Recent content by acbrantlin

I still don't understand why people afraid of finasteride wouldn't be equally or more afraid of HMI-115. You can apply nearly the same logic to both.

I just need to know what spark in your brain convinced you to declare it a cure for young people after reading pages and pages of people in this thread reiterating that we know virtually nothing about the mechanism or efficacy of HMI-115 in humans and that there is still a significant likelihood...

What point are you making with that quote? Because it only aligns with what I said. Are you confused by the term "prolactin receptor blockade"? Because that does not at all mean it inhibits prolactin production. HMI-115 is an antibody that binds to prolactin receptors. Prolactin also binds to...

HMI-115 doesn't block the production of prolactin. My understanding is that it binds to prolactin receptors (PRLR) and alters its shape to where prolactin can still bind to it but the resulting signal transmission is disrupted. The effects are presumably drastically different than inhibiting...

Since this trial was too small with no placebo, it's not reliable at all. But largescale 1mg propecia trial was around a 13 to 16 mean increase per square cm at the vertex compared to baseline after 6 and 12 months, and only a 7 to 10 increase in front/mid at 6 and 12 months. And placebo was a...

The assumption is that the dosage they used in the phase I trial completely blocked PRLR signaling, which is the goal of the drug. I don't know if that's true, but if it is then a higher dose would have zero additional effect and it would explain why they're only testing lower doses to see if...

My man, nobody knows. Nobody will know until long after it's out, if it ever comes out. And even then nobody will know for sure. The same answer for every new hair loss treatment. And it will be the same answer for whatever the next new potential treatment is. The only thing we can do is post...

I get it. This has been your domain for a very long time and you're free to baselessly call people gaslighters and emotional and it's all kosher, but if anyone returns fire they're breaking the cardinal rule of debate and you automatically win the argument. You can write paragraphs and it's...

I understand you need to reconcile the fact that the years and years of time you've spent researching hair loss has amounted to no more utility or understanding than what the average person can surmise from a few hours googling studies. I'm sure that's a tough pill to swallow and human ego...

What conclusion was I jumping to? The only possible conclusion one could interpret from what I said is that nobody knows anything. Not me, not you, not the developers of the drug. Even if it works, nobody will know why for many years if ever. It's simply not possible and we can only guess...

I think it is a bit presumptuous to claim inflammation has no additive effect on the dermal papilla's ability to induce hair growth. It may not be causative of Androgenetic Alopecia, but it is more than reasonable to believe the resulting introduction of inflammation to that environment assists at least with the...

Right, but JAK inhibitors don't work on most areata sufferers, which would suggest any success from JAK inhibition isn't a result of it stopping the immune system from attacking the follicle, and is probably just a result of it reducing the rate at which inflammatory cells created for those...

I am also curious how it could affect retrograde alopecia particularly because retrograde is common even among full density norwood 1-2s and often nonexistent in completely bald norwood 7s, which suggests there are additional factors besides traditional male pattern genetic loss. The very...

He said 8 days ago: -"I used topik on a bald patch they shaved to count the hairs near the vertex. Nowhere else." So yeah his photos and words definitely don't add up. I understand the large impact of sunlight on the appearance of thinning hair, but it still just doesn't make sense. Because...

Just a reminder to everyone that the doses they're experimenting with in the phase 2 trials are less than the dose he received, which is contrary to his logic in that comment. But also his claim that he only used toppik on the 2cm patch they shaved is... hard to believe based on all the...