Recent content by jondoeuk

Big three?

Pyrilutamide is a topical nonsteroidal antiandrogen developed by Suzhou Kintor Pharma, a subsidiary of Kintor Pharma Limited. In addition to its ongoing clinical development, it has been introduced to the market as a cosmetic under the brand name Koshine...

That's the grey market for you! Cosmo Pharma should release the six month phase three results this quarter, and twelve month results in the first half of 2026. If all goes to plan they expect to receive FDA approval in late 2027 and will release it soon after. The market research that was done...

Pyrilutamide is sold (by Kintor Pharma) under the brand name Koshine https://www.koshinemall.com?sca_ref=7290283.HUfjZVF7fCV5W

Keep us updated. For pyrilutamide, patents. As for fluridil, a search on certain sites for topilutamide. I will look for the binding affinity of topical spironolactone when I get time. I currently take oral finasteride, but plan to add (topical) liposomal dutasteride.

Long-term (52-week trial) data. The results demonstrated excellent safety and efficacy. Key highlights: 46% of patients saw a ≥10 hairs/cm2 change in total area hair count (TAHC) from baseline. 20% of patients saw a ≥20 hairs/cm2 change in TAHC. This trial involved a total of 16 clinical...

Hair growth oil?

So? The plural of anecdote is anecdotes, not data.

A clinical observational trial found that pyrilutamide plus minoxidil was superior. From it: ''After 24 weeks of treatment, the TAHC of the Combination Drugs Group showed an increase of 30.54 hairs/cm2 from baseline, which was 10.29 hairs/cm2 more than the Minoxidil Group, with statistically...

Topical finasteride has at least one strong RCT showing it works almost as well as oral. Other data has been published as well. Broadly, it shows that topical finasteride led to reduced hair loss, increased total, and terminal hair counts...

There is a lot of misinformation surrounding finasteride, especially when it comes to cognitive impairment, anxiety, depression, and even suicidal thoughts. Not only is there no data showing any of these from any of the randomised and placebo controlled trials that have been conducted, all lack...

Different batches? Who did you buy it from?

On average, only 2.1-3.8% had side effects from oral finasteride https://pubmed.ncbi.nlm.nih.gov/23130269/ So I wouldn't worry. If you do get sides, you can either push through, limit how often you take it, reduce your dose, or switch to topical finasteride.

Pyrilutamide is another nonsteroidal antiandrogen. It binds to the androgen receptor with a very high affinity (IC50* of 0.28 nM). The IC50 ranges from 10 nM to 85 nM for Fluridil. The IC50 of RU58841 is 100 nM. A lower IC50 (the concentration of a molecule that is needed to inhibit a...

For hair loss, but latanoprost and bimatoprost have been approved since the 1990s and are used to lower intraocular pressure in (open-angle) glaucoma and ocular hypertension. Data https://pubmed.ncbi.nlm.nih.gov/21875758/ https://pubmed.ncbi.nlm.nih.gov/28521549/...