Ok it's settled, blüd flow causes ΑGΑ or even blüd flow causes Cardiogenetic Alopecia. So how do you propose you treat your CGA? Beta blockers? ACE inhibitors? ARBs? CCBs? KCOs? Loop-Diuretics? or you just gonna go all natural and do cardio-vascular training?
Yes it HAS been established that it is a vascular disorder and you can PLAIN AS DAY SEE what happens in the below example/patent.
Treatment of alopecia
Abstract
The invention provides a method for treating baldness by performing one or more surgical procedures that enhances vascular blood flow to the scalp. The surgical procedure may include a bypass operation to increase blood flow through a particular artery, preventing or reducing blood flow through an arterio-arterial or arterio-venous shunt respectively thereby redirecting blood flow, reducing a bony obstruction to blood flow, removing an obstruction in one or more arteries supply blood to the scalp, sympathectomy and use of a device to prevent vascular collapse, for example preventing collapse of an artery providing blood flow to the scalp.
The above descriptions of procedures are by no means comprehensive of the options available to a surgeon for enhancing the blood supply to the scalp. Any two or more of the above procedures may be used in combination where indicated. The inventor has surprisingly found that the improvement of blood supply to the scalp will result in improved hair growth or the return of hair growth. The invention may also prevent loss of hair growth thus preventing baldness or limiting an extent of baldness.
In one case, a patient who had been bald for some fifteen years displayed hair growth subsequent to surgery which improved the perfusion of his scalp. A surgeon may additionally or alternatively rely on endolumenal techniques for enhancing blood supply to the scalp. These techniques may include dilation techniques such as balloon angioplasty.
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Not all BP meds will grow hair and many cause hairloss in themselves independent of whatever it does to major arteries.
About the only things that really work to treat CGA that I know of that also grow hair are nitric oxide donors or hydralazine which captures superoxide radicals protecting it. It has already been established that NO reverses vascular stiffness thru elastase upregulation.
CCB's long acting ones like sustained release verapamil can reverse plaque buildup in the arteries. It is really the arteries fault and the capillaries just receive the blunt force of it. It works that way in end stage kidney disease too and Parkinson's where vasodilators(as a class) won't reverse calcium buildup in the brain.
Oral verapamil DOES reverse atherosclerosis and so does ORAL spironolactone.
Remember, the paradox where nothing much works topically but all the jaw dropping results come from oral administration. The IRONY is of almost 40 years of topical minoxidil we are going back to ORAL minoxidil. This is not just because of SULT 1A1 lacking either because those people were even growing a couple hairs from topical minoxidil but those same people say is they achieve way better results from oral.
Verapamil just happens to be a hypertrichosis causing agent so the distinction is blurred but there is a whole list of hypertrichotic agents when taken orally will do nothing to Androgenetic Alopecia. spironolactone is not a hypertrichotic agent so we must assign a different cause of hair growth to it.
More about verapamil:
pubmed.ncbi.nlm.nih.gov
academic.oup.com
