Recent content by sapinho

Exactly. This has also been my theory. DHT->NF-KB over-expression->COX2 over-expression->increased PGD2 (i.e., body's response to chronic inflammation, but not good for hair) I wondered why my hairloss first went nuts when exposed to a high-humidity environment with mold, turns out, mold...

TN, aged garlic, curcumin, resveratol, and vitamin C, all have something to do with interfering with the activity of the transcription factor NF-kappB, relating to induction of COX-2 expression (correct me if I'm wrong), and I've seen, at least in the case of curcumin, that it can help prevent...

If you're serious enough for a transplant, then go ahead and try finasteride for at least a year. You'd probably have to stay on finasteride after the surgery anyway. I'm not saying you *should*, just logical advice in the *case* that you're honestly thinking about a transplant.

Sounds like you're okay with it. Why worry now? Most people on this forum are accustomed to aggressive male pattern baldness. Given that you're 40 and this is all it has come to, I don't think an aggressive regimen is in order. Also, given that it's been like this for years, minoxidil probably won't do much at...

Re: A recently discovered new factor in AA, the cure is near :) He's only talking about blocking COX2, which basically means he's blocking a major pathway to inflammation. You'll still get PGE2 from normal COX1 levels. Yes, many things online talk about rising PGE2 levels due to rising COX2...

Re: A recently discovered new factor in AA, the cure is near :) I had no idea what a Niacin (Vit. B-3) flush was, never experienced it, but it appears to be somewhat of a health fad. The capillaries are dilated and gives a warm, sometimes burning(!)/itchy, feeling throughout the skin. Whether...

Re: A recently discovered new factor in AA, the cure is near :) I agree that that's a decent approach, sorry to sound like a pessimist. Just easier to get behind what the study did prove. It certainly would have been interesting if the study, which noted the overexpressed immune response...

Re: A recently discovered new factor in AA, the cure is near :) COX2 should increase PGE2. Right? Doesn't this strike you as a mystery as to "how" DHT leads to increased COX2 while not increasing PGE2? I'm going to assume that the culprit is more than just (DHT-induced) COX2 leading to...

Re: A recently discovered new factor in AA, the cure is near :) The general impression is this: DHT => Elevated COX-2 => Elevated PGD2 => Let's block COX-2 or PGD2 Where, -- Blocking COX-2 => Lower PGE2 (bad) -- Blocking PGD2 has unknown additional consequences (maybe "some" is necessary)...

Re: A recently discovered new factor in AA, the cure is near :) People have tried all sorts of anti-inflammatories over the years, surely some of them inhibiting PGE2, but I don't remember anyone suddenly losing their minoxidil-dependent hairs. If this observation is correct, this would mean that...

I had never seen VEGF discussed before. Looks interesting. Though doing a google search across this site shows it's nothing new, el_duterino has tried it, along with some random posts pointing out that Grape Seed and Curcumin inhibit it, despite the fact that both of these are thought to...

Since finasteride blocks DHT at such low concentrations, orders of magnitude better than 'natural' alternatives, isn't there a chance your hair follicles can derive a greater benefit from applying it topically? ...obviously it's not absorbed instantaneously, a guy who knows nothing like me would assume...

All pictures were taken shortly after showering and drying hair. Depends how well I dried my hair I guess. I had used Keto and minoxidil for more than 10 months nonstop prior, and prior to that, minoxidil continuously for 2 years (there was a 5 month break in between). Given that I've used minoxidil for...

Update with pictures. RECAP: --Mangiferin, reported 5AR inhibitor (2010 Chinese study), at 400 mu-g/mL has the nearly the same inhibitory effect as Finasterside at 50 nM. 50 nM being the ~IC value of finasteride for the in-vitro model used. --Mango bark extract "Vimang" (Cuban product containing 7%...

Per the article you'd have to scalp yourself and apply the hydrogel as a regenerative skin-matrix. Good luck with that. Joking aside, I suppose someone could make a machine that automated drilling out a dead follicle with a laser, filling it with Amatokin-impregnated hydrogel, and temporarily...