waynakyo
Experienced Member
- Reaction score
- 466
This is just an excellent paper that does not deserve to be buried in the academic section (that no one reads).
Here is the full paper:
Here a corresponding patent:
patents.justia.com
Interesting things about the paper: It is not only rats. They look at living human hair follicles (ex-vivo = outside the body). They also look at ex vivo human tissue to see whether it is transdermally deliverable and the answer is yes. They also do that on actual humans on the buttocks and they tell you the concentration (Each designated concentration of P5 (0.075, 0.75, 1.5, or 7.5 mM) was prepared in vehicle (30% ethanol and 70% polyethylene glycol, v/v). The vehicle and four concentrations of P5 were topically applied on the left buttock of human and occluded. After 24 h, we acquired full thickness skin tissue using a 6 mm punch for subsequent analysis.)
Clearly they do not say that these results portend a success in a clinical setting. But they have answered many questions:
- A peptide that work in mice as well as minoxidil
- It also works in ex-vivo scalp human follicles (although here I am not sure I am convinced that hair length is the right measure)
- It is topically deliverable to human skin
Can this peptide be obtained? P5 GLYYF(662) ...I am pretty sure but not an expert on the topic.
Here is the full paper:
Here a corresponding patent:
U.S. Patent Application for COMPOSITION FOR PROMOTING HAIR GROWTH COMPRISING ADIPONECTIN-DERIVED PEPTIDE Patent Application (Application #20210196610 issued July 1, 2021) - Justia Patents Search
The present invention relates to a composition comprising adiponectin-derived peptide fragments and, more specifically, to a cosmetic composition and pharmaceutical composition for promoting hair growth comprising, as an active ingredient, one or more adiponectin-derived peptides selected from...
patents.justia.com
Interesting things about the paper: It is not only rats. They look at living human hair follicles (ex-vivo = outside the body). They also look at ex vivo human tissue to see whether it is transdermally deliverable and the answer is yes. They also do that on actual humans on the buttocks and they tell you the concentration (Each designated concentration of P5 (0.075, 0.75, 1.5, or 7.5 mM) was prepared in vehicle (30% ethanol and 70% polyethylene glycol, v/v). The vehicle and four concentrations of P5 were topically applied on the left buttock of human and occluded. After 24 h, we acquired full thickness skin tissue using a 6 mm punch for subsequent analysis.)
Clearly they do not say that these results portend a success in a clinical setting. But they have answered many questions:
- A peptide that work in mice as well as minoxidil
- It also works in ex-vivo scalp human follicles (although here I am not sure I am convinced that hair length is the right measure)
- It is topically deliverable to human skin
Can this peptide be obtained? P5 GLYYF(662) ...I am pretty sure but not an expert on the topic.
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