I know it's a study with mice but an interesting set of parameters for microneedling. Most optimal result at 30 micro-wounds per cm2 at 2 mm depth, 2 x per week for 3 weeks, needles heated to 500 degrees C.
Human skin is thicker than mouse skin so depth to reach dermis would be greater, I think.
Customer-made micro-injury instrument
To standardize the micro-injury, we designed and made a fine instrument to control the depth, density and temperuture of the injury (Fig. S1A). The density was achieved by a disposable multi-needle head (Fig. S1B), in the present study we set at 0, 10, 20...
This suggests that his punch size is even smaller than the standard 0.8mm. I would be interested in knowing the smallest punch size he has successfully used.
I think it's possible that Dr. Zarev just has a good eye, a steady hand and decent stamina. Those three things combined could account for much of his current reputation. He can extract high numbers without the extractions 'bumping' into one another. That ability is not a consistent feature...
One innovation in FUE may be the use of AI to optimize the largest number of donor extractions possible without leaving a visibly depleted area. AI could assist the surgeon to select the FU's in the most optimal pattern possible.
That was Dr. Wesley, in NYC. He was attempting to refine FUE by a method called piloscopy, which uses an extractor underneath the skin of the scalp to remove the follicle from below, thereby avoiding the punctuate scarring that is the result of standard FUE. I know that he spent time developing...
What do you think is the smallest punch size possible that will remove the minimal amount of surrounding tissue of the FU needed for survival? What is the current smallest punch size used by a hair transplant surgeon in anybody's experience?
Also, I remember reading that bisections of an FU leads to both a thinner outcome and, for some of those units, a finite cycle (ie, the hair cycles a few times and then stops growing altogether).
From that patent, it seems that the initial perturbation is significant enough to create a scab. This is not some light needling with an application of minoxidil to get things rolling. Looks like a deep wounding, covered by a hydrogel and after some days, the application of a hair...
"Thus, treatment with one or more hair growth-promoting agents in combination with integumental perturbation provides a window during which a third treatment that alters the follicle development program may be administered in order to significantly change the number or quality of follicles in a...
In theory, yes. You are creating more wounds in a defined area the more times you pass over the same area with a roller/pen. I still think that the best response seen at the earliest time possible will be around the border areas between the thinning portions of the scalp and the more robust...
Certainly, it seems, diffuse thinners respond better to wounding than those treating larger bald areas. And the Dhurat study showed pictures of good responders who were already blessed with some measure of volume in the treated areas. It would seem that the thinning areas bordering with terminal...
Well, I'm hoping that the science behind quorum sensing is all that stands between me and the success of wounding. I'm skeptical, though, and don't see how density might be the difference maker. I've also been convincing myself that there is a tipping point when it comes to the positive impact...