1336 differentially expressed genes in alopecia

[Armando Jose]

Transcriptome profiling of pilosebaceous units in male androgenetic alopecia reveals altered junctional networks​

Comparative analysis of gene expression led to the identification of 1336 differentially expressed genes (PBH < 0.05), of which 366 displayed at least a 2-fold change between balding and control samples

Transcriptome Profiling of Pilosebaceous Units in Male Androgenetic Alopecia Reveals Altered Junctional Networks - PubMed

Transcriptome Profiling of Pilosebaceous Units in Male Androgenetic Alopecia Reveals Altered Junctional Networks

pubmed.ncbi.nlm.nih.gov

It is very complex, not only 5AR's

 

[Pls_NW-1]

We are fucked lol

There will never be a cure huh, genetical defects, we are, I guess...

 

[Armando Jose]

Cure is difficult if not impossible, but what about prevention?
Regarding sexes, it seem that women have a clue...

 

[pegasus2]

5-ar is just a preventative measure. It prevents these transcription changes from taking place, but can't reverse them.

 

[Pls_NW-1]

5-ar is just a preventative measure. It prevents these transcription changes from taking place, but can't reverse them.

Bridge once said that estrogens are there to reverse those. What's your opinion on that one!?

 

[Armando Jose]

5-ar is just a preventative measure. It prevents these transcription changes from taking place, but can't reverse them.

Do you think that finas is a preventive method? Messing with hormones to prevent?

 

[pegasus2]

Do you think that finas is a preventive method? Messing with hormones to prevent?

It's the safest way we have to prevent loss until Olix

Bridge once said that estrogens are there to reverse those. What's your opinion on that one!?

Yes. Estrogen upregulates and downregulates a ton of Androgenetic Alopecia genes.

 

[Armando Jose]

It's the safest way we have to prevent loss until Olix

https://www.olixpharma.com/eng/ OligoNucleic acid therapeutics?

 

[Pls_NW-1]

It's the safest way we have to prevent loss until Olix

Yes. Estrogen upregulates and downregulates a ton of Androgenetic Alopecia genes.

What's your thought on going on an E cycle for a period of time and then maintaining on AA's and 5ARi's?

Sorry for overrunning you.

 

[pegasus2]

What's your thought on going on an E cycle for a period of time and then maintaining on AA's and 5ARi's?

Sorry for overrunning you.

You'd have to cycle it long enough restore the hair completely so you're not going to avoid feminization. There's a thread on here where someone tried it. He got gyno, but not much hair growth.

OliX Pharmaceuticals Announces Results from Preclinical Study of Hair Loss Therapeutic Candidate

Company to discuss study results and present corporate overview at SMi’s 12th Annual RNA Therapeutics Virtual Conference on February 11 SUWON, Republic of...

www.globenewswire.com

 

[Pls_NW-1]

You'd have to cycle it long enough restore the hair completely so you're not going to avoid feminization. There's a thread on here where someone tried it. He got gyno, but not much hair growth.

OliX Pharmaceuticals Announces Results from Preclinical Study of Hair Loss Therapeutic Candidate

Company to discuss study results and present corporate overview at SMi’s 12th Annual RNA Therapeutics Virtual Conference on February 11 SUWON, Republic of...

www.globenewswire.com

But whats going on with the dudes de-feminize after ceasing E? It's most likely reversible, I think.
But I doubt we would be able to reverse feminization, if we will keep using AA's even without E... Any thoughts on this?

 

[pegasus2]

But whats going on with the dudes de-feminize after ceasing E? It's most likely reversible, I think.
But I doubt we would be able to reverse feminization, if we will keep using AA's even without E... Any thoughts on this?

De-feminization isn't so easy after you've been on HRT for years. You'd have to come off all AAs and take HCG to reverse it completely, and you might not be able to reverse it entirely.

 

[jan_miezda]

this is why hair cloning will be the only cure

 

[Pls_NW-1]

this is why hair cloning will be the only cure

Smh, maybe for my grandchildren heh

 

[FromHairy2LarryDavid]

Smh, maybe for my grandchildren heh

not even them if you stay on AA's long enough

 

[Pls_NW-1]

not even them if you stay on AA's long enough

Yeah, was just reffering to the fact that "hair-cloning" won't be something real we will get anytime. Doesn't matter if its me or my grandchildren, I will never have.

 

[Will Be an Egg in 5 years]

Jesus Christ, we're fucked.

Is there any study tha compare this to non balding men hormonal/genetic profile?

 

[Zon Ama]

AlphaFold 2 will save us (or at least our children)