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cool new potential approach to treating Androgenetic Alopecia that hasnt been discussed here much
www.frontiersin.org
"We found that Zyxin is upregulated in the affected frontal HFs of Androgenetic Alopecia patients compared to the unaffected occipital HFs. To further study the effect of ZYX on HF and Androgenetic Alopecia, we conducted in vivo and in vitro studies using mice, cultured HFs, and dermal papilla cells. Using in vivo experiments, ex vivo cultured HFs and in vitro DPCs, we found that reduced ZYX expression enhances hair shaft production, delays HF catagen entry, and enhances DPC proliferation and inductivity. Higher activity of DPCs delays the process of hair miniaturization and promotes shaft elongation. Hair shaft elongation is apparently negatively correlated to hair miniaturization. All of the above results show that ZYX plays an essential role in Androgenetic Alopecia, and ZYX inhibition might be an effective means for the treatment of Androgenetic Alopecia and the other hair loss diseases."
most papers also show that prolactin activates transcription of ZYX
how can ZYX expression be reduced?
Increased Expression of Zyxin and Its Potential Function in Androgenetic Alopecia
Androgenetic alopecia (Androgenetic Alopecia) is the most common progressive form of hair loss, occurring in more than half of men aged > 50 years. Hair follicle (HF) miniaturization is a feature of Androgenetic Alopecia, and dermal papillae (DP) play key roles in hair growth and regeneration by regulating follicular cell...
"We found that Zyxin is upregulated in the affected frontal HFs of Androgenetic Alopecia patients compared to the unaffected occipital HFs. To further study the effect of ZYX on HF and Androgenetic Alopecia, we conducted in vivo and in vitro studies using mice, cultured HFs, and dermal papilla cells. Using in vivo experiments, ex vivo cultured HFs and in vitro DPCs, we found that reduced ZYX expression enhances hair shaft production, delays HF catagen entry, and enhances DPC proliferation and inductivity. Higher activity of DPCs delays the process of hair miniaturization and promotes shaft elongation. Hair shaft elongation is apparently negatively correlated to hair miniaturization. All of the above results show that ZYX plays an essential role in Androgenetic Alopecia, and ZYX inhibition might be an effective means for the treatment of Androgenetic Alopecia and the other hair loss diseases."
most papers also show that prolactin activates transcription of ZYX
how can ZYX expression be reduced?
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