Someone's Mom said:I wasn't asking for a diagnosis.
Thinning said:Too bad, you asked what people thought, thats what I though, lol.
Thinning said:you will find that there are tons of people on this site wanting to find some reason why there hair is falling out, and dont want to accept that its due to plain old pattern baldness.
Thinning said:Someone's Mom said:Here's a few pics of my son's progress. There are 2 from May 2006 before starting the regimen and 4 from Oct 2006, 5 months into it.
http://img235.imageshack.us/img235/1265/progressiz9.jpg
What do you all think?
Looks like male pattern baldness to me.
Old Baldy said:What does hair loss caused by Accutane look like Thinning?
s.a.f said:but given this kids age and the fact that the hairloss happened after taking accutane I'd guess that it does have something to do with the drug.
Hey,Someone's Mom said:Thinning said:Too bad, you asked what people thought, thats what I though, lol.
I was asking what people thought about the new temple/hairline growth after 5 months :shock:
My main reason for posting here was that I read and learned a lot from these forums and hundreds of pages of info during my research. I wanted to let people know that Accutane does cause hair loss (or as Roche parses it "an abscence of hair" :evil: ) in some people...more than your doctor or Roche will admit to. It's not a theory, it's a fact, and people should consider that if they're using now or have used it in the past, or plan to use it in the future. Some people will think the risk is worth it, some won't. I think it's important that people have all the info.
So, yes, based on everything I now know, I believe Accutane caused his male pattern baldness to start early. Still, in spite my research and the conversations with Roche and with his Dr admitting it, the bottom line now is how to reverse it, or at least control it. Hence the minoxidil/Propecia/etc plan which seems to be working.
Thinning said:Old Baldy said:What does hair loss caused by Accutane look like Thinning?
It falls out all over, doesent recede at the temples like male pattern baldness. Similar to chemo hairloss - its actually Vitamin A poisoning.
Thats why I think this kid just has male pattern baldness, clear temple recession, thinning in the norwood profile. Its not that odd for a 20 year old, I knew kids in highschool with worse pattern baldness than him.
Thinning said:It falls out all over, doesent recede at the temples like male pattern baldness. Similar to chemo hairloss - its actually Vitamin A poisoning.
Someone's Mom said:One of the common threads I've seen with anyone who thinks their hair loss was Accutane related is: their hair loss appeared much earlier in life than expected.
OH god i was never told this by my Doctor. So this means that accutane may have speeded yp my male pattern baldness? What to you think can help the situation ?docj077 said:I don't know if this matters in this thread or not, but I thought this study seemed important. This is in vitro or basically in the test tube, but it's important to note that retinoids seem to cause the exact same downstream effects that androgens do when it comes to hair loss. If they do indeed develop these TGF-beta II antagonists and receptor antagonists as planned, it would be a huge leap forward for every man or woman with androgenic alopecia or retinoid-induced alopecia. It would be a very real life long application of a cure.
1: J Invest Dermatol. 2005 Jun;124(6):1119-26.
Towards dissecting the pathogenesis of retinoid-induced hair loss: all-trans retinoic acid induces premature hair follicle regression (catagen) by upregulation of transforming growth factor-beta2 in the dermal papilla.Foitzik K, Spexard T, Nakamura M, Halsner U, Paus R.
Department of Dermatology, University Hospital Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany.
Diffuse hair loss ranks among the most frequent and psychologically most distressing adverse effects of systemic therapy with retinoids, which severely limits their therapeutic use even where clinically desired. Since the underlying mechanisms of retinoid-induced effluvium are as yet unknown, we have investigated the influence of the prototypic retinoid all-trans retinoic acid (ATRA, tretinoin) on the growth of human scalp hair follicles (HF) in culture. HF in the anagen VI stage of the hair cycle were cultured in the presence of 10(-8) or 10(-10) M ATRA. Compared with controls, hair shaft elongation declined significantly already after 2 d in the ATRA-treated group, and approximately 80% of the ATRA-treated HF had prematurely entered catagen-like stage at day 6, compared with 30% in the control group. This corresponded to an upregulation of apoptotic and a downregulation of Ki67-positive cells in ATRA-treated HF. Since transforming growth factor (TGF)-beta has been implicated as a key inducer of catagen, we next studied whether ATRA treatment had any effect on follicular expression. TGF-beta2 immunoreactivity was detected in the outer root sheath of anagen VI scalp HF. In catagen follicles, TGF-beta2 was also expressed in the regressing epithelial strand. After 4 d of ATRA treatment, TGF-beta2 was significantly upregulated in anagen HF in the dermal papilla (DP) and the dermal sheath, 7, and TGF-beta neutralizing antibody partially abrogated at RA induced hair growth inhibition. Real-time PCR confirmed a significant upregulation of TGF-beta2 transcripts in ATRA-treated hair bulbs. This study is the first to provide direct evidence that ATRA can indeed induce a catagen-like stage in human HF and suggests that this occurs, at least in part, via upregulation of TGF-beta2 in the DP. Therefore, topical TGF-beta2/TGF-beta receptor II antagonists deserve to be explored for the prevention and management of retinoid-induced hair loss.
HARM1 said:OH god i was never told this by my Doctor. So this means that accutane may have speeded yp my male pattern baldness? What to you think can help the situation ?docj077 said:I don't know if this matters in this thread or not, but I thought this study seemed important. This is in vitro or basically in the test tube, but it's important to note that retinoids seem to cause the exact same downstream effects that androgens do when it comes to hair loss. If they do indeed develop these TGF-beta II antagonists and receptor antagonists as planned, it would be a huge leap forward for every man or woman with androgenic alopecia or retinoid-induced alopecia. It would be a very real life long application of a cure.
1: J Invest Dermatol. 2005 Jun;124(6):1119-26.
Towards dissecting the pathogenesis of retinoid-induced hair loss: all-trans retinoic acid induces premature hair follicle regression (catagen) by upregulation of transforming growth factor-beta2 in the dermal papilla.Foitzik K, Spexard T, Nakamura M, Halsner U, Paus R.
Department of Dermatology, University Hospital Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany.
Diffuse hair loss ranks among the most frequent and psychologically most distressing adverse effects of systemic therapy with retinoids, which severely limits their therapeutic use even where clinically desired. Since the underlying mechanisms of retinoid-induced effluvium are as yet unknown, we have investigated the influence of the prototypic retinoid all-trans retinoic acid (ATRA, tretinoin) on the growth of human scalp hair follicles (HF) in culture. HF in the anagen VI stage of the hair cycle were cultured in the presence of 10(-8) or 10(-10) M ATRA. Compared with controls, hair shaft elongation declined significantly already after 2 d in the ATRA-treated group, and approximately 80% of the ATRA-treated HF had prematurely entered catagen-like stage at day 6, compared with 30% in the control group. This corresponded to an upregulation of apoptotic and a downregulation of Ki67-positive cells in ATRA-treated HF. Since transforming growth factor (TGF)-beta has been implicated as a key inducer of catagen, we next studied whether ATRA treatment had any effect on follicular expression. TGF-beta2 immunoreactivity was detected in the outer root sheath of anagen VI scalp HF. In catagen follicles, TGF-beta2 was also expressed in the regressing epithelial strand. After 4 d of ATRA treatment, TGF-beta2 was significantly upregulated in anagen HF in the dermal papilla (DP) and the dermal sheath, 7, and TGF-beta neutralizing antibody partially abrogated at RA induced hair growth inhibition. Real-time PCR confirmed a significant upregulation of TGF-beta2 transcripts in ATRA-treated hair bulbs. This study is the first to provide direct evidence that ATRA can indeed induce a catagen-like stage in human HF and suggests that this occurs, at least in part, via upregulation of TGF-beta2 in the DP. Therefore, topical TGF-beta2/TGF-beta receptor II antagonists deserve to be explored for the prevention and management of retinoid-induced hair loss.
Hey there, thanks for your help.docj077 said:HARM1 said:docj077 said:I don't know if this
Well, this drug may not have caused this effect for you. This is a known side effect, but the doctor may not have known this when you were taking the drug.
Scientists are just now breaking down why it happens, but it's a very real possibility that the accutane didn't help.
I'm pretty sure that the company that makes accutane has listed hair loss as a side effect now. It wouldn't surprise me if they did that so people couldn't sue them for wrong doing. Isn't it, once they inform you, you have a year to press charges or else the statute of limitations runs out? I suck with legal stuff, but it goes something like that.
HARM1 said:docj077 said:HARM1 said:Hey there, thanks for your help.docj077 said:I don't know if this
Well, this drug may not have caused this effect for you. This is a known side effect, but the doctor may not have known this when you were taking the drug.
Scientists are just now breaking down why it happens, but it's a very real possibility that the accutane didn't help.
I'm pretty sure that the company that makes accutane has listed hair loss as a side effect now. It wouldn't surprise me if they did that so people couldn't sue them for wrong doing. Isn't it, once they inform you, you have a year to press charges or else the statute of limitations runs out? I suck with legal stuff, but it goes something like that.
I'm very sad to learn that accutane may have damged my hair.Do you think that it started the temple reccesion i have, but after stoping the accutane the balding will stop and happen when it was suppose to happen, or the accutane started the male pattern baldness process all over, earlier the it was sippose to be?
I'm of the drug for like 2 years, but my hair problems started after using it. Do you think there is a way to check if the VITAMIN A overdose is what caused my early male pattern baldness?docj077 said:HARM1 said:docj077 said:HARM1 said:Hey there, thanks for your help.docj077 said:I don't know if this
Well, this drug may not have caused this effect for you. This is a known side effect, but the doctor may not have known this when you were taking the drug.
Scientists are just now breaking down why it happens, but it's a very real possibility that the accutane didn't help.
I'm pretty sure that the company that makes accutane has listed hair loss as a side effect now. It wouldn't surprise me if they did that so people couldn't sue them for wrong doing. Isn't it, once they inform you, you have a year to press charges or else the statute of limitations runs out? I suck with legal stuff, but it goes something like that.
I'm very sad to learn that accutane may have damged my hair.Do you think that it started the temple reccesion i have, but after stoping the accutane the balding will stop and happen when it was suppose to happen, or the accutane started the male pattern baldness process all over, earlier the it was sippose to be?
I really don't know. If it concerns you, talk with your doctor and see if you could possibly switch medications.