0.5 Mg Avodart Eod Versus Everyday: Is Eod Worth It?
- Thread starter NSix
- Start date
According to a couple of docs on YouTube that would be about the same effectiveness. Remember the drug builds up in your system and has a long half life. It's very likely 0.5mg a day is not necessary as long as you're keeping it topped up in your system. I don't believe there is concrete data on this though.
- Reaction score
- 423
Taking dutasteride every day will be slightly more effective than EOD, but there isn't much difference. Taking it EOD will still be more effective than any dose of finasteride.
- Reaction score
- 8
0,5 eod is better for me
I was just reading about this yesterday. It sounds like 1mg EOD would be as effective as .5mg daily, but .5mg EOD would not because it's dose-dependent.
"A week after ceasing therapy, dutasteride patients still maintained their lower DHT level—a mean of 38.3 pg/mL—compared with the finasteride patients whose DHT levels climbed to a mean of 324.8 pg/mL a week after therapy ended. Overall, dutasteride maintained a 90.1% reduction for that week, compared with a 35.2% reduction for finasteride. Placebo patients experienced a negligible reduction in DHT."
"This study raised the question whether dutasteride could be taken less often than once daily. Dr. Marks responded that DHT suppression is dose-dependent. At 24 weeks, 0.01 mg/day of dutasteride produces less than a 10% reduction in DHT. At the same time point, a 0.1 mg/day dose causes about a 50% reduction in DHT. A weekly dose of dutasteride, 3.5 mg, produces a DHT of about 20 ng/mL, which is close to the level caused by a 0.5-mg daily dose."
https://www.urologytimes.com/clinical-pharmacology/dht-rebound-minimal-after-missed-5-ari-doses
"A week after ceasing therapy, dutasteride patients still maintained their lower DHT level—a mean of 38.3 pg/mL—compared with the finasteride patients whose DHT levels climbed to a mean of 324.8 pg/mL a week after therapy ended. Overall, dutasteride maintained a 90.1% reduction for that week, compared with a 35.2% reduction for finasteride. Placebo patients experienced a negligible reduction in DHT."
"This study raised the question whether dutasteride could be taken less often than once daily. Dr. Marks responded that DHT suppression is dose-dependent. At 24 weeks, 0.01 mg/day of dutasteride produces less than a 10% reduction in DHT. At the same time point, a 0.1 mg/day dose causes about a 50% reduction in DHT. A weekly dose of dutasteride, 3.5 mg, produces a DHT of about 20 ng/mL, which is close to the level caused by a 0.5-mg daily dose."
https://www.urologytimes.com/clinical-pharmacology/dht-rebound-minimal-after-missed-5-ari-doses
- Reaction score
- 423
Yes that is correct. There is essentially no difference between taking 1mg EOD and taking 0.5mg a day. But taking 0.5mg EOD will be less effective.