Recent content by S Foote.

I contacted one of the authors of that study for more information some time ago. There were two big differences in this study to the normal transplantation procedure in Humans. First the balding Human samples had all the tissue removed from them. There was no fibrotic tissue attached to them...

I refer to the fluid pressure in the surrounding dermal tissue Armando. Sebum is released within the follicle, if anything increased sebum pressure will inflate hair follicles not miniaturize them.

If you consider the structural characteristics of hair follicles, this kind of "shock" hair loss is quite easy to explain and identifies the common factor here. Any tissue trauma causes tissue swelling. This increase in tissue fluid pressure causes a distortion of the local hair follicles...

With respect Armando, how can this possibly cause miniaturisation of the hair follicle itself?

Just a few points about that immune deficient mice study. These mice do not produce fibrotic scar tissue upon healing, because of their immune status. Also I corresponded with one of the authors of that study when it first came out, and he confirmed that all the transplanted follicles were...

That's true, the question is how does the hair cycle adjust hair growth? We should remember that the original function of hair was as an insulator. This needed adjustability, and in my opinion the hair cycle evolved to achieve this adjustability. During anagen enlargement, the growing follicle...

Leaving the question of any significant direct influence of DHT on hair follicles to one side, the fact is that all normal tissue growth can be prevented by a certain degree of external resistance. No "normal" hair follicle growth is immune to this, DHT resistant or not. Only cancer cells can...

There is a major influence upon hair follicle enlargement that is being overlooked in the current research, and explains why some effective treatments like this can grow a lot more hair, but also risk cancer development. All normal cell growth and tissue development is subject to the external...

There is some correlation with the area of scalp hair loss, and the area of beard growth. https://link.springer.com/article/10.1007%2FBF00636601 Quote, " In 100 clean-shaven men direct measurement of the area of glabrous skin on the forehead and calvaria was found to be proportional to that of...

I would just like to make a point here, but I don't intend to get into anymore unconstructive debates on these forums. There is a very important scientific rule, that any valid theory must satisfy. This is a good description quote. "Parsimony: When there are multiple explanations of a...

The thing is Armando, any valid scientific theory has to explain the mechanism of change using the rule of parsimony. (Ockham's razor). How does your theory explain the reduced growth of all the cell types in balding follicles, and the reverse effect in body follicles? How does it explain the...

I mean the tissue around the follicles is slightly swollen. This is the only mechanism that explains follicle miniaturisation and all the other changes in the bald scalp, by one initial action. This is what any valid scientific theory has to do.

In my opinion Armando any theory about changes in hair growth, must have some link to purpose in evolution. The original purpose of hair was for temperature control of the body. Can you describe any link with this action of sebum upon hair growth, and temperature control? There is an important...

The scalp is tight in male pattern baldness. The only thing that makes sense of this is DHT induced lymphedema, because this increased fluid pressure also explains all the other observations. The immunology and changes in the various mast cell secreted prostaglandins, the hypoxia, and the increased sweating...

I presume you used the topical Finasteride on your balding scalp? That is not my suggestion if you read my post again. What you should be doing with such topicals, is using them on the hairy parts of the scalp and the beard area, according to this indicated action of DHT.