A potential suppressor of TGF-beta delays catagen progression in hair follicles.

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A potential suppressor of TGF-beta delays catagen progression in hair follicles.

Tsuji Y, Denda S, Soma T, Raftery L, Momoi T, Hibino T.
Source

Shiseido Life Science Research Center, Yokohama, Japan.

Abstract

TGF-beta plays important roles in the induction of catagen during the hair cycle. We examined whether TGF-beta2 could activate a caspase in human hair follicles. Using active caspase-9 and -3 specific antibodies, we found that TGF-beta2 activated these caspases in two regions, the lower part of the hair bulb and the outer layer of the outer root sheath. In addition, we searched for a plant extract that can effectively suppress TGF-beta action. We found that an extract of Hydrangea macrophylla reduced synthesis of a TGDbeta-inducible protein. We confirmed that the extract has a potential to promote hair elongation in the organ culture system. Furthermore, it delayed in vivo progression of catagen in a mouse model. Our results suggest that the induction of catagen by TGF-beta is mediated via activation of caspases and that a suppressor of TGF-beta could be effective in preventing male pattern baldness.

 

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Okay so what practical way is there for us to suppress TGF-beta and is it safe to do so in an amount to stop male pattern baldness?

 

[oye_rg]

I have couple of large hydrangea growing in my backyard and am thinking of trying them to thicken my thinning diffuse hair. Do you guys thing I should:

1) chew on the leaves or
2) make a paste and apply topically or
3) infuse an oil with dried leaves

Generally, what works better? Topically or Orally for natural plant extracts, e.g. Saw Palmetto?

Thanks