Accutane: Can It Cause Or Accelerate Male Pattern Baldness?

Kerzenlich24

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I've read a bunch of posts on different sites of guys claiming that Accutane accelerated or kickstarted their male pattern baldness. I couldn't find any studies or articles that acutally confirm this and most of those guys claim to have a family history of male pattern baldness. The only thing that I could find was a theory stating that people who already have Male Pattern Baldness could see a faster progression of their hair loss due to the temporal telogen effluvium, causing more hair shedding which won't grow back due to their male pattern baldness
Does anyone know something about this? Both of my grandfathers started balding at age 70+, so I don't know if I should even be worried. But I really want to know if Accutane can kickstart male pattern baldness
 

Ikarus

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Accutane does have the potential to do that, but it’s not worth worrying about since it’s not common. You should more so worry about the effects it will have on your liver, which is the most significant issue in my opinion.
 

Kerzenlich24

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Accutane does have the potential to do that, but it’s not worth worrying about since it’s not common. You should more so worry about the effects it will have on your liver, which is the most significant issue in my opinion.
Yea i worried a lot about my liver in the first few weeks but since I was on a low dose I kind of stopped worrying and could even consume alcohol without any problems.
 

Ikarus

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Yea i worried a lot about my liver in the first few weeks but since I was on a low dose I kind of stopped worrying and could even consume alcohol without any problems.

I mean, on blood tests. With Accutane, a large issue is raised liver enzymes; alcohol contributes to that. Therefore, if your blood tests show liver abnormalities, chances are that you will be taken off the medication.
 

Ikarus

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Another type of poison. A lot of people had chronic side effects even after quitting accutane fyi.

Side Effects Of Accutane Use: Depression, Autoimmune Disease, Liver Damage, And Pancreatitis
Properly diving into the dangers of Accutane would turn this 4,000 word article into a book. But the bottom line is this: Accutane is a synthetic derivative of retinol, and high dosages, retinol is extremely toxic.

Problem #1: Retinol Toxicity
In fact, retinol toxicity — or hypervitaminosis A — is why you should never eat polar bear liver. It’s extremely high in retinol, and our bodies can’t metabolize surging amounts of retinol all at once. If we try, our livers and pancreas will likely shut down.

Problem #2: Accutane Decreases Brain Activity In The Frontal Cortex
Accutane is synthetic — meaning it is a chemical derivative that mimics the look of natural-occurring retinoids. Our bodies don’t always read synthetic chemicals the same way they do their naturally-occurring molecular counterparts. And this “difference” tends to play out in Accutane’s effects on brain activity.

In fact, one study suggests that Accutane users experienced a 21% decrease in brain metabolism in the orbito-frontal cortex. This partly explains why Accutane users have to be monitored closely for depression and suicidal thoughts.

Problem #3: Accutane May Be A Trigger To Autoimmune Thyroid Disease
Accutane is also linked to increased incidences of irritable bowel syndrome and Crohn’s disease. With that said, the scientific consensus on association versus causation is still up for debate — and without a clear mechanism action, we can’t make any major claims.

However, Isotretinoin drugs (like Accutane) may also play a role in the development of autoimmune-based thyroid disease — at least according to this case study. But evidence here is still being explored.

Problem #4: Accutane Has Already Been Discontinued (But Not Really)
Since 2009, the brandname Accutane is no longer available as an acne treatment. This is the result of a series of class action lawsuits and litigation troubles for the drug maker, Roche USA.

But that doesn’t mean you still can’t get Accutane. In fact, Accutane is just one brand name for the drug isotretinoin. Isotretinoin is still available as a generic drug — and now comes packages as several other brand names.

So if you’re suffering from a p. acnes overgrowth and have acne (and maybe even hair loss), what should you do?

I wouldn’t bother with most of those potential side effects, they’re not too common with lower doses. With using Accutane, the biggest concerns with doctors is liver abnormalities since that is more so a common side effect of using the medication. In fact, it can lead to serious hepatic issues, which is why drinking is not recommended on Accutane (people who drink alcohol whilst on Accutane are insanely stupid). Another potential issue with Accutane is depression, which seems to be an increased likelihood when a higher dose is used.

Otherwise, the general side effects are: joint pains, dry lips and skin, nose bleeds, and dry eyes. Most of the side effects can be combatted; using Aquaphor on your lips is insanely helpful whilst on Accutane. For your skin, many dermatologist recommend using CeraVe and Cetaphil, but in my opinion there are much better products for your skin to help with the dryness. Drinking a lot of water helps too.
 

justbeconfident

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are you already on accutane?

yeah, basically the hair loss side effect is the only single reason why i havent jumped on it yet

ive known 2 guys personally that had to hop on finasteride and minoxidil after accutane course, because it started their baldness

also as evidence shows from the feedback on the web, many guys complain on realself and other sites that accutane kickstarted their hair
 

Armando Jose

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What the research says about hair loss
Hair loss, which can include a reduction in hair count and hair density, is an undesirable side effect of isotretinoin treatment. A 2013 study showed that this hair loss was temporary, although hair thinning may continue after treatment has stopped.

According to the American Osteopathic College of Dermatology (AOCD), about 10 percent of Accutane users experience temporary hair thinning.

A 2018 study, however, found that isotretinoin doesn’t affect short-term hair growth. It also concluded that hair growth is only affected when people take very high doses of the drug.

https://www.healthline.com/health/hair-loss-on-accutane#what-the-research-says
 

Kerzenlich24

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are you already on accutane?

yeah, basically the hair loss side effect is the only single reason why i havent jumped on it yet

ive known 2 guys personally that had to hop on finasteride and minoxidil after accutane course, because it started their baldness

also as evidence shows from the feedback on the web, many guys complain on realself and other sites that accutane kickstarted their hair
I was on accutane for about a year and 4 months, i took a very low dose (10mg at the beginning and about 1.5mg a day at the end) and I became very paranoid about hair loss, but I dont think that I experienced any (maybe some very light shedding but could've been seasonal shedding)

I've also read a lot of articles in which guys were blaming accutane for their male pattern baldness. And I've noticed that all of those guys either have a family history of male pattern baldness at a young age or were just experiencing telogen effluvium for quite a long time but didn't know the difference between Telogen Effluvium and male pattern baldness.
Also, guys who take accutane are mostly16-20 years old which is exactly when male pattern baldness can first occur and accepting the hair loss can be something very hard especially when you're that young which is why many just blame the accutane for their hair loss, even tho theres no evidence that it can activate male pattern baldness.
So I don't think that accutane can kickstart your male pattern baldness, but it certainly can speed up the rate at which you're losing your hair.
 

Armando Jose

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Accutane = isotretinoin and supress sebum production, not only in the face but in scalp hairs, I will bet that prone people are persons with thiner and sparse hair.
 

Kerzenlich24

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What the research says about hair loss
Hair loss, which can include a reduction in hair count and hair density, is an undesirable side effect of isotretinoin treatment. A 2013 study showed that this hair loss was temporary, although hair thinning may continue after treatment has stopped.

According to the American Osteopathic College of Dermatology (AOCD), about 10 percent of Accutane users experience temporary hair thinning.

A 2018 study, however, found that isotretinoin doesn’t affect short-term hair growth. It also concluded that hair growth is only affected when people take very high doses of the drug.

https://www.healthline.com/health/hair-loss-on-accutane#what-the-research-says

Do you maybe know what exactly they meant with "short term hair growth", does this refer to miniaturization or just the speed of hair growth?
 

Armando Jose

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Do you maybe know what exactly they meant with "short term hair growth", does this refer to miniaturization or just the speed of hair growth?

Yes, Using "short term hair growth" it is unuseless without figures, one hair cycle is about 4/5/6 years and I dont know anyone using roaccutane this period.
And sadly n the 2018 study they used occipital and parietals hairs, to avoid the false results of androgen exposure in male patients. !!!

So I don't think that accutane can kickstart your male pattern baldness, but it certainly can speed up the rate at which you're losing your hair.

IMHO not only can speed up but also kickstart the process, My idea is that problems with sebum flow is the initial factor in this multifactorial and degenerative process, common baldness
 
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Kerzenlich24

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Yes, Using "short term hair growth" it is unuseless without figures, one hair cycle is about 4/5/6 years and I dont know anyone using roaccutane this period.


IMHO not only can speed up but also kickstart the process, My idea is that problems with sebum flow is the initial factor in this multifactorial and degenerative process, common baldness
Can you maybe elaborate on that?
And also, do you think that age plays a role in this kickstart of male pattern baldness due to accutane?
In other words, do you believe that accutane is able to kickstart male pattern baldness in a youn person who would've started balding in his late 60s or 70s?

I'm also pretty sure that the article that you cited was refering to temporary telogen effluvium and not androgenetic alopecia
 
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Armando Jose

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A young person with short,thin hair and low hair density, could develope common baldness using meds that supress sebum. Acording to my idea, sebum is vital for a healthy scalp hair, but sebum needs renovate continously due at its inestable mixture, then if you reduce the sebum production also can alter the sebum flow. Then sebum will oxidice (rancid) and start the process of this malatie, oxidatión, inflammation, patogens, hormones, fibrosis etc.
 

Kerzenlich24

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A young person with short,thin hair and low hair density, could develope common baldness using meds that supress sebum. Acording to my idea, sebum is vital for a healthy scalp hair, but sebum needs renovate continously due at its inestable mixture, then if you reduce the sebum production also can alter the sebum flow. Then sebum will oxidice (rancid) and start the process of this malatie, oxidatión, inflammation, patogens, hormones, fibrosis etc.
Ok got it, but do you think that this is permanent?
 

Armando Jose

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Do you maybe know what exactly they meant with "short term hair growth", does this refer to miniaturization or just the speed of hair growth?

Ah, I found it, short term referes three months, they measure in a 3 months intervale,
For me is OK because common baldness is a slow process in the initial stage
 

Armando Jose

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Ok got it, but do you think that this is permanent?

Passing the time is more irreversible, and at the end possibly permanent (As seen in the population). More events as inmmune response, fibrosis, make the possible regeneration more difficult, sure.

Then, prevention better than cure.
Prevention is stop the process, this could be a good goal.
Cure, very difficult but impossible
 

Kerzenlich24

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Passing the time is more irreversible, and at the end possibly permanent (As seen in the population). More events as inmmune response, fibrosis, make the possible regeneration more difficult, sure.
Ok thanks for sharing your hairloss theory. Never heard of anything like this but it sure seems interesting.
 
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