Recent content by Sweuser

Yes I saw that too. Have been using topical GABA for two days now. Felt it was time trying something new.

A Wnt5a-Cdc42 axis controls aging and rejuvenation of hair-follicle stem cells Abstract Normal hair growth occurs in cycles, comprising growth (anagen), cessation (catagen) and rest (telogen). Upon aging, the initiation of anagen is significantly delayed, which results in impaired hair...

Very interesting! You probably saw the newly published paper on FGFRi and dermatological side effects associated. https://theoncologist.onlinelibrary.wiley.com/doi/10.1002/onco.13552 They also proposed an absolute contraindication for continuing treatment. Good luck!:)

Thanks! I realized now you posted two articles and I think I follow you... Do we know if FGF9 still have positive effect on HFs if Infigratinib is present? Is the positive effect only via Smoothened?

Hi pegasus, Interesting read, as always! I'm not sure if you have seen this, but with what you're trying to accomplish parallell, this might interfere? FGF signaling is required for wnt driven ectopic HF initiation and involved in wound-induced hair neogenesis. "Gene expression analysis of...

Clinical Study to Evaluate the Efficacy and Safety of a Hair Serum Product in Healthy Adult Male and Female Volunteers with Hair Fall Abstract Background: Hair fall is a widespread problem among all genders, ages, and ethnicity with both physical and psychological effects. Objective: This...

Preferably an Alpha1 stimulator, but yes, a lot of them have overlapping effects. Alpha-r agonists are sold already as eye drops, ex Phenylephrine with maximum effect within 30-60 minutes and fully eliminated after 6 hours(applied in eyes). It would be interesting to know more of what mimics...

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss Abstract Persistent hair loss is a major cause of psychological distress and compromised quality of life in millions of people worldwide. Remarkable progress has been made in understanding the molecular basis of hair loss...

Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? Abstract Topical hormone therapy with natural or synthetic ligands of nuclear hormone receptors such as glucocorticoids, vitamin D analogues and retinoids has a long and highly successful...

He explanes this with VDR to AR ratio. His theory should be easy to confirm with the use of calcipotriole. But he has not been active with updates?

I've been wanting to try topical glyceryl trinitrate for a long time. Maybe this can show if It's something to chase.

I guess it's possible to increase absorption of topicals when used go create microdermabrasion. Deeper layer i'm not sure of the benefets for Androgenetic Alopecia. "Among topical immunotherapeutic agents, 88% phenol peel is a contact irritant8 that induces epidermal coagulation "therapeutic wounding" and can...

I've seen it for areata, not Androgenetic Alopecia. What's the theory? Induction of collagen production??

Yes, It is. It might be favorable with a higher concertration though. A few different brands was discussed here: https://www.hairlosstalk.com/interact/threads/anyone-seen-this-study-outperforming-minoxidil.125166/

Migration Inhibitory Factor in Conditioned Medium From Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth Abstract Conventional therapeutic applications of mesenchymal stromal cells (MSCs) focus on cell replacement and differentiation; however, increasing...