10mg Oral Minoxidil and no results...

I

Isneezedsohard

Experienced Member
My Regimen
Reaction score
320
OtyMac said:
You could have nitrate tolerance and taking NAC would help that or anything that stops peroxynitrite from forming will make more "mileage" per molecule of nitric oxide by slowing its breakdown. NAC was reported in lamellar ichthyosis to grow hair at a 10% concentration but that wasn't really the purpose why it was used.

If it was me I would take LESS oral minoxidil(maybe 1 mg) and find things that stop superoxide from destroying nitric oxide

Hydralazine could be used topically too and has been mentioned as growing some hair on it's own.
pubmed.ncbi.nlm.nih.gov

Prevention of nitrate tolerance with concomitant administration of hydralazine - PubMed

Organic nitrates have frequently been used for the treatment of patients with congestive heart failure (CHF). Nitrate tolerance has been identified as a major limitation of this therapy preventing a continuous effect. In the past several years, an effort has been made to develop strategies to...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Search - United Pharmacies

www.unitedpharmacies.md www.unitedpharmacies.md

Verapamil does the same thing too as does cimetidine. I will post the studies on verapamil and cimetidine later as far as hair growth.

pubmed.ncbi.nlm.nih.gov

Verapamil Inhibits Mitochondria-Induced Reactive Oxygen Species and Dependent Apoptosis Pathways in Cerebral Transient Global Ischemia/Reperfusion - PubMed

The prefrontal cortex is the largest lobe of the brain and is consequently involved in stroke. There is no comprehensive practical pharmacological strategy for ameliorating prefrontal cortex injury induced by cerebral ischemia. Therefore, we studied the neuroprotective properties of verapamil...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov

Cimetidine: antioxidant and metal-binding properties - PubMed

Cimetidine is one of the most potent H(2) receptor antagonists for inhibiting excessive histamine-induced acid secretion and is currently used worldwide to treat peptic ulcers. In this study, levels of free radicals were assessed and the ability of cimetidine to act as an antioxidant was...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Melatonin does the same thing too by increasing mitochondrial SODase. Oral melatonin doesn't reach the skin in sufficient quantities to do anything either.
pubmed.ncbi.nlm.nih.gov

Melatonin and the electron transport chain - PubMed

Melatonin protects the electron transport chain (ETC) in multiple ways. It reduces levels of ·NO by downregulating inducible and inhibiting neuronal nitric oxide synthases (iNOS, nNOS), thereby preventing excessive levels of peroxynitrite. Both ·NO and peroxynitrite-derived free radicals, such...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

I also have a belief/wild assed guess that oral minoxidil and topical should provide different angles and grow more hair than either alone.
pubmed.ncbi.nlm.nih.gov

Treatment of permanent chemotherapy-induced alopecia with low dose oral minoxidil - PubMed

Chemotherapy-induced alopecia is a well-established cause of major distress to patients. Permanent chemotherapy-induced alopecia (PCIA) is the absence of or incomplete hair regrowth lasting longer than 6 months after the cessation of chemotherapy and it does not respond to standard treatments of...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
Click to expand...
So from this U r saying NAC helps make Oral Min work for some people?
 
O

OtyMac

Established Member
My Regimen
Reaction score
111
Isneezedsohard said:
So from this U r saying NAC helps make Oral Min work for some people?
Click to expand...
Yep...at least timed release does which I see Jarrows has it as unavailable probably because it is too effective and people were buying it to treat scamVid-19
pubmed.ncbi.nlm.nih.gov

Continuous oral N-acetylcysteine treatment and development of nitrate tolerance in patients with stable angina pectoris - PubMed

The presence of sulfhydryl (SH) groups appears to be fundamental to nitrate-induced vasodilation and N-acetylcysteine (NAC), a sulfhydryl (SH)-donor substance, potentiates hemodynamic responsiveness to nitrates. We investigated the effect of simultaneous administration of NAC and isosorbide...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Your best bet is to take NAC topically or find a sustained release NAC. If you find the sustained NAC PLEASE let us know.

I see the FDA who are bed partners with big pharma have plans to cut off the sales of NAC.

FDA changes in usage of NAC & it’s impact on Baseline+ – Protea Nutrition

proteanutrition.com proteanutrition.com
 
Last edited:
O

OtyMac

Established Member
My Regimen
Reaction score
111
Isneezedsohard said:
Then how the f*** do I purchase NAC?
Click to expand...

It looks like the law isn't in effect yet or retailers are ignoring it so get it while we can.


Here is some information about oral NAC:

"
Older studies reported NAC to have a plasma half-life of several hours, but with modern techniques the bioavailability
has been found to be poor and the actual half-life closer to 6 to 40 min.

After oral administration, Moldeus and Cotgreave wereable to detect only very small quantities of oxidized drug incirculation, with no free drug detectable (23).

Bioavailability was 5%, probably because of extensive first-pass hepatic metabolism. Numerous other investigators have confirmed the low bioavailability of oral NAC including slow-release preparations (25–28). After intravenous injection, Haradaet al.found that NAC was highly bound to plasma and tissue proteins,forming various disulfide compounds. Only small amounts of NAC were found in circulation despite the intravenous route of administration (29). It is clear from these reports that, after oral administration, NAC is almost completely metabolized before entering the systemic circulation. When considering the mechanism by which NAC can have a potential benefit in preventing CIN, its poor bioavailability must somehow be reconciled.The poor bioavailability of NAC after oral dosing is the result of extensive first-pass metabolism"
 
I

Isneezedsohard

Experienced Member
My Regimen
Reaction score
320
OtyMac said:
It looks like the law isn't in effect yet or retailers are ignoring it so get it while we can.


Here is some information about oral NAC:

"
Older studies reported NAC to have a plasma half-life of several hours, but with modern techniques the bioavailability
has been found to be poor and the actual half-life closer to 6 to 40 min.

After oral administration, Moldeus and Cotgreave wereable to detect only very small quantities of oxidized drug incirculation, with no free drug detectable (23).

Bioavailability was 5%, probably because of extensive first-pass hepatic metabolism. Numerous other investigators have confirmed the low bioavailability of oral NAC including slow-release preparations (25–28). After intravenous injection, Haradaet al.found that NAC was highly bound to plasma and tissue proteins,forming various disulfide compounds. Only small amounts of NAC were found in circulation despite the intravenous route of administration (29). It is clear from these reports that, after oral administration, NAC is almost completely metabolized before entering the systemic circulation. When considering the mechanism by which NAC can have a potential benefit in preventing CIN, its poor bioavailability must somehow be reconciled.The poor bioavailability of NAC after oral dosing is the result of extensive first-pass metabolism"
Click to expand...
Ordering NAC now
 
You must log in or register to reply here.
Community platform by XenForo® © 2010-2023 XenForo Ltd.
Top