76th Annual Meeting Of The Society For Investigative Dermatology

[bekeero]

Some of the papers/abstracts that will be discussed are very interesting, including one based on this wounding related study co-authored by Dr. Luis Garza. Also interesting for our purposes is one in which Samumed’s Dr. Yusuf Yazici is a co-author. The title of this one is: “A small molecule modulator of the wnt pathway (SM04554) as a potential topical treatment for androgenetic alopecia (Androgenetic Alopecia)“.

Alcaris Therapeutics and their CEO Neal Walker are also present in a big way, both as sponsors and via leading a symposium on JAK inhibitors with many expert speakers. Hopefully someone asks them about their male pattern hair loss trials too since the symposium focuses on alopecia areate, scarring alopecia, pruritus and vitiligo. Dr. Christiano and Dr. Etienne Wang are also presenting a paper titled “Conditional ablation of JAK-STAT5 signaling induces anagen hair growth“

 

[Noisette]

Good find!

Thursday 27 April : Dr. Cotsarelis will present his study " Human hair follicle regeneration with trichogenic human dermal papilla precursor cells derived from induced pluripotent stem cells". There is also Professor Rox Anderson over there.

And Wednesday 28 April : Dr/ Cotsarelis for " Fat cells regenerate from myofibroblasts during wound healing."

" Immediately following this session, a 30 minute mixer will be held. Presenters, moderators and attendees will be able to interact as they enjoy light refreshments and snacks. These mixers are designed to encourage informal discussion, mingling and networking among SID meeting attendees"

source: http://c.ymcdn.com/sites/www.sidnet.org/resource/resmgr/docs/SID_Portland_Final_5_web.pdf

 

[Noisette]

http://www.jidonline.org/pb/assets/raw/Health Advance/journals/jid/JID-137-5S1.pdf

Abstracts :
1. Human hair follicle regeneration with trichogenic human dermal papilla precursor cells derived from induced pluripotent stem cells Kim1 , B Kang , Y Zheng , S Jo , K Kim , G Cotsarelis and O Kwon

" Dermal papilla precursor cells (DPPCs) in dermal condensates are unipotent cell population which can initiate hair follicle (HF) formation with epidermal placode cells. Intact human dermal papilla cells are known to regenerate de novo HFs with mouse epidermal cells. However, these cells cannot be utilized as human HF regenerative source due to the rapid loss of trichogenic properties upon culture. Here, we differentiated induced pluripotent stem cells (iPSCs) into trichogenic DPPCs via neural crest stem cells (NCSCs). Based on human embryonic HF formation process, we focused to mimic DPPCs at the hair placode stage which is the first recognizable status of HF formation. Interestingly, the syndecan-1 (SDC1) expression, normally expressed in human dermal condensates, was increased, whereas the CD133 expression, normally expressed in iPSCs and NCSCs, was dramatically decreased during the differentiation process. Generated SDC1+CD133- cell population showed higher trichogenic properties and HF regeneration efficiency. Human iPSC-derived DPPCs are capable of generating HF structure when combined with hiPSCs-derived epithelial stem cells in skin reconstitution assays. In conclusion, derivation of DPPCs capable of generating de novo human HF can be a novel treatment possibility for permanent alopecia patients".

2. Fat cells regenerate from myofibroblasts during wound healing
C Guerrero-Juarez , M Ito , Y Zheng , G Cotsarelis and M Plikus

" Regeneration via the lineage reprogramming of one cell lineage to another is believed to occur only in fish and amphibians, but it is not observed in mammals. We discovered in mouse that during wound healing adipocytes regenerate from myofibroblasts, a cell type thought to be differentiated and non-adipogenic. The transcription factors, Zfp423 and Pparg, normally expressed during adipocyte development, were reactivated and were required for adipogenic reprogramming of myofibroblasts. Myofibroblast reprogramming required the presence of neogenic hair follicles, which triggered Bone Morphogenic Protein (BMP) signaling and subsequent Zfp423 activation. Overexpression of the BMP antagonist, noggin, in hair follicles or deletion of the BMP receptor in myofibroblasts prevented adipocyte formation. Adipocytes formed from human keloid fibroblasts when treated with either BMP protein or placed in the presence of human hair follicles in vitro. We conclude that an adult mammal can utilize lineage reprogramming for regeneration and identify the myofibroblast as a plastic cell type that can may be manipulated potentially to treat scars in humans " .

 

[hairblues]

I need cliff notes.

 

[BTW]

man if people only knew how much of a joke these conferences have become, in the old days there was no internet so you did have to gather with people around the world to debate ideas, propose new ones. Now-days besides a nice trip at some lovely city the attendees get, nothing much comes out of it

 

[Abelibano]

Totally agree with BTW. If a true scientist wants to share his knowledge there is the internet for it. Nowadays he has all the technology for this- online databases and shared storage space,video calls etc.

Conferences are nothing more than fun for doctors who want to have a nice trip with all expenses covered (by who? ) and have a nice time with their wives / girlfriends / affairs

 

[bekeero]

It's a real talk in terms of nice trips to conferences, I've heard that for a long time but we have to be optimistic with many discoveries of baldness treatments, that's just a sense we're close to treatment in two years