating DHT in the blood enter in the tissues including scalp tissue. In the scalp tissue DHT enter into hair follicle cells, mainly the papilla cells, outer root sheath cells and sebaceous gland cells. DHT might bind to different receptors rather binding to Androgen Receptors in the cytosol of papilla cells , outer root sheath cell and sebaceous gland cells and enter into the nucleus and bind to the DNA leads to production of cell specific mRNA and synthesis of specific proteins that lead to progressive miniaturization of hair and hair loss. As these alternate pathways does not involve 5 alpha reductase, finesteride is not effective.

 

[Nadia1972]

I have not understood everything and the texts are a little hard to include.If I understood,DHT is not became for everyone into 5AR ? And what about women ?

 

[BaldingHelpMe]

Basically what it is saying is that, there is an alternate pathway for testosterone to get converted to DHT without 5 alpha reductase enzymes.

I don't know if it's true, and this occurs to only a small number of people, or not. But if it's true, this is very worrying!

 

[Nadia1972]

Basically what it is saying is that, there is an alternate pathway for testosterone to get converted to DHT without 5 alpha reductase enzymes.

I don't know if it's true, and this occurs to only a small number of people, or not. But if it's true, this is very worrying!

If there is no 5AR , in principle, there is no baldness , right?

 

[BaldingHelpMe]

If there is no 5AR , in principle, there is no baldness , right?

If there is no 5AR (the environment finasteride/dutasteride tries to create), there is no DHT, therefore there should be no baldness.

But that the article above says that, there are other pathways leading to DHT without 5AR. So, this is very worrying, and I hope it's not true, or at least not common.

 

[Nadia1972]

I apologize for my idiote,theDHT does not necessarily produce the 5AR ?

 

[Armando Jose]

Found this article:

http://www.ilht.com/mechanism-of-male-pattern-hair-loss.php

It says there are two pathways, one requires 5AR enzymes, and alternate pathway that does not involved 5AR enzymes, that explains why finasteride/dutasteride may not be effective on some people.

This is worrying! Does this alternate pathway happen to everyone? Or just some people? I don't understand, how does testosterone get converted to DHT with just blood circulation?


From the article:

Alternate pathways

Testosterone can get converted into DHT in the blood circulation. The circulating DHT in the blood enter in the tissues including scalp tissue. In the scalp tissue DHT enter into hair follicle cells, mainly the papilla cells, outer root sheath cells and sebaceous gland cells. DHT might bind to different receptors rather binding to Androgen Receptors in the cytosol of papilla cells , outer root sheath cell and sebaceous gland cells and enter into the nucleus and bind to the DNA leads to production of cell specific mRNA and synthesis of specific proteins that lead to progressive miniaturization of hair and hair loss. As these alternate pathways does not involve 5 alpha reductase, finesteride is not effective.

Found this article:

http://www.ilht.com/mechanism-of-male-pattern-hair-loss.php

It says there are two pathways, one requires 5AR enzymes, and alternate pathway that does not involved 5AR enzymes, that explains why finasteride/dutasteride may not be effective on some people.

This is worrying! Does this alternate pathway happen to everyone? Or just some people? I don't understand, how does testosterone get converted to DHT with just blood circulation?


From the article:

Alternate pathways

Testosterone can get converted into DHT in the blood circulation. The circulating DHT in the blood enter in the tissues including scalp tissue. In the scalp tissue DHT enter into hair follicle cells, mainly the papilla cells, outer root sheath cells and sebaceous gland cells. DHT might bind to different receptors rather binding to Androgen Receptors in the cytosol of papilla cells , outer root sheath cell and sebaceous gland cells and enter into the nucleus and bind to the DNA leads to production of cell specific mRNA and synthesis of specific proteins that lead to progressive miniaturization of hair and hair loss. As these alternate pathways does not involve 5 alpha reductase, finesteride is not effective.

Is it the link you used?
https://www.researchgate.net/post/D...he_intracellular_conversion_from_Testosterone

 

[Armando Jose]

Found this article:

http://www.ilht.com/mechanism-of-male-pattern-hair-loss.php

It says there are two pathways, one requires 5AR enzymes, and alternate pathway that does not involved 5AR enzymes, that explains why finasteride/dutasteride may not be effective on some people.

This is worrying! Does this alternate pathway happen to everyone? Or just some people? I don't understand, how does testosterone get converted to DHT with just blood circulation?


From the article:

Alternate pathways

Testosterone can get converted into DHT in the blood circulation. The circulating DHT in the blood enter in the tissues including scalp tissue. In the scalp tissue DHT enter into hair follicle cells, mainly the papilla cells, outer root sheath cells and sebaceous gland cells. DHT might bind to different receptors rather binding to Androgen Receptors in the cytosol of papilla cells , outer root sheath cell and sebaceous gland cells and enter into the nucleus and bind to the DNA leads to production of cell specific mRNA and synthesis of specific proteins that lead to progressive miniaturization of hair and hair loss. As these alternate pathways does not involve 5 alpha reductase, finesteride is not effective.

Found this article:

http://www.ilht.com/mechanism-of-male-pattern-hair-loss.php

It says there are two pathways, one requires 5AR enzymes, and alternate pathway that does not involved 5AR enzymes, that explains why finasteride/dutasteride may not be effective on some people.

This is worrying! Does this alternate pathway happen to everyone? Or just some people? I don't understand, how does testosterone get converted to DHT with just blood circulation?


From the article:

Alternate pathways

Testosterone can get converted into DHT in the blood circulation. The circulating DHT in the blood enter in the tissues including scalp tissue. In the scalp tissue DHT enter into hair follicle cells, mainly the papilla cells, outer root sheath cells and sebaceous gland cells. DHT might bind to different receptors rather binding to Androgen Receptors in the cytosol of papilla cells , outer root sheath cell and sebaceous gland cells and enter into the nucleus and bind to the DNA leads to production of cell specific mRNA and synthesis of specific proteins that lead to progressive miniaturization of hair and hair loss. As these alternate pathways does not involve 5 alpha reductase, finesteride is not effective.

Is it the link you used?
https://www.researchgate.net/post/D...he_intracellular_conversion_from_Testosterone

 

[BaldingHelpMe]

Is it the link you used?
https://www.researchgate.net/post/D...he_intracellular_conversion_from_Testosterone

No, this article: http://www.ilht.com/mechanism-of-male-pattern-hair-loss.php

 

[Nadia1972]

This seems to be the case.
I begin to understand the role of DHT in the bloodstream

 

[BaldingHelpMe]

I apologize for my idiote,theDHT does not necessarily produce the 5AR ?

That's what the article says. There might be a pathway that Testosterone gets converted to DHT without the need of 5AR.

 

[AlwaysRock]

But 5 AR II deficent people (pseudohermaphrodits) never get male pattern baldness. So no need to worry !

 

[BaldingHelpMe]

But 5 AR II deficent people (pseudohermaphrodits) never get male pattern baldness. So no need to worry !

Yeah, but the thing is, they were born in that way, and we weren't. Also, we take these drugs after puberty when DHT has already done its job of maturing our bodies. If we defeat the 5AR with these drugs, what if our bodies find a way to convert testosterone into DHT without 5AR? That also explains why drugs like finasteride and dutasteride do not work for some people.

 

[Nadia1972]

I am a women.I have an agressive Androgenetic Alopecia.My sisters were not touched but all my brothers are.My testosterone is normal.
Is that women produce less DHT than men ? Alopecia is hereditary in my family.My case is the first situation,heredatary Androgenetic Alopecia or Androgenetic Alopecia because of the blood circulation

 

[GoldenMane]

Well finasteride/dutasteride prevent conversion of test to DHT, but equol binds to DHT itself, rendering it inactive. So if finasteride/dutasteride don't work then maybe Brotzu's lotion will, I think the active ingredient is converted to equol.

 

[BaldingHelpMe]

I am a women.I have an agressive Androgenetic Alopecia.My sisters were not touched but all my brothers are.My testosterone is normal.
Is that women produce less DHT than men ? Alopecia is hereditary in my family.My case is the first situation,heredatary Androgenetic Alopecia or Androgenetic Alopecia because of the blood circulation

A naturally born woman or transgendered woman? If it's naturally born woman, it's called female patterned baldness, which is a topic I'm not familiar. It's different.

 

[Nadia1972]

naturally woman with normal testosterone for a woman.
But is Androgenetic Alopecia in women operate in the same way that men ? Are they studies about it ?

 

[BaldingHelpMe]

Well finasteride/dutasteride prevent conversion of test to DHT, but equol binds to DHT itself, rendering it inactive. So if finasteride/dutasteride don't work then maybe Brotzu's lotion will, I think the active ingredient is converted to equol.

But that's not something widely available now, or something I can get in drug store now.

naturally woman with normal testosterone for a woman.
But is Androgenetic Alopecia in women operate in the same way that men ? Are they studies about it ?

It's different than male patterned baldness.

 

[Nadia1972]

The fall is not the same but is that DHT plays a role ?
If dutasteride and finasteride don't work for some people that's means perhaps DHT is not involved .For some women also Androcur and estrogen sometimes do not act.Maybe the DHT is not within the operation of all Androgenetic Alopecia.

 

[GoldenMane]

DHT definitely isn't the only cause of baldness but it is the prime culprit in Androgenetic Alopecia.
Many foods contain s equol or can be converted into it. As s supplement or topical it is not widely available but it is possible to obtain it now in various ways if you think DHT is being produced another way