Recent content by hedgehog_info

Yes I believe the 14 day tox study had side effects. The program will revert back to curis to develop if they want to reformulate the topical application. Wouldn't expect them to do this anytime soon.

Well honestly HM is probably easier to get past the FDA. Most of the process occurs in vitro. Maybe when I am rich I can afford to do some experiments. Until then....

What are the results? The article is from 1998????

How Curcumin Helps Fight Cancer Main Category: Biology / Biochemistry News Article Date: 31 May 2007 - 10:00 PDT * Cancer / Oncology Scientists showed that curcumin, the main ingredient of the Indian herb turmeric, restores key immune cells that fight off cancer. The immune system...

Let me try to explain how this (wound healing) works with regards to hair growth and cancer. In embryonic development a lot of pathways get turned on to generate certain cell types such as heart, neuronal, muscle, skeletal...ect. The Wnt's, BMP's, Notch, Hh's, FGF's, TGF, are a few of the...

http://www.hhmi.org/news/moon20070518.html May 18, 2007 Kidney Cancer Shuts Down Protein Destruction Complex New evidence shows that Wilms tumor - a rare kidney cancer that affects children - promotes its own growth agenda by taking over a genetic program used by normal cells during...

Yes that is the main problem with most of these embryonic pathways. In embryonic development different concentrations of certain proteins will give rise to different types of cells and tissues. For example, high concentrations Hh a gives rise to neuronal tissue, in creation of hair follicles...

Yes Wnt and Notch pathways specify location and number of hair follicles. Like the Hedgehog pathway chance for tox issues. Same type of embryonic pathway activation.

Just thought I would through in a pic in the study Fig. 1. (a) Photograph of dorsal skin of C3H mice at 15 days after treatment. At 15 days after a single application of CsA (1%) or vehicle (ethanol), hair in the applied region was clipped and photographs were taken, (b) anagen induction...

Involvement of sonic hedgehog in cyclosporine A induced initiation of hair growth J Dermatol Sci. 2007 Apr 26; [Epub ahead of print] Cyclosporin A (CsA) is an immunosuppressant which can induce hypertrichosis as a side effect and attempts have been made to treat alopecia [1]. Studies...

Yes the cancer research is the most interesting... Already in the clinic :)

"The identification of functional non-coding variants surrounding AR may have significance not only for baldness, but also for the many other complex conditions that have thus far been linked to AR." In English it means... Parts of the DNA that are not part of the protein are probably...

Hair Follicle Regeneration Using Grafted Rodent and Human Cells. J Invest Dermatol. 2007 Apr 12; [Epub ahead of print]Click here to read Links Hair Follicle Regeneration Using Grafted Rodent and Human Cells. * Ehama R, * Ishimatsu-Tsuji Y, * Iriyama S...

A little snippet from the Journal Nature. Once again this is about using developmental biology tools in the adult. If you don't have access to this article and would like it plz PM me. Molecular Mechanisms Regulating Hair Follicle Development Sarah E Millar Departments of...

Hi Doctor, From what i understand the hair follicle is one of the few cells that continually express sonic hedgehog through out life. In most other places in the body it is only turned on when your tissue needs to repaired. There have been a few studies that used a mouse model of hair loss...