A Preliminary Study On Topical Cetirizine In The Therapeutic Management Of Androgenetic Alopecia. | HairLossTalk Forums

A Preliminary Study On Topical Cetirizine In The Therapeutic Management Of Androgenetic Alopecia.

Discussion in 'Hair Loss and Alopecia Published Studies' started by alscarmuzza, Feb 24, 2018.

  1. alscarmuzza

    alscarmuzza Established Member

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    Authors:
    Rossi A; a Department of Internal Medicine and Medical Specialties , 'Sapienza', University of Rome , Rome , Italy.
    Campo D; b Istituto Ortodermico Italiano , Rome , Italy.
    Fortuna MC; a Department of Internal Medicine and Medical Specialties , 'Sapienza', University of Rome , Rome , Italy.
    Garelli V; a Department of Internal Medicine and Medical Specialties , 'Sapienza', University of Rome , Rome , Italy.
    Pranteda G; a Department of Internal Medicine and Medical Specialties , 'Sapienza', University of Rome , Rome , Italy.
    De Vita G; c CNR-Nanotec, U.O.S. di Rende, Ponte P. Bucci, cubo 31C, 87036 Rende (CS) , Italy.
    Sorriso-Valvo L; c CNR-Nanotec, U.O.S. di Rende, Ponte P. Bucci, cubo 31C, 87036 Rende (CS) , Italy.
    Di Nunno D; a Department of Internal Medicine and Medical Specialties , 'Sapienza', University of Rome , Rome , Italy.
    Carlesimo M; a Department of Internal Medicine and Medical Specialties , 'Sapienza', University of Rome , Rome , Italy.
    Source:
    The Journal Of Dermatological Treatment [J Dermatolog Treat] 2018 Mar; Vol. 29 (2), pp. 149-151. Date of Electronic Publication: 2017 Jun 29.
    Publication Type:
    Journal Article
    Language:
    English
    Journal Info:
    Publisher: Informa Healthcare Country of Publication: England NLM ID: 8918133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-1753 (Electronic) Linking ISSN: 09546634 NLM ISO Abbreviation: J Dermatolog Treat Subsets: In Process
    Imprint Name(s):
    Publication: London : Informa Healthcare
    Original Publication: Houndmills, Basingstoke, Hampshire, UK : M. Dunitz and Macmillan Press, [c1989]-
    Abstract:
    Background: Androgenetic alopecia (Androgenetic Alopecia) is a common form of scalp hair loss that affects up to 50% of males between 18 and 40 years old. Several molecules are commonly used for the treatment of Androgenetic Alopecia, acting on different steps of its pathogenesis (Minoxidil, finasteride, Serenoa repens) and show some side effects. In literature, on the basis of hypertrichosis observed in patients treated with analogues of prostaglandin PGF2a, it was supposed that prostaglandins would have an important role in the hair growth: PGE and PGF2a play a positive role, while PGD2 a negative one.
    Objective: We carried out a pilot study to evaluate the efficacy of topical cetirizine versus placebo in patients with Androgenetic Alopecia.
    Patients and Methods: A sample of 85 patients was recruited, of which 67 were used to assess the effectiveness of the treatment with topical cetirizine, while 18 were control patients.
    Results: We found that the main effect of cetirizine was an increase in total hair density, terminal hair density and diameter variation from T0 to T1, while the vellus hair density shows an evident decrease. The use of a molecule as cetirizine, with no notable side effects, makes possible a good compliance by patients.
    Conclusion: Our results have shown that topical cetirizine 1% is responsible for a significant improvement of the initial framework of Androgenetic Alopecia.

    Latest Revision: 20180219
    Update Code:
    20180219
    DOI:
    10.1080/09546634.2017.1341610
     
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