Recent content by persistentone

What chemical additives make a chemical transdermal versus dermal? Is there anything you could add to a transdermal cream to make it more dermal?

Fantastic science-based summary of how estriol stimulates the estrogen B receptor and helps to keep hair in the anagen phase longer.... What is your current status with estriol? Is there any guideline on how a man would avoid unintended side-effects with estriol? Can any of the estrogen...

The cream would be a pain to apply over a broad area, and it would make your hair look like a mess. I think a shampoo would give broader coverage quickly and could be engineered to not make the hair look filled with a dry cream. Do you have a link to any of the studies that talk about...

What is the recommended dose and where are the studies to verify that dose?

I have not seen many studies giving estradiol to men and evaluating effects on hair loss over the course of years. You read the occasional N=1 report about a male-to-female transitioning, but I have not seen reports where men who are not transitioning are given low doses of topical estrogens in...

Did you try RU58841 with the K&B solution? My hypothesis about the people with the heart side effects is they might be taking it in a form that easily comes off on their pillows. It gets into the mouth, so the amount of systemic absorption might be much higher.

According to this source, the half-life for one of the metabolites derived from RU58841 is 20 hours: http://www.ru58841.net/ru58841-side-effects/ So you would think that by 100 hours you would clear about 97% of that metabolite if the clearance is being dictated by half-life only. How long did...

I just wonder how many people make valid distinctions between erectile function and libido. Many might mistakenly call erectile function a libido problem, which it is not. Your test with Adex seems valid and that is interesting evidence. An alternate hypothesis to explain that might be that...

Do you have any studies showing that? The only studies I have found say high estrogen will lower erection quality, not libido.

The studies I have seen are pretty clear on the sexual role of estrogen in men: * Estrogen in the penis will cause erectile dysfunction. There is no real replacement for DHT as an erectile function stimulant, followed by testosterone. * Estrogen in the brain will increase libido So this is...

Do you have any studies that directly compared 17b estradiol to estriol for male androgenic alopecia?

This looks like a really bad photoshop job. Notice the hair in the regrowth area is a different shade, a different level of focus than the rest of the photo, and completely different hair texture, straightness, and style.

How can you possibly know this with such certainty when they have not even published the studies and there are so few studies on CB?

Have you tested both your DHT and testosterone levels? What is your total testosterone to DHT ratio? My guess is it will be high.

What is the full chemical name for CB? I guess it might be a good idea to at least wait for the Phase 2 study for CB "Beezula" to complete?