A Novel Non-drug Sfrp1 Antagonist Inhibits Catagen Development In Human Hair Follicles Ex Vivo

[HairOnFire]

Kind of a strange abstract, but the lead researcher is excellent (Ralf Paus), and the medical journal it's published in is top-notch (British Journal of Dermatology). I wonder what the 'non-drug' antagonist is? A device or procedure of some kind?

https://pubmed.ncbi.nlm.nih.gov/32939777/

2020 Sep 16. Br J Dermatol

A novel non-drug SFRP1 antagonist inhibits catagen development in human hair follicles ex vivo

M Bertolini 1, J Chéret 1 2, D Pinto 3, N Hawkshaw 1 4, L Ponce 1, H Erdmann 5, F Jimenez 6, W Funk 7, R Paus 1 2 4
Abstract

Wnt signalling is one of the most fundamental molecular pathways for modulating the human hair cycle and is essential for maintaining hair growth1 . We recently identified that the Wnt antagonist, secreted frizzled related protein 1 (SFRP1), prematurely induces catagen in microdissected human scalp hair follicles (HFs) ex vivo1 . SFRP1 is inhibited by the potent hypertrichosis inducing immunosuppressant, cyclosporine A (CsA)2 , and the specific SFRP1 antagonist, WAY-316606, both of which prevent spontaneous catagen development1 .

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[polishkickbuttowski]

It's a compound called C1. https://sci-hub.tw/https://onlinelibrary.wiley.com/doi/10.1111/bjd.19552 Apparently side effect free but also not as effective as WAY.

 

[Armando Jose]

Kind of a strange abstract, but the lead researcher is excellent (Ralf Paus), and the medical journal it's published in is top-notch (British Journal of Dermatology)

They are also working with Way316606, see authors

 

[Dimitri001]

Man, this sounds pretty good. Seems safe, minimal systemic absorption expected and it activates wnt more than WAY. It sounds like something you might potentially be able to start taking right now. But I have two questions:

1) What exactly is this thing and where could you get it?

2) Since it activates wnt, should we be concerned about cancer here?

 

[pegasus2]

It looks like this is the product being released in Italy. It's less than half as effective as WAY-316606.

However, there is this:

The fact that C1 is not as beneficial as WAY -316606 in positively regulating human hair cycle ex vivo despite the higher stimulation of Wnt signalling may be related to the short ex vivo treatment, suboptimal concentration, or the importance of fine -tuning Wnt signalling during regeneration processes 7

Also, this is not a standalone treatment.

topical application therefore deserves to be clinically explored as an adjuvant cosmetic therapy for hair loss disorders associated with premature catagen development leading to telogen effluvium , such androgenetic alopecia