5AR question

[Dice_Has_Hair]

It has been known that there are some baby boys and girls too, born without the 5 alpha reductase enzyme. Okay, well what type - type 1 or type 2? or both? Another question - I know this may sound kinda stupid but, is it still possible for these individuals to experience male pattern baldness even if the 5 alpha reductase enzyme is nonexistant? :?

 

[global]

No people without 5AR do not suffer from male pattern baldness.

 

[Dice_Has_Hair]

No people without 5AR do not suffer from male pattern baldness.

Yes, true but the thing is, is what if only one type of 5 alpha reductase is deficient while the other is normal - that would mean that there would still be circulating DHT in the blood and if the person was predisposed to male pattern baldness.............................they would suffer from it. Or another thing - if the person is deficient in both types of 5AR and still suffered from male pattern baldness, that means that Testosterone itself can indeed be enough to cause damage! Have there been any reports of such people born with this deficiency that still suffered from male pattern baldness? That would be interesting to know!

 

[Bryan]

The so-called "pseudohermaphrodites" in the Dominican Republic, New Guinea, and Turkey (and possibly certain other locations around the world) are born deficient in the 5a-reductase type 2 enzyme. They have normal levels of the type 1 enzyme. They do not experience androgenetic alopecia because it's the type 2 enzyme, not the type 1 enzyme, which is far more strongly associated with hairloss. Remaining levels of DHT from the type 1 enzyme that circulate in the bloodstream have a very insignificant endocrine effect on hair follicles.

Bryan

 

[Dice_Has_Hair]

The so-called "pseudohermaphrodites" in the Domican Republic, New Guinea, and Turkey (and possibly ceratin other locations around the world) are born deficient in the 5a-reductase type 2 enzyme. They have normal levels of the type 1 enzyme. They do not experience androgenetic alopecia because it's the type 2 enzyme, not the type 1 enzyme, which is far more strongly associated with hairloss. Remaining levels of DHT from the type 1 enzyme that circulate in the bloodstream have a very insignificant endocrine effect on hair follicles.

Bryan

So basically, even if these individuals have the male pattern baldness gene, they wouldn't lose hair since they lack the type 2 AR enzyme to create the DHT that is harmful to the hair follicles? Interesting 8)

 

[HairlossTalk]

Very...