Aaaand it failed. Get on the dutasteride children.
https://clinicaltrials.gov/ct2/show/results/NCT02781311
https://clinicaltrials.gov/ct2/show/results/NCT02781311
Allergen Seti Trial Results Have Been Posted
- Thread starter Fgsfds
- Start date
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- 221
Welp, now we know. Hate that we can’t compare this to finasteride. After reading the results, there still could have been some slight chance this is beneficial for maintenance. However, between the study’s length and dropping finasteride we will never know.
Feel terrible for those who paid tons of money for this stuff.
bluesuedeshoes
Established Member
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- 96
Wow, that Placebo drug really messed up some folk. Two guys got testicular pain, another poor sod got Bronchitis and three people got the flu.
Guess we need to careful and watch out for any sides with that one. Definitely has me wary of trying it.
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The mind is a powerful thing, if you look at finasteride study, wasn't much difference between placebo and drug for sexual sides.
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Says it all, doesn’t it. Take peoples’ anecdotes with a pinch of salt.
HairlossCurse
Member
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It is quite unreal how it did nothing, given paper study used it on human follicles and it worked. I wonder if it being in pill form had an impact, as in paper it was applied directly. I wonder if a good cream version that guarantees delivery to the follicle will work, but I guess we will never know now
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it seems that ex-vivo testing with human follicles is not as good as one could consider.
sandalore and cm-3 show notorius growth ex-vivo, but in vivo...... we don't know.
also we will never know if seti works as a topical, exactly like ketoconazole.
at least we know that there's no point on using an oral route.
what impresses me the most is that the placebo group regrew hair, meaning that Androgenetic Alopecia is not
straightforward progressive , it's more like waves of devastation and slight recovery
sandalore and cm-3 show notorius growth ex-vivo, but in vivo...... we don't know.
also we will never know if seti works as a topical, exactly like ketoconazole.
at least we know that there's no point on using an oral route.
what impresses me the most is that the placebo group regrew hair, meaning that Androgenetic Alopecia is not
straightforward progressive , it's more like waves of devastation and slight recovery
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I think a lot of us saw this coming, but were hoping for a miracle. All of that hype for nothing. Sorry everyone )=
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Don’t worry guys, fevipiprant is much stronger.
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Sorry, but I believe it says "Setipiprant, 1000 mg (2 x 500 mg) tablets, orally, BID at 12-hour intervals for 24 weeks."
BID stands for "bis in die" and is medical terminology for twice daily dosage.
What the description says is that the patient gets 500 mg pills, and has to take two of them to get the correct dose of 1g, and has to dose twice a day, twelve hours apart between doses.
So to be clear, it is indeed 2 g of Seti per day.
But I agree with your sentiment on how utterly ineffective it appears despite the hype.
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I think this quote that was posted by another user about another study (I can't find the study) tells us why Fevi won't work either
.Apparently it is from a study published February 2019
"It has been suggested that inhibitors of PTGDR2 may reverse hair growth through inhibition by PGD2 activity[6]. A multicenter, randomized, double -blind, placebo -controlled, Phase 2A study of setipiprant (oral PTGD2 receptor antagonist) 500 mg tablets BID in Androgenetic Alopecia is being performed (ClinicalTrials.gov Identifier: NCT02781311). It is interesting that this receptor is not overexpressed in our patients. Perhaps research on treatment should focus on drugs that target PTGDS activity and not PTGDR2."
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Interesting...