.125 mg dutasteride vs. .05 mg avodart: a question of efficacy

[JJ Gittes]

My 3.5 year Propecia run seems to be running off the tracks, and so I may switch to dutasteride.

I see that Medical Wellness Center offers both avodart .5 mg, or dutasteride .125 mg.

They justify the alleged efficacy of .125 mg dutasteride by via what seems to be a rather dubious correlation between Proscar (5mg finasteride) and the efficacy of Propecia (1 mg finasteride).

As far as I know, Glaxo never conducted tests of dutasteride at .125 mg in either the Phase I or II trials.

Does anybody know whether .125 mg dutasteride has any claim to efficacy here?

 

[maddoc23]

Taking .125mg dutasteride would be equivalent to taking 1mg finasteride daily. To get the benefits of avodart (90%DHT inhibition) you need to take 0.5mg dutasteride daily.

D

 

[JJ Gittes]

makes sense but not proven

OK, thanks maddoc.

Now, while there's a certain logic in your assertion that .125 mg of dutasteride would equal roughly the DHT suppression gained by taking 1 mg finasteride, I don't believe that's been proven either way in tests. Or am I wrong?

 

[Bryan]

Re: makes sense but not proven

Now, while there's a certain logic in your assertion that .125 mg of dutasteride would equal roughly the DHT suppression gained by taking 1 mg finasteride, I don't believe that's been proven either way in tests.

Sure it has! Haven't you seen the actual data from Glaxo's dutasteride test? The doses they tested were 0.1 mg/day, 0.5 mg/day, and 2.5 mg/day. The 0.1 mg/day dose produced results (in terms of haircounts) that were virtually identical to the Proscar that was also included in the trial.

Bryan