Bryan said:
tino said:
This deliverances from greece or egypt,whatever....are scientific non valid,because informations like for example,what will happen when a castrated subject will get thyroid disease,or has low Iron are missing.Noone investigated that....the only thing they saw is,that there was a difference to their genetic kinsman,when castrated.What makes you so sure that they keeped their hair full and healthy until they died?Again,Castration does maybe stopp further progression of androgen induced Apoptotic influence,but it can do nothing for other influences.The complete inhibition of a important hormone,is no adhesive tape for hair and skin aging.
I've watched this back-and-forth discussion with some amusement, and I agree with Michael Barry that the genetic factor having to do with the response to androgens is BY FAR the most important component of
androgenetic alopecia. Having said that, I don't doubt that some of these other peripheral issues (like having to do with antioxidants and various nutritional factors) have _some_ relevance for balding, but I think they are minor issues. If I were forced to put a number to it, I'd make a wild guess and say that maybe they are only 5% or so of the problem.
Your statements above about thyroid disease and "low iron" problems are themselves pretty irrelevant, because the issue here is true
androgenetic alopecia, not other forms of hairloss.
citation:Your statements above about thyroid disease and "low iron" problems are themselves pretty irrelevant, because the issue here is true androgenetic alopecia, not other forms of hairloss.
Oh bryan,im very surprised
If there is a praedispostion to male pattern baldness.....(i would like to call it genetic patttern baldness here,because i dont belive that every so called male pattern baldness is strong androgen dependet),than the androgenic influence,for example in cases of rather long CAG Repeats,must not be so strong,that it reduces other known APOPTOSIS inducing influences to a minimum.Week genetic meets one strong trigger like for example iron deficiney,or bad adjusted thyroid disease,or week genetic meets more week trigger together,like for example zinc deficiency,latent malnutrition,smoking,Stress.
For example.....
http://www.nature.com/jid/journal/v121/ ... 2007a.html
what is to fault whith that?
I think you know the works about stress and apoptosis of HF.....and i think you also saw the study about Caspase-3 and Zink i have posted.
Men do not develop hair loss due Iron deficiency,thyorid diseases,or whatever?Ok you can argument that the hairloss in such cases will be diffuse.But think about the lack of resistance,once attacked/insufficient hair follicles have against all the winds.The hair follicle is a little hormonal factory,which has the capacity to protect himself,when he is young.Old hair follicles fall quicker,like old men,when they develop pneumonia.Its absoloutly logical,that aged follickles will fall as first,under bad influences from every direction.
Ok,we can get agreed,when we talk about cases,which show extreme strong progression in their mid twenties,signed due quick temple receeding,and Tonsur.In such cases,i think that
genetic can override triggers.And maybe then,in Fact androgenes have the strongest influence.
But what about temple receeding guys like Johnny deep,Tom Selleck,or unknown people,who develop a slow
patternd thinning in their 30 for the first time?Is that really classic male pattern baldness,basically induced due the prooven Androgenetic pathogenesis?Sure...normal non scientific working doctors would say yes....under appointment of JB Hamilton
